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Cers6 Gene Detail
Summary
  • Symbol
    Cers6
  • Name
    ceramide synthase 6
  • Synonyms
    4732462C07Rik, CerS6, Lass6, similar to TRH1, T1L
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442564
    NCBI Gene: 241447
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:68861441-69114282 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      252842 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.53 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CERS6, ceramide synthase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CERS6, ceramide synthase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CERS5, LASS6
  • Links
    NCBI Gene ID: 253782
    neXtProt AC: NX_Q6ZMG9
    UniProt: Q6ZMG9

  • Chr Location
    2q24.3; chr2:168456249-168775134 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit hind limb clasping, habituation deficit and altered lipid homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012972 VEGA Gene Model | MGI Sequence Detail 252842 C57BL/6J ±  kb
    transcript OTTMUST00000110037 VEGA | MGI Sequence Detail 1279 Not Applicable  
    polypeptide OTTMUSP00000061311 VEGA | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1972 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
    • InterPro Domains
      IPR001356 Homeobox domain
      IPR009057 Homeobox-like domain superfamily
      IPR016439 Sphingosine N-acyltransferase Lag1/Lac1-like
      IPR006634 TRAM/LAG1/CLN8 homology domain
    Molecular
    Reagents
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    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139372
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:259676 Helke K, et al., Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep. 2018 Jan 26;8(1):1627

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory