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Aasdh Gene Detail
Summary
  • Symbol
    Aasdh
  • Name
    aminoadipate-semialdehyde dehydrogenase
  • Synonyms
    A230062G08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442517
    NCBI Gene: 231326
Location & Maps
more
  • Sequence Map
    Chr5:76873659-76905514 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31856 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 41.45 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    AASDH, aminoadipate-semialdehyde dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AASDH, aminoadipate-semialdehyde dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACSF4, LYS2, NRPS1098, NRPS998
  • Links
    NCBI Gene ID: 132949
    neXtProt AC: NX_Q4L235

  • Chr Location
    4q12; chr4:56337687-56389418 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 71711
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: AASDH
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    2
  • Gene trapped
    19
  • Spontaneous
    1
  • Genomic Mutations
    3 involving Aasdh
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026517 VEGA Gene Model | MGI Sequence Detail 31856 C57BL/6J ±  kb
transcript OTTMUST00000065592 VEGA | MGI Sequence Detail 3694 Not Applicable  
polypeptide OTTMUSP00000032707 VEGA | MGI Sequence Detail 1100 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    201 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000003530 acyl-CoA synthetase family member 4
  • EC
  • InterPro Domains
    IPR020845 AMP-binding, conserved site
    IPR000873 AMP-dependent synthetase/ligase
    IPR006162 Phosphopantetheine attachment site
    IPR009081 Phosphopantetheine binding ACP domain
    IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
    IPR025666 Pyrrolo-quinoline quinone-like domain
    IPR002372 Pyrrolo-quinoline quinone repeat
    IPR027295 Quinoprotein alcohol dehydrogenase-like domain
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:219985 Drozak J, et al., Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a beta-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase. FEBS J. 2014 Mar;281(6):1585-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory