G3bp2
Gene Detail

Symbol Name ID

G3bp2 GTPase activating protein (SH3 domain) binding protein 2 MGI:2442040

Synonyms

E430034L04Rik, G3BP, G3BP2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

45.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:92052146-92083735 bp, - strand From NCBI annotation of GRCm38   31590 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40792  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: G3bp2

Human homologs

Human Homolog		G3BP2, GTPase activating protein (SH3 domain) binding protein 2
NCBI Gene ID		9908
neXtProt AC		NX_Q9UN86
Human Chr (Location)		4q21.1; chr4:76567953-76598667 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(234) : Targeted(2) Gene trapped(232)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	mRNA transport, small GTPase mediated signal transduction, ...
Component	cytoplasm, intracellular
Function	nucleic acid binding, nucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (23)    Tissues (23)    Images (3)
Theiler Stages: 21, 28

Assay Type	Results
RNA in situ	21
RT-PCR	2

cDNA source data(536)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(538) cDNA(537) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000029405 (Evidence)
Entrez Gene	23881 (Evidence)
UniGene	290530
DFCI	TC1573288, TC1584448, TC1603716, TC1632949, TC1664723, TC1675054
DoTS	DT.101149021, DT.101398213, DT.101704781, DT.103577956, DT.110681713, DT.55162818, DT.55201207, DT.94400190, DT.94400480, DT.97401142
NIA Mouse Gene Index	U026400, U145146
Consensus CDS Project	CCDS19427.1, CCDS39149.1
International Mouse Knockout Project Status	G3bp2

Sequences

Length	Strain/Species
genomic	23881	NCBI Gene Model | MGI Sequence Detail	31590	C57BL/6J
transcript	NM_001080794	RefSeq | MGI Sequence Detail	4331	C57BL/6
polypeptide	P97379	UniProt | EBI | MGI Sequence Detail	482	Not Applicable

All sequences(85) RefSeq(10) UniProt(7)

Polymorphisms

SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002075	Nuclear transport factor 2
InterPro	IPR018222	Nuclear transport factor 2, Eukaryote
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000007744	ras GTPase-activating protein-binding protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:57569 Kennedy D, et al., Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. Biomed Pept Proteins Nucleic Acids. 1996-97;2(3):93-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Other accession IDs

MGI:1346339, MGI:2146760