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Abcc4 Gene Detail
Summary
  • Symbol
    Abcc4
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 4
  • Synonyms
    D630049P08Rik, MOAT-B, MRP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443111
    NCBI Gene: 239273
Location & Maps
more
  • Sequence Map
    Chr14:118482692-118706219 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      223528 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ABCC4, ATP binding cassette subfamily C member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ABCC4, ATP binding cassette subfamily C member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MOATB, MOAT-B, MRP4
  • Links
    NCBI Gene ID: 10257
    neXtProt AC: NX_O15439

  • Chr Location
    13q32; chr13:95019829-95301446 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    148
  • Chemically induced (other)
    1
  • Gene trapped
    144
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Abcc4
  • Incidental Mutations
Homozygous null mice are viable and fertile. Homozygotes for one null allele display impaired organic anion transport in the blood-brain and blood-cerebrospinal fluid barriers and kidney. Homozygotes for a second null allele display hypoalgesia and abnormal PGE2 physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032849 Ensembl Gene Model | MGI Sequence Detail 223528 C57BL/6J ±  kb
transcript ENSMUST00000036554 Ensembl | MGI Sequence Detail 5729 Not Applicable  
polypeptide ENSMUSP00000042186 Ensembl | MGI Sequence Detail 1325 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1907 from dbSNP Build 137
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR017871 ABC transporter, conserved site
    IPR003439 ABC transporter-like
    IPR011527 ABC transporter type 1, transmembrane domain
    IPR030240 Multidrug resistance-associated protein 4
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:222957 Vasilyeva A, et al., Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b. Cancer Res. 2015 Jul 1;75(13):2729-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory