Gimap5 Gene Detail

Summary

• Symbol
  Gimap5
• Name
  GTPase, IMAP family member 5
• Synonyms
  E230026N22Rik

• Feature Type
  protein coding gene
• IDs
  MGI:2442232
  NCBI Gene: 317757
• Gene Overview
  MyGene.info: GIMAP5
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr6:48746197-48754210 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 23.71 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  58 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442232	protein coding gene	Chr6:48746136-48754210 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0030711	protein coding gene	Chr6:47703587-47712980 (+)
A/J	MGP_AJ_G0030682	protein coding gene	Chr6:45538551-45546650 (+)
AKR/J	MGP_AKRJ_G0030607	protein coding gene	Chr6:47136481-47147455 (+)
BALB/cJ	MGP_BALBcJ_G0030692	protein coding gene	Chr6:45869861-45878905 (+)
C3H/HeJ	MGP_C3HHeJ_G0030405	protein coding gene	Chr6:47147031-47155500 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031147	protein coding gene	Chr6:48824847-48834575 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028354	protein coding gene	Chr6:43165672-43173796 (+)
CAST/EiJ	MGP_CASTEiJ_G0029809	protein coding gene	Chr6:46868143-46876592 (+)
CBA/J	MGP_CBAJ_G0030380	protein coding gene	Chr6:50846911-50856506 (+)
DBA/2J	MGP_DBA2J_G0030529	protein coding gene	Chr6:45454302-45461796 (+)
FVB/NJ	MGP_FVBNJ_G0030481	protein coding gene	Chr6:45087856-45096247 (+)
LP/J	MGP_LPJ_G0030614	protein coding gene	Chr6:47686526-47697892 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030515	protein coding gene	Chr6:53660461-53668328 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031176	protein coding gene	Chr6:47005157-47014199 (+)
PWK/PhJ	MGP_PWKPhJ_G0029521	protein coding gene	Chr6:44986528-44998212 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029357	protein coding gene	Chr6:46350261-46358924 (+)
WSB/EiJ	MGP_WSBEiJ_G0029886	protein coding gene	Chr6:47005391-47014506 (+)

Homology

• Human Ortholog
  GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough

• Vertebrate Orthologs
  11

• Human Ortholog
  GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
  Orthology source: HomoloGene
• Links
  HGNC:51257

  NCBI Gene ID: 100527949

  
  
• Chr Location
  7q36.1; chr7:150716557-150743649 (+)  GRCh38.p7

---

• Human Ortholog
  GIMAP5, GTPase, IMAP family member 5
  Orthology source: HGNC
• Synonyms
  HIMAP3, IAN4, IAN4L1, IAN5, IAN-5, IMAP3, IROD
• Links
  HGNC:18005

  NCBI Gene ID: 55340

  neXtProt AC: NX_Q96F15

  UniProt: Q96F15

  
  
• Chr Location
  7q36.1; chr7:150737348-150743649 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 41257
  1 human;2 mouse;1 rat;1 chimpanzee;2 cattle;1 dog;2 chicken;1 macaque, rhesus
  
• HCOP
  human homology predictions: GIMAP1-GIMAP5, GIMAP5
• Gene Tree
  Gimap5
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  67 phenotypes from 2 alleles in 3 genetic backgrounds
  2 phenotypes from multigenic genotypes
  10 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (ENU)
  1
• Targeted
  6
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  8 strains or lines available

Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  11
• GO References
  5

• External Resources
  FuncBase

Expression

• cDNA Data
  14

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Gimap5 interacts with 128 markers (Mir7-1, Mir10a, Mir10b, ...) View All

Sequences &
Gene Models

• All Sequences
  49
• RefSeq
  12
• UniProt
  1
• CCDS
  CCDS20114.1
• UniGene
  455917

• Ensembl
  ENSMUSG00000043505 (Evidence)
• NCBI Gene
  317757

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000043505	Ensembl Gene Model | MGI Sequence Detail	8014	C57BL/6J
transcript	ENSMUST00000055558	Ensembl | MGI Sequence Detail	1953	Not Applicable
polypeptide	ENSMUSP00000056820	Ensembl | MGI Sequence Detail	308	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR006703 AIG1-type guanine nucleotide-binding (G) domain
  IPR027417 P-loop containing nucleoside triphosphate hydrolase

Molecular
Reagents

• All nucleic 14

  cDNA 14

  
  

  Microarray probesets 3

References

• Summaries
  All 31

  Gene Ontology 5

  Phenotypes 10
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:260013 Patterson AR, et al., Gimap5-dependent inactivation of GSK3beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Nat Commun. 2018 Jan 30;9(1):430

TSS for Gimap5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56207	Chr6:48746169-48746180 (+)	-22 bp
Tssr56208	Chr6:48746188-48746212 (+)	3 bp
Tssr56209	Chr6:48746223-48746234 (+)	32 bp
Tssr56210	Chr6:48746237-48746302 (+)	73 bp
Tssr56211	Chr6:48746707-48746718 (+)	516 bp