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Gimap5 Gene Detail
Summary
  • Symbol
    Gimap5
  • Name
    GTPase, IMAP family member 5
  • Synonyms
    E230026N22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442232
    NCBI Gene: 317757
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr6:48746197-48754210 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      8014 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.71 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 100527949

  • Chr Location
    7q36.1; chr7:150716557-150743649 (+)  GRCh38.p7
  • Human Ortholog
    GIMAP5, GTPase, IMAP family member 5
    Orthology source: HGNC
  • Synonyms
    HIMAP3, IAN4, IAN4L1, IAN5, IAN-5, IMAP3, IROD
  • Links
    NCBI Gene ID: 55340
    neXtProt AC: NX_Q96F15
    UniProt: Q96F15

  • Chr Location
    7q36.1; chr7:150737348-150743649 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    13
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026930 VEGA Gene Model | MGI Sequence Detail 8014 C57BL/6J ±  kb
transcript OTTMUST00000066585 VEGA | MGI Sequence Detail 1953 Not Applicable  
polypeptide OTTMUSP00000033393 VEGA | MGI Sequence Detail 308 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    58 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR006703 AIG1-type guanine nucleotide-binding (G) domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:260013 Patterson AR, et al., Gimap5-dependent inactivation of GSK3beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Nat Commun. 2018 Jan 30;9(1):430
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory