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Dusp4
Gene Detail
 Symbol
Name
ID
Dusp4
dual specificity phosphatase 4
MGI:2442191
Synonyms 2700078F24Rik, E130306H24Rik, MKP2
Feature Type protein coding gene
Genetic Map
Chromosome 8
21.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:34807297-34819894 bp, + strand
From VEGA annotation of GRCm38

  12598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp4

Human
homologs
Human Homolog DUSP4, dual specificity phosphatase 4
NCBI Gene ID 1846
neXtProt AC  NX_Q13115
Human Synonyms  HVH2, MKP2, MKP-2, TYP
Human Chr (Location)  8p12-p11; chr8:29333062-29350750 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit a decrease in B cell apoptosis of bone marrow-derived, IL-7-dependent pro-B lymphocytes.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process dephosphorylation, endoderm formation, ...
Component nucleus
Function hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (104)    Tissues (52)    Images (32)
Theiler Stages: 19, 20, 22, 23, 24
Assay TypeResults
RNA in situ 104
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016984 (Evidence)
Ensembl Gene ModelENSMUSG00000031530 (Evidence)
Entrez Gene319520 (Evidence)
DFCITC1582437, TC1608176
DoTSDT.490828, DT.87049241
NIA Mouse Gene IndexU009254, U195777
EC3.1.3.16, 3.1.3.48
Consensus CDS ProjectCCDS22241.1
International Mouse Knockout Project StatusDusp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016984 VEGA Gene Model | MGI Sequence Detail 12598 C57BL/6J ±  kb
transcript OTTMUST00000041196 VEGA | MGI Sequence Detail 2740 Not Applicable 
polypeptide OTTMUSP00000018459 VEGA | MGI Sequence Detail 398 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000006754 dual specificity protein phosphatase 4
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200367 Auger-Messier M, et al., Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy. Circ Res. 2013 Jan 4;112(1):48-56
All references(52)
Other
accession IDs
MGI:1917486, MGI:2142625, MGI:2142829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory