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Mpzl3 Gene Detail
Summary
  • Symbol
    Mpzl3
  • Name
    myelin protein zero-like 3
  • Synonyms
    5430427F17Rik, A530065I17Rik, rc, ruf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442647
    NCBI Gene: 319742
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:45055186-45077436 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22251 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    MPZL3, myelin protein zero like 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MPZL3, myelin protein zero like 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 196264
    neXtProt AC: NX_Q6UWV2
    UniProt: Q6UWV2

  • Chr Location
    11q23.3; chr11:118226690-118252368 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    86 phenotypes from 4 alleles in 5 genetic backgrounds
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele have a rough coat that becomes brittle and oily with age, and display stunted growth, cyclic and progressive hair loss, hyperplastic epidermis, abnormal hair follicles, myocardial degeneration, and reduced collagen and elastin content in the skin and heart.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016706 VEGA Gene Model | MGI Sequence Detail 22251 C57BL/6J ±  kb
transcript OTTMUST00000040478 VEGA | MGI Sequence Detail 3424 Not Applicable  
polypeptide OTTMUSP00000018092 VEGA | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    228 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-13802, MGD-MRK-14253, MGI:1918661, MGI:97880, MGI:98207
References
more
  • Summaries
    All 32
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:243547 Palanza KM, et al., The rough fur (ruf) mutation in mice is an allele of myelin protein zero-like 3 (Mpzl3). Cogent Biology. 2017;3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory