Arhgef9
Gene Detail

Symbol Name ID

Arhgef9 CDC42 guanine nucleotide exchange factor (GEF) 9 MGI:2442233

Synonyms

9630036L12Rik, collybistin, mKIAA0424

Feature Type

protein coding gene

Genetic Map

Chromosome X

41.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:95048937-95196821 bp, - strand From VEGA annotation of GRCm38   147885 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Arhgef9

Human homologs

Human Homolog		ARHGEF9, Cdc42 guanine nucleotide exchange factor (GEF) 9
NCBI Gene ID		23229
neXtProt AC		NX_O43307
Human Synonyms		COLLYBISTIN, EIEE8, HPEM-2, PEM2, PEM-2
Human Chr (Location)		Xq11.1; chrX:62854848-63005426 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ARHGEF9

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Male mice hemizygous for a null allele exhibit impaired spatial learning, increased anxiety-associated behaviors, and altered central nervous system synaptic transmission.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	receptor clustering, regulation of catalytic activity, ...
Component	cell cortex, cytoplasm
Function	guanyl-nucleotide exchange factor activity, phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (53)    Tissues (26)   
Theiler Stages: 10, 18, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	45
Northern blot	4
RT-PCR	4

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000018030 (Evidence)
Ensembl Gene Model	ENSMUSG00000025656 (Evidence)
Entrez Gene	236915 (Evidence)
DFCI	TC1598463, TC1606598, TC1656514, TC1658974
DoTS	DT.101735651, DT.101735652, DT.55201074, DT.99712660
NIA Mouse Gene Index	U039545
Consensus CDS Project	CCDS53137.1
International Mouse Knockout Project Status	Arhgef9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018030	VEGA Gene Model | MGI Sequence Detail	147885	C57BL/6J
transcript	OTTMUST00000043535	VEGA | MGI Sequence Detail	3772	Not Applicable
polypeptide	OTTMUSP00000019570	VEGA | MGI Sequence Detail	560	Not Applicable

All sequences(62) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(158 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000004261	rho guanine nucleotide exchange factor 9

References

(Earliest) J:88599 Kneussel M, et al., Distribution of transcripts for the brain-specific GDP/GTP exchange factor collybistin in the developing mouse brain. Eur J Neurosci. 2001 Feb;13(3):487-92
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)