Gimap5 MGI Mouse Gene Detail - MGI:2442232 - GTPase, IMAP family member 5

Symbol

Gimap5
Name

GTPase, IMAP family member 5
Synonyms

E230026N22Rik

Feature Type

protein coding gene
IDs

MGI:2442232
NCBI Gene: 317757
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:48723131-48731134 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.71 cM
Mapping Data

1 experiment

SNPs within 2kb

368 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442232	protein coding gene	Chr6:48723131-48731144 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030711	protein coding gene	Chr6:47703587-47712980 (+)
A/J	MGP_AJ_G0030682	protein coding gene	Chr6:45538551-45546650 (+)
AKR/J	MGP_AKRJ_G0030607	protein coding gene	Chr6:47136481-47147455 (+)
BALB/cJ	MGP_BALBcJ_G0030692	protein coding gene	Chr6:45869861-45878905 (+)
C3H/HeJ	MGP_C3HHeJ_G0030405	protein coding gene	Chr6:47147031-47155500 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031147	protein coding gene	Chr6:48824847-48834575 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028354	protein coding gene	Chr6:43165672-43173796 (+)
CAST/EiJ	MGP_CASTEiJ_G0029809	protein coding gene	Chr6:46868143-46876592 (+)
CBA/J	MGP_CBAJ_G0030380	protein coding gene	Chr6:50846911-50856506 (+)
DBA/2J	MGP_DBA2J_G0030529	protein coding gene	Chr6:45454302-45461796 (+)
FVB/NJ	MGP_FVBNJ_G0030481	protein coding gene	Chr6:45087856-45096247 (+)
LP/J	MGP_LPJ_G0030614	protein coding gene	Chr6:47686526-47697892 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030515	protein coding gene	Chr6:53660461-53668328 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031176	protein coding gene	Chr6:47005157-47014199 (+)
PWK/PhJ	MGP_PWKPhJ_G0029521	protein coding gene	Chr6:44986528-44998212 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029357	protein coding gene	Chr6:46350261-46358924 (+)
WSB/EiJ	MGP_WSBEiJ_G0029886	protein coding gene	Chr6:47005391-47014506 (+)

Human Ortholog

GIMAP5, GTPase, IMAP family member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GIMAP5, GTPase, IMAP family member 5
Synonyms

HIMAP3, IAN4, IAN4L1, IAN-5, IAN5, IMAP3, IROD, NCPH2
Links

HGNC:18005

NCBI Gene ID: 55340

UniProt: Q96F15
Chr Location

7q36.1; chr7:150722253-150750033 (+) GRCh38

MGI Vertebrate Homology

Gimap5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GIMAP5
Gene Tree

Gimap5

Diseases

1 with human GIMAP5 associations

				Human Disease	Mouse Models
				portal hypertension IDs portal hypertension DOID:10762 ICD10CM:K76.6 ICD9CM:572.3 MESH:D006975 NCI:C3119 UMLS_CUI:C0020541

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

71 phenotypes from 3 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Endonuclease-mediated

1
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis.

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All GO Annotations

30
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS20114.1

Ensembl

ENSMUSG00000043505 (Evidence)
NCBI Gene

317757

			Length	Strain/Species	Flank
genomic	317757	NCBI Gene Model \| MGI Sequence Detail	8004	C57BL/6J	± kb
transcript	NM_175035	RefSeq \| MGI Sequence Detail	1943	C57BL/6
polypeptide	Q8BWF2	UniProt \| EBI \| MGI Sequence Detail	308	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR006703 AIG1-type guanine nucleotide-binding (G) domain

IPR045058 GTPase GIMA/IAN/Toc

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 14

cDNA 14

Microarray probesets 3

Summaries

All 34

Gene Ontology 6

Phenotypes 13
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:355744 Drzewiecki K, et al., GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension. J Exp Med. 2021 Jul 5;218(7)

TSS for Gimap5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56207	Chr6:48723103-48723114 (+)	-22 bp
Tssr56208	Chr6:48723122-48723146 (+)	3 bp
Tssr56209	Chr6:48723157-48723168 (+)	32 bp
Tssr56210	Chr6:48723171-48723236 (+)	73 bp
Tssr56211	Chr6:48723641-48723652 (+)	516 bp
Tssr56212	Chr6:48724858-48724891 (+)	1,744 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24