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Arhgef9
Gene Detail
 Symbol
Name
ID
Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
MGI:2442233
Synonyms 9630036L12Rik, collybistin, mKIAA0424
Feature Type protein coding gene
Genetic Map
Chromosome X
41.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:95048935-95196821 bp, - strand
From VEGA annotation of GRCm38

  147887 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Gene Tree: Arhgef9

Human
homologs
Human Homolog ARHGEF9, Cdc42 guanine nucleotide exchange factor (GEF) 9
NCBI Gene ID 23229
neXtProt AC  NX_O43307
Human Synonyms  COLLYBISTIN, EIEE8, HPEM-2, PEM2, PEM-2
Human Chr (Location)  Xq11.1; chrX:63634967-63785546 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARHGEF9
Alleles
and
phenotypes
All alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from APF )
 
Male mice hemizygous for a null allele exhibit impaired spatial learning, increased anxiety-associated behaviors, and altered central nervous system synaptic transmission.
 
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process positive regulation of GTPase activity, receptor clustering, ...
Component cell cortex, cytoplasm
Function guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (53)    Tissues (26)   
Theiler Stages: 10, 18, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 45
Northern blot 4
RT-PCR 4
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000018030 (Evidence)
Ensembl Gene ModelENSMUSG00000025656 (Evidence)
Entrez Gene236915 (Evidence)
DFCITC1598463, TC1606598, TC1656514, TC1658974
DoTSDT.101735651, DT.101735652, DT.55201074, DT.99712660, DT.99854732
NIA Mouse Gene IndexU039545
Consensus CDS ProjectCCDS53137.1, CCDS72409.1
International Mouse Knockout Project StatusArhgef9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018030 VEGA Gene Model | MGI Sequence Detail 147887 C57BL/6J ±  kb
transcript OTTMUST00000043535 VEGA | MGI Sequence Detail 3772 Not Applicable 
polypeptide OTTMUSP00000019570 VEGA | MGI Sequence Detail 560 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(15) UniProt(7)
Polymorphisms SNPs within 2kb(210 from dbSNP Build 137)    SNPs within 2kb including multiple locations(212)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004261 rho guanine nucleotide exchange factor 9
References (Earliest) J:88599 Kneussel M, et al., Distribution of transcripts for the brain-specific GDP/GTP exchange factor collybistin in the developing mouse brain. Eur J Neurosci. 2001 Feb;13(3):487-92
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory