Dusp4
Gene Detail

Symbol Name ID

Dusp4 dual specificity phosphatase 4 MGI:2442191

Synonyms

2700078F24Rik, E130306H24Rik, MKP2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

21.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:34807297-34819894 bp, + strand From VEGA annotation of GRCm38   12598 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp4

Human homologs

Human Homolog		DUSP4, dual specificity phosphatase 4
NCBI Gene ID		1846
neXtProt AC		NX_Q13115
Human Synonyms		HVH2, MKP2, MKP-2, TYP
Human Chr (Location)		8p12-p11; chr8:29190579-29208267 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a null allele exhibit a decrease in B cell apoptosis of bone marrow-derived, IL-7-dependent pro-B lymphocytes.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	dephosphorylation, endoderm formation, ...
Component	nucleoplasm, nucleus
Function	hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (104)    Tissues (52)    Images (32)
Theiler Stages: 19, 20, 22, 23, 24

Assay Type	Results
RNA in situ	104

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(8)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016984 (Evidence)
Ensembl Gene Model	ENSMUSG00000031530 (Evidence)
Entrez Gene	319520 (Evidence)
DFCI	TC1582437, TC1608176
DoTS	DT.490828, DT.87049241
NIA Mouse Gene Index	U009254, U195777
EC	3.1.3.16, 3.1.3.48
Consensus CDS Project	CCDS22241.1
International Mouse Knockout Project Status	Dusp4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016984	VEGA Gene Model | MGI Sequence Detail	12598	C57BL/6J
transcript	OTTMUST00000041196	VEGA | MGI Sequence Detail	2740	Not Applicable
polypeptide	OTTMUSP00000018459	VEGA | MGI Sequence Detail	398	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(77 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024950	Dual specificity phosphatase
InterPro	IPR000340	Dual specificity phosphatase, catalytic domain
InterPro	IPR020422	Dual specificity phosphatase, subgroup, catalytic domain
InterPro	IPR008343	Mitogen-activated protein (MAP) kinase phosphatase
InterPro	IPR000387	Protein-tyrosine/Dual-specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR001763	Rhodanese-like domain
Protein Ontology	PR:000006754	dual specificity protein phosphatase 4

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:180366 Huang CY, et al., DUSP4 deficiency enhances CD25 expression and CD4(+) T-cell proliferation without impeding T-cell development. Eur J Immunol. 2012 Feb;42(2):476-88
All references(49)

Other accession IDs

MGI:1917486, MGI:2142625, MGI:2142829