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Arhgef9
Gene Detail
Symbol

Name
ID
Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
MGI:2442233
Synonyms
9630036L12Rik, collybistin, mKIAA0424
Feature Type
protein coding gene
Genetic Map
Chromosome X
41.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:95048935-95196821 bp, - strand
From VEGA annotation of GRCm38

  147887 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: ARHGEF9
Gene Tree: Arhgef9

Human
homologs
ARHGEF9, Cdc42 guanine nucleotide exchange factor (GEF) 9
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23229
neXtProt AC: NX_O43307

Human Synonyms: COLLYBISTIN, EIEE8, HPEM-2, PEM2, PEM-2

Human Chr (Location): Xq11.1; chrX:63634967-63785546 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ARHGEF9

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from APF )
 
Male mice hemizygous for a null allele exhibit impaired spatial learning, increased anxiety-associated behaviors, and altered central nervous system synaptic transmission.
 
Interactions
Arhgef9 interacts with 377 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (53)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
Northern blot 4
RT-PCR 4
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arhgef9 ; ZFIN arhgef9, arhgef9b    NEW 
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000018030 (Evidence)
Ensembl Gene Model ENSMUSG00000025656 (Evidence)
Entrez Gene 236915 (Evidence)
DFCI TC1606598, TC1598463, TC1656514, TC1658974
DoTS DT.101735652, DT.101735651, DT.99854732, DT.99712660, DT.55201074
NIA Mouse Gene Index U039545
Consensus CDS Project CCDS53137.1, CCDS72409.1
International Mouse Phenotyping Consortium Status Arhgef9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018030 VEGA Gene Model | MGI Sequence Detail 147887 C57BL/6J ±  kb
transcript OTTMUST00000043535 VEGA | MGI Sequence Detail 3772 Not Applicable 
polypeptide OTTMUSP00000019570 VEGA | MGI Sequence Detail 560 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(16) UniProt(7)
Polymorphisms
SNPs within 2kb(210 from dbSNP Build 137)    SNPs within 2kb including multiple locations(212)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004261 rho guanine nucleotide exchange factor 9
References
(Earliest) J:88599 Kneussel M, et al., Distribution of transcripts for the brain-specific GDP/GTP exchange factor collybistin in the developing mouse brain. Eur J Neurosci. 2001 Feb;13(3):487-92
(Latest) J:216073 Soykan T, et al., A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. EMBO J. 2014 Sep 17;33(18):2113-33
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory