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Dusp4 Gene Detail
Summary
  • Symbol
    Dusp4
  • Name
    dual specificity phosphatase 4
  • Synonyms
    2700078F24Rik, E130306H24Rik, MKP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442191
    NCBI Gene: 319520
  • Gene Overview
    MyGene.info: DUSP4
Location & Maps
more
  • Sequence Map
    Chr8:34807297-34819894 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12598 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DUSP4, dual specificity phosphatase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP4, dual specificity phosphatase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HVH2, MKP2, MKP-2, TYP
  • Links
    NCBI Gene ID: 1846
    neXtProt AC: NX_Q13115

  • Chr Location
    8p12-p11; chr8:29333062-29350750 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit a decrease in B cell apoptosis of bone marrow-derived, IL-7-dependent pro-B lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016984 VEGA Gene Model | MGI Sequence Detail 12598 C57BL/6J ±  kb
transcript OTTMUST00000041196 VEGA | MGI Sequence Detail 2740 Not Applicable  
polypeptide OTTMUSP00000018459 VEGA | MGI Sequence Detail 398 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    154 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006754 dual specificity protein phosphatase 4
  • EC
  • InterPro Domains
    IPR024950 Dual specificity phosphatase
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR029021 Protein-tyrosine phosphatase-like
    IPR001763 Rhodanese-like domain
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
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MGI:1917486, MGI:2142625, MGI:2142829
References
more
  • Summaries
    All 50
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:214504 Woods S, et al., MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice. PLoS Pathog. 2013 Aug;9(8):e1003535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory