About   Help   FAQ
Gimap5 Gene Detail
Summary
  • Symbol
    Gimap5
  • Name
    GTPase, IMAP family member 5
  • Synonyms
    E230026N22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442232
    NCBI Gene: 317757
  • Gene Overview
    MyGene.info: GIMAP5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48746197-48754210 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 23.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442232
protein coding gene Chr6:48746136-48754210 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030711
protein coding gene Chr6:47703587-47712980 (+)
A/J MGP_AJ_G0030682
protein coding gene Chr6:45538551-45546650 (+)
AKR/J MGP_AKRJ_G0030607
protein coding gene Chr6:47136481-47147455 (+)
BALB/cJ MGP_BALBcJ_G0030692
protein coding gene Chr6:45869861-45878905 (+)
C3H/HeJ MGP_C3HHeJ_G0030405
protein coding gene Chr6:47147031-47155500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031147
protein coding gene Chr6:48824847-48834575 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028354
protein coding gene Chr6:43165672-43173796 (+)
CAST/EiJ MGP_CASTEiJ_G0029809
protein coding gene Chr6:46868143-46876592 (+)
CBA/J MGP_CBAJ_G0030380
protein coding gene Chr6:50846911-50856506 (+)
DBA/2J MGP_DBA2J_G0030529
protein coding gene Chr6:45454302-45461796 (+)
FVB/NJ MGP_FVBNJ_G0030481
protein coding gene Chr6:45087856-45096247 (+)
LP/J MGP_LPJ_G0030614
protein coding gene Chr6:47686526-47697892 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030515
protein coding gene Chr6:53660461-53668328 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031176
protein coding gene Chr6:47005157-47014199 (+)
PWK/PhJ MGP_PWKPhJ_G0029521
protein coding gene Chr6:44986528-44998212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029357
protein coding gene Chr6:46350261-46358924 (+)
WSB/EiJ MGP_WSBEiJ_G0029886
protein coding gene Chr6:47005391-47014506 (+)



Homology
more
  • Human Ortholog
    GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 100527949

  • Chr Location
    7q36.1; chr7:150716557-150743649 (+)  GRCh38.p7

  • Human Ortholog
    GIMAP5, GTPase, IMAP family member 5
    Orthology source: HGNC
  • Synonyms
    HIMAP3, IAN4, IAN4L1, IAN5, IAN-5, IMAP3, IROD
  • Links
    NCBI Gene ID: 55340
    neXtProt AC: NX_Q96F15
    UniProt: Q96F15

  • Chr Location
    7q36.1; chr7:150737348-150743649 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043505 Ensembl Gene Model | MGI Sequence Detail 8014 C57BL/6J ±  kb
transcript ENSMUST00000055558 Ensembl | MGI Sequence Detail 1953 Not Applicable  
polypeptide ENSMUSP00000056820 Ensembl | MGI Sequence Detail 308 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR006703 AIG1-type guanine nucleotide-binding (G) domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:260013 Patterson AR, et al., Gimap5-dependent inactivation of GSK3beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Nat Commun. 2018 Jan 30;9(1):430

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory