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Gimap5
Gene Detail
 Symbol
Name
ID
Gimap5
GTPase, IMAP family member 5
MGI:2442232
Synonyms E230026N22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
23.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:48746197-48754210 bp, + strand
From VEGA annotation of GRCm38

  8014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41257  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 2 chicken

Gene Tree: Gimap5

Human
homologs
Human Homolog GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
NCBI Gene ID 100527949
Human Chr (Location)  7q; chr7:150716557-150743649 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis.
 
Interactions
Gimap5 interacts with 129 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Component integral component of membrane, lysosome, ...
Function GTP binding, nucleotide binding
External Resources: FuncBase
Expression
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026930 (Evidence)
Ensembl Gene ModelENSMUSG00000043505 (Evidence)
Entrez Gene317757 (Evidence)
UniGene455917
DFCITC1584584, TC1599160, TC1628452
DoTSDT.40180190, DT.87025704, DT.94354785
Consensus CDS ProjectCCDS20114.1
International Mouse Knockout Project StatusGimap5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026930 VEGA Gene Model | MGI Sequence Detail 8014 C57BL/6J ±  kb
transcript OTTMUST00000066585 VEGA | MGI Sequence Detail 1953 Not Applicable 
polypeptide OTTMUSP00000033393 VEGA | MGI Sequence Detail 308 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(14) UniProt(1)
Polymorphisms SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006703 AIG1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000007979 GTPase IMAP family member 5
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:180453 Aksoylar HI, et al., Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. J Immunol. 2012 Jan 1;188(1):146-54
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory