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Cers6 Gene Detail
Summary
  • Symbol
    Cers6
  • Name
    ceramide synthase 6
  • Synonyms
    4732462C07Rik, CerS6, Lass6, similar to TRH1, T1L
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442564
    NCBI Gene: 241447
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:68861441-69114282 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      252842 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.53 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CERS6, ceramide synthase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CERS6, ceramide synthase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CERS5, LASS6
  • Links
    NCBI Gene ID: 253782
    neXtProt AC: NX_Q6ZMG9
    UniProt: Q6ZMG9

  • Chr Location
    2q24.3; chr2:168456249-168775134 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit hind limb clasping, habituation deficit and altered lipid homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012972 VEGA Gene Model | MGI Sequence Detail 252842 C57BL/6J ±  kb
transcript OTTMUST00000110037 VEGA | MGI Sequence Detail 1279 Not Applicable  
polypeptide OTTMUSP00000061311 VEGA | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1972 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139372
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:232720 Sassa T, et al., Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. J Biol Chem. 2016 Apr 1;291(14):7477-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory