Gimap5
Gene Detail

Symbol

Name
ID

Gimap5
GTPase, IMAP family member 5
MGI:2442232

Synonyms

E230026N22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6
23.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:48746197-48754210 bp, + strand From VEGA annotation of GRCm38   8014 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:41257  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 2 chicken

Gene Tree: Gimap5

Human
homologs

Human Homolog		GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
NCBI Gene ID		100527949
Human Chr (Location)		7q; chr7:150716557-150743649 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis.

 

Interactions

Gimap5 interacts with 129 markers (Mir7-1, Mir10a, Mir10b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (8 annotations)

Component	integral component of membrane, lysosome, ...
Function	GTP binding, nucleotide binding

External Resources: FuncBase

Expression

cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(13) cDNA(13)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000026930 (Evidence)
Ensembl Gene Model	ENSMUSG00000043505 (Evidence)
Entrez Gene	317757 (Evidence)
UniGene	455917
DFCI	TC1584584, TC1628452, TC1599160
DoTS	DT.94354785, DT.87025704, DT.40180190
Consensus CDS Project	CCDS20114.1
International Mouse Knockout Project Status	Gimap5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026930	VEGA Gene Model | MGI Sequence Detail	8014	C57BL/6J
transcript	OTTMUST00000066585	VEGA | MGI Sequence Detail	1953	Not Applicable
polypeptide	OTTMUSP00000033393	VEGA | MGI Sequence Detail	308	Not Applicable

All sequences(40) RefSeq(11) UniProt(1)

Polymorphisms

SNPs within 2kb(58 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR006703	AIG1
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000007979	GTPase IMAP family member 5

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:180453 Aksoylar HI, et al., Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. J Immunol. 2012 Jan 1;188(1):146-54
All references(29)