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Rapgef3 Gene Detail
Summary
  • Symbol
    Rapgef3
  • Name
    Rap guanine nucleotide exchange factor (GEF) 3
  • Synonyms
    2310016P22Rik, 9330170P05Rik, Epac1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441741
    NCBI Gene: 223864
  • Gene Overview
    MyGene.info: RAPGEF3
Location & Maps
more
  • Sequence Map
    Chr15:97744770-97767972 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23203 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 53.74 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RAPGEF3, Rap guanine nucleotide exchange factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAPGEF3, Rap guanine nucleotide exchange factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bcm910, CAMP-GEFI, EPAC, EPAC1, HSU79275
  • Links
    NCBI Gene ID: 10411
    neXtProt AC: NX_O95398

  • Chr Location
    12q13.11; chr12:47734670-47771035 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 6 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    8
  • Genomic Mutations
    3 involving Rapgef3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased induced neuron apoptosis. Mice homozygous for a different allele exhibit impaired glucose homeostasis with decreased insulin secretion, increased susceptibility to diet-induced obesity and streptozotocin-induced insulitis and hyperglycemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032758 VEGA Gene Model | MGI Sequence Detail 23203 C57BL/6J ±  kb
transcript OTTMUST00000081544 VEGA | MGI Sequence Detail 4005 Not Applicable  
polypeptide OTTMUSP00000043645 VEGA | MGI Sequence Detail 926 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    186 from dbSNP Build 142
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000013728 rap guanine nucleotide exchange factor 3
  • InterPro Domains
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR000591 DEP domain
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    IPR014710 RmlC-like jelly roll fold
    IPR029071 Ubiquitin-related domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
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MGI:1917354
References
more
  • Summaries
    All 54
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 6
    Phenotypes 36
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:235384 Cai W, et al., Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction. Biochem Biophys Res Commun. 2016 Jun 17;475(1):1-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory