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G3bp2
Gene Detail
Symbol

Name
ID
G3bp2
GTPase activating protein (SH3 domain) binding protein 2
MGI:2442040
Synonyms
E430034L04Rik, G3BP, G3BP2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
45.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:92052164-92083719 bp, - strand
From VEGA annotation of GRCm38

  31556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137244  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: G3BP2
Gene Tree: G3bp2

Human
homologs
G3BP2, GTPase activating protein (SH3 domain) binding protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9908
neXtProt AC: NX_Q9UN86

Human Chr (Location): 4q21.1; chr4:75642769-75724525 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(234) : Gene trapped(232) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
G3bp2 interacts with 437 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process mRNA transport, small GTPase mediated signal transduction, ...
Component cytoplasm, intracellular
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (23)    Tissues (23)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
RT-PCR 2
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase g3bp2    NEW 
Molecular
reagents
All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000055584 (Evidence)
Ensembl Gene Model ENSMUSG00000029405 (Evidence)
Entrez Gene 23881 (Evidence)
DFCI TC1573288, TC1584448, TC1603716, TC1632949, TC1664723, TC1675054
DoTS DT.101149021, DT.101283057, DT.101398213, DT.101704781, DT.103577956, DT.110681713, DT.55162818, DT.55201207, DT.94400190, DT.94400480, DT.97401142
NIA Mouse Gene Index U026400, U145146
Consensus CDS Project CCDS19427.1, CCDS39149.1
International Mouse Phenotyping Consortium Status G3bp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055584 VEGA Gene Model | MGI Sequence Detail 31556 C57BL/6J ±  kb
transcript OTTMUST00000137561 VEGA | MGI Sequence Detail 3026 Not Applicable 
polypeptide OTTMUSP00000072426 VEGA | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002075 Nuclear transport factor 2
InterPro IPR018222 Nuclear transport factor 2, eukaryote
InterPro IPR012677 Nucleotide-binding alpha-beta plait domain
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000007744 ras GTPase-activating protein-binding protein 2
References
(Earliest) J:57569 Kennedy D, et al., Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. Biomed Pept Proteins Nucleic Acids. 1996-97;2(3):93-9
(Latest) J:201630 Ryder E, et al., Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome. 2013 Aug;24(7-8):286-94
All references(42)
Other
accession IDs
MGI:1346339, MGI:2146760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory