About   Help   FAQ
Daglb
Gene Detail
 Symbol
Name
ID
Daglb
diacylglycerol lipase, beta
MGI:2442032
Synonyms E330036I19Rik
Feature Type protein coding gene
Genetic Map
Chromosome 5
82.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:143472947-143504442 bp, + strand
From VEGA annotation of GRCm38

  31496 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:34715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Daglb

Human
homologs
Human Homolog DAGLB, diacylglycerol lipase, beta
NCBI Gene ID 221955
neXtProt AC  NX_Q8NCG7
Human Synonyms  DAGLBETA, KCCR13L
Human Chr (Location)  7p22.1; chr7:6409116-6448012 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations have a reduction in endocannabinoids in the brain and a decrease in adult neuronal proliferation in the hippocampus.
 
Interactions
Daglb interacts with 174 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process arachidonic acid metabolic process, lipid catabolic process, ...
Component bounding membrane of organelle, integral component of membrane, ...
Function 1-oxa-2-oxocycloheptane lactonase activity, 3,4-dihydrocoumarin hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (61)    Tissues (8)    Images (22)
Theiler Stages: 1, 2, 3, 5, 23, 28
Assay TypeResults
RNA in situ 51
RT-PCR 10
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021320 (Evidence)
Ensembl Gene ModelENSMUSG00000039206 (Evidence)
Entrez Gene231871 (Evidence)
EC3.1.1.-
Consensus CDS ProjectCCDS39370.1
International Mouse Knockout Project StatusDaglb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021320 VEGA Gene Model | MGI Sequence Detail 31496 C57BL/6J ±  kb
transcript OTTMUST00000050543 VEGA | MGI Sequence Detail 2806 Not Applicable 
polypeptide OTTMUSP00000023608 VEGA | MGI Sequence Detail 587 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(315 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002921 Lipase, class 3
Protein Ontology PR:000006269 sn1-specific diacylglycerol lipase beta
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:189393 Yoshino H, et al., Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. J Physiol. 2011 Oct 15;589(Pt 20):4857-84
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory