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G3bp2
Gene Detail
 Symbol
Name
ID
G3bp2
GTPase activating protein (SH3 domain) binding protein 2
MGI:2442040
Synonyms E430034L04Rik, G3BP, G3BP2
Feature Type protein coding gene
Genetic Map
Chromosome 5
45.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:92052146-92083735 bp, - strand
From NCBI annotation of GRCm38

  31590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137244  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: G3bp2

Human
homologs
Human Homolog G3BP2, GTPase activating protein (SH3 domain) binding protein 2
NCBI Gene ID 9908
neXtProt AC  NX_Q9UN86
Human Chr (Location)  4q21.1; chr4:75642769-75724525 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(234) : Gene trapped(232) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
G3bp2 interacts with 438 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process mRNA transport, small GTPase mediated signal transduction, ...
Component cytoplasm, intracellular
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (23)    Tissues (23)    Images (3)
Theiler Stages: 21, 28
Assay TypeResults
RNA in situ 21
RT-PCR 2
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000029405 (Evidence)
Entrez Gene23881 (Evidence)
DFCITC1573288, TC1584448, TC1603716, TC1632949, TC1664723, TC1675054
DoTSDT.101149021, DT.101398213, DT.101704781, DT.103577956, DT.110681713, DT.55162818, DT.55201207, DT.94400190, DT.94400480, DT.97401142
NIA Mouse Gene IndexU026400, U145146
Consensus CDS ProjectCCDS19427.1, CCDS39149.1
International Mouse Knockout Project StatusG3bp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23881 NCBI Gene Model | MGI Sequence Detail 31590 C57BL/6J ±  kb
transcript NM_001080794 RefSeq | MGI Sequence Detail 4331 C57BL/6 
polypeptide P97379 UniProt | EBI | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(14) UniProt(7)
Polymorphisms SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002075 Nuclear transport factor 2
InterPro IPR018222 Nuclear transport factor 2, Eukaryote
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000007744 ras GTPase-activating protein-binding protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:57569 Kennedy D, et al., Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. Biomed Pept Proteins Nucleic Acids. 1996-97;2(3):93-9
(Latest) J:201630 Ryder E, et al., Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome. 2013 Aug;24(7-8):286-94
All references(41)
Other
accession IDs
MGI:1346339, MGI:2146760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory