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Dusp4
Gene Detail
Symbol

Name
ID
Dusp4
dual specificity phosphatase 4
MGI:2442191
Synonyms
2700078F24Rik, E130306H24Rik, MKP2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
21.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:34807297-34819894 bp, + strand
From VEGA annotation of GRCm38

  12598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DUSP4
Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp4

Human
homologs
DUSP4, dual specificity phosphatase 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1846
neXtProt AC: NX_Q13115

Human Synonyms: HVH2, MKP2, MKP-2, TYP

Human Chr (Location): 8p12-p11; chr8:29333062-29350750 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit a decrease in B cell apoptosis of bone marrow-derived, IL-7-dependent pro-B lymphocytes.
 
Interactions
Dusp4 interacts with 170 markers (Mir7-2, Mir7b, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process dephosphorylation, endoderm formation, ...
Component nucleoplasm, nucleus
Function hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (104)    Tissues (52)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 104
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dusp4 ; ZFIN dusp4    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016984 (Evidence)
Ensembl Gene Model ENSMUSG00000031530 (Evidence)
Entrez Gene 319520 (Evidence)
DFCI TC1608176, TC1582437
DoTS DT.490828, DT.87049241
NIA Mouse Gene Index U195777, U009254
EC 3.1.3.48, 3.1.3.16
Consensus CDS Project CCDS22241.1
International Mouse Phenotyping Consortium Status Dusp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016984 VEGA Gene Model | MGI Sequence Detail 12598 C57BL/6J ±  kb
transcript OTTMUST00000041196 VEGA | MGI Sequence Detail 2740 Not Applicable 
polypeptide OTTMUSP00000018459 VEGA | MGI Sequence Detail 398 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000006754 dual specificity protein phosphatase 4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214504 Woods S, et al., MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice. PLoS Pathog. 2013 Aug;9(8):e1003535
All references(52)
Other
accession IDs
MGI:1917486, MGI:2142625, MGI:2142829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory