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Abcc4
Gene Detail
 Symbol
Name
ID
Abcc4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
MGI:2443111
Synonyms D630049P08Rik, MOAT-B, MRP4
Feature Type protein coding gene
Genetic Map
Chromosome 14
62.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:118482692-118706219 bp, - strand
From NCBI annotation of GRCm38

  223528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74563  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Abcc4

Human
homologs
Human Homolog ABCC4, ATP-binding cassette, sub-family C (CFTR/MRP), member 4
NCBI Gene ID 10257
neXtProt AC  NX_O15439
Human Synonyms  EST170205, MOATB, MOAT-B, MRP4
Human Chr (Location)  13q32; chr13:95019829-95301441 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(170) : Gene trapped(168) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile. Homozygotes for one null allele display impaired organic anion transport in the blood-brain and blood-cerebrospinal fluid barriers and kidney. Homozygotes for a second null allele display hypoalgesia and abnormal PGE2 physiology.
 
Interactions
Abcc4 interacts with 290 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process drug transmembrane transport, positive regulation of smooth muscle cell proliferation
Component basolateral plasma membrane, membrane, ...
Function ATP binding, drug transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (143)    Tissues (143)    Images (17)
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 143
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000032849 (Evidence)
Entrez Gene239273 (Evidence)
DFCITC1581456
DoTSDT.101272532, DT.102556804
NIA Mouse Gene IndexU035923
Consensus CDS ProjectCCDS27335.1, CCDS49565.1
International Mouse Knockout Project StatusAbcc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 239273 NCBI Gene Model | MGI Sequence Detail 223528 C57BL/6J ±  kb
transcript NM_001033336 RefSeq | MGI Sequence Detail 5729 C57BL/6 
polypeptide NP_001028508 RefSeq | MGI Sequence Detail 1325 C57BL/6 

For the selected sequences
All sequences(30) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(1907 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1911)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003560 multidrug resistance-associated protein 4
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:202517 Dankers AC, et al., Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP). Biochim Biophys Acta. 2013 Oct;1832(10):1715-22
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory