About   Help   FAQ
Mpzl3
Gene Detail
 Symbol
Name
ID
Mpzl3
myelin protein zero-like 3
MGI:2442647
Synonyms 5430427F17Rik, A530065I17Rik, rc
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:45055186-45077436 bp, + strand
From VEGA annotation of GRCm38

  22251 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Mpzl3

Human
homologs
Human Homolog MPZL3, myelin protein zero-like 3
NCBI Gene ID 196264
neXtProt AC  NX_Q6UWV2
Human Chr (Location)  11q23.3; chr11:118226690-118252368 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous allele have a rough coat that becomes brittle and oily with age, and display stunted growth, cyclic and progressive hair loss, hyperplastic epidermis, abnormal hair follicles, myocardial degeneration, and reduced collagen and elastin content in the skin and heart.
 
Phenotype Images(2)
Interactions
Mpzl3 interacts with 292 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cell adhesion, extracellular matrix organization, ...
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000016706 (Evidence)
Ensembl Gene ModelENSMUSG00000070305 (Evidence)
Entrez Gene319742 (Evidence)
DFCITC1606687, TC1663722, TC1678404
DoTSDT.101163829, DT.101350034, DT.527545
Consensus CDS ProjectCCDS40605.1, CCDS52781.1
International Mouse Knockout Project StatusMpzl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016706 VEGA Gene Model | MGI Sequence Detail 22251 C57BL/6J ±  kb
transcript OTTMUST00000040478 VEGA | MGI Sequence Detail 3424 Not Applicable 
polypeptide OTTMUSP00000018092 VEGA | MGI Sequence Detail 237 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR000920 Myelin P0 protein
Protein Ontology PR:000010556 myelin protein zero-like protein 3
References (Earliest) J:13444 Dickie MM, Rough coat. Mouse News Lett. 1966;34:30
(Latest) J:199257 Czyzyk TA, et al., Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis. Am J Physiol Endocrinol Metab. 2013 Jul;305(2):E282-92
All references(31)
Other
accession IDs
MGD-MRK-13802, MGI:1918661, MGI:97880

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory