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Gimap5 Gene Detail
Summary
  • Symbol
    Gimap5
  • Name
    GTPase, IMAP family member 5
  • Synonyms
    E230026N22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442232
    NCBI Gene: 317757
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48723131-48731134 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 23.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442232
protein coding gene Chr6:48723131-48731144 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030711
protein coding gene Chr6:47703587-47712980 (+)
A/J MGP_AJ_G0030682
protein coding gene Chr6:45538551-45546650 (+)
AKR/J MGP_AKRJ_G0030607
protein coding gene Chr6:47136481-47147455 (+)
BALB/cJ MGP_BALBcJ_G0030692
protein coding gene Chr6:45869861-45878905 (+)
C3H/HeJ MGP_C3HHeJ_G0030405
protein coding gene Chr6:47147031-47155500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031147
protein coding gene Chr6:48824847-48834575 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028354
protein coding gene Chr6:43165672-43173796 (+)
CAST/EiJ MGP_CASTEiJ_G0029809
protein coding gene Chr6:46868143-46876592 (+)
CBA/J MGP_CBAJ_G0030380
protein coding gene Chr6:50846911-50856506 (+)
DBA/2J MGP_DBA2J_G0030529
protein coding gene Chr6:45454302-45461796 (+)
FVB/NJ MGP_FVBNJ_G0030481
protein coding gene Chr6:45087856-45096247 (+)
LP/J MGP_LPJ_G0030614
protein coding gene Chr6:47686526-47697892 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030515
protein coding gene Chr6:53660461-53668328 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031176
protein coding gene Chr6:47005157-47014199 (+)
PWK/PhJ MGP_PWKPhJ_G0029521
protein coding gene Chr6:44986528-44998212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029357
protein coding gene Chr6:46350261-46358924 (+)
WSB/EiJ MGP_WSBEiJ_G0029886
protein coding gene Chr6:47005391-47014506 (+)



Homology
more
  • Human Ortholog
    GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
  • Links
    NCBI Gene ID: 100527949

  • Chr Location
    7q36.1; chr7:150716613-150743646 (+)  GRCh38

  • Human Ortholog
    GIMAP5, GTPase, IMAP family member 5
  • Synonyms
    HIMAP3, IAN4, IAN4L1, IAN5, IAN-5, IMAP3, IROD, NCPH2
  • Links
    NCBI Gene ID: 55340
    neXtProt AC: NX_Q96F15
    UniProt: Q96F15

  • Chr Location
    7q36.1; chr7:150722253-150750033 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human GIMAP5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 317757 NCBI Gene Model | MGI Sequence Detail 8004 C57BL/6J ±  kb
    transcript NM_175035 RefSeq | MGI Sequence Detail 1943 C57BL/6  
    polypeptide Q8BWF2 UniProt | EBI | MGI Sequence Detail 308 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR006703 AIG1-type guanine nucleotide-binding (G) domain
      IPR045058 GTPase GIMA/IAN/Toc
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:273040 Patterson AR, et al., Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4(+) T-cell development and allergic airway disease. J Allergy Clin Immunol. 2019 Jan;143(1):245-257.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory