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Mpzl3 Gene Detail
Summary
  • Symbol
    Mpzl3
  • Name
    myelin protein zero-like 3
  • Synonyms
    5430427F17Rik, A530065I17Rik, rc, ruf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442647
    NCBI Gene: 319742
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45055186-45077436 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442647
protein coding gene Chr9:45055181-45077437 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034728
protein coding gene Chr9:43595421-43618978 (+)
A/J MGP_AJ_G0034709
protein coding gene Chr9:42380150-42402383 (+)
AKR/J MGP_AKRJ_G0034636
protein coding gene Chr9:43255258-43277514 (+)
BALB/cJ MGP_BALBcJ_G0034700
protein coding gene Chr9:42112026-42134257 (+)
C3H/HeJ MGP_C3HHeJ_G0034411
protein coding gene Chr9:43706491-43730590 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035221
protein coding gene Chr9:44875400-44897642 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032136
protein coding gene Chr9:41931340-41953757 (+)
CAST/EiJ MGP_CASTEiJ_G0033733
protein coding gene Chr9:43571975-43594178 (+)
CBA/J MGP_CBAJ_G0034383
protein coding gene Chr9:46523494-46545746 (+)
DBA/2J MGP_DBA2J_G0034542
protein coding gene Chr9:42269174-42291405 (+)
FVB/NJ MGP_FVBNJ_G0034483
protein coding gene Chr9:41526258-41548982 (+)
LP/J MGP_LPJ_G0034623
protein coding gene Chr9:43891191-43916639 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034527
protein coding gene Chr9:48346939-48369172 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035242
protein coding gene Chr9:43173412-43195747 (+)
PWK/PhJ MGP_PWKPhJ_G0033438
protein coding gene Chr9:42155276-42178134 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033274
protein coding gene Chr9:43462678-43485024 (+)
WSB/EiJ MGP_WSBEiJ_G0033846
protein coding gene Chr9:43200428-43222665 (+)



Homology
more
  • Human Ortholog
    MPZL3, myelin protein zero like 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MPZL3, myelin protein zero like 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 196264
    neXtProt AC: NX_Q6UWV2
    UniProt: Q6UWV2

  • Chr Location
    11q23.3; chr11:118226690-118252368 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    89 phenotypes from 4 alleles in 5 genetic backgrounds
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele have a rough coat that becomes brittle and oily with age, and display stunted growth, cyclic and progressive hair loss, hyperplastic epidermis, abnormal hair follicles, myocardial degeneration, and reduced collagen and elastin content in the skin and heart.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070305 Ensembl Gene Model | MGI Sequence Detail 22251 C57BL/6J ±  kb
transcript ENSMUST00000114664 Ensembl | MGI Sequence Detail 3424 Not Applicable  
polypeptide ENSMUSP00000110312 Ensembl | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-13802, MGD-MRK-14253, MGI:1918661, MGI:97880, MGI:98207
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:253459 Inoue SI, et al., Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Hum Mol Genet. 2017 Dec 1;26(23):4715-4727

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory