About   Help   FAQ
Rapgef3
Gene Detail
Symbol

Name
ID
Rapgef3
Rap guanine nucleotide exchange factor (GEF) 3
MGI:2441741
Synonyms
2310016P22Rik, 9330170P05Rik, Epac1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
53.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:97744770-97767972 bp, - strand
From VEGA annotation of GRCm38

  23203 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rapgef3

Human
homologs
Human Homolog RAPGEF3, Rap guanine nucleotide exchange factor (GEF) 3
NCBI Gene ID 10411
neXtProt AC  NX_O95398
Human Synonyms  bcm910, CAMP-GEFI, EPAC, EPAC1, HSU79275
Human Chr (Location)  12q13.1; chr12:47734670-47759106 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(1) Targeted(7)
Genomic Mutations involving Rapgef3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased induced neuron apoptosis. Mice homozygous for a different allele exhibit impaired glucose homeostasis with decreased insulin secretion, increased susceptibility to diet-induced obesity and streptozotocin-induced insulitis and hyperglycemia.
 
Interactions
Rapgef3 interacts with 312 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process angiogenesis, cellular response to cAMP, ...
Component cAMP-dependent protein kinase complex, cytoplasm, ...
Function cAMP binding, cAMP-dependent protein kinase regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (33)    Tissues (15)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
RT-PCR 20
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000032758 (Evidence)
Ensembl Gene ModelENSMUSG00000022469 (Evidence)
Entrez Gene223864 (Evidence)
DFCITC1777969, TC1757696, TC1598741, TC1683463, TC1603340, TC1578683
DoTSDT.101386170, DT.110833093, DT.40152023, DT.97371583
NIA Mouse Gene IndexU036605, U016614
Consensus CDS ProjectCCDS37187.2, CCDS49713.1, CCDS49714.1
International Mouse Knockout Project StatusRapgef3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032758 VEGA Gene Model | MGI Sequence Detail 23203 C57BL/6J ±  kb
transcript OTTMUST00000081544 VEGA | MGI Sequence Detail 4005 Not Applicable 
polypeptide OTTMUSP00000043645 VEGA | MGI Sequence Detail 926 Not Applicable 

For the selected sequences
All sequences(127) RefSeq(18) UniProt(23)
Polymorphisms
SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002373 cAMP/cGMP-dependent protein kinase
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR000591 DEP domain
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR019804 Ras guanine-nucleotide exchange factor, conserved site
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
InterPro IPR014710 RmlC-like jelly roll fold
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013728 rap guanine nucleotide exchange factor 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210778 Herfindal L, et al., Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochem Biophys Res Commun. 2013 Aug 9;437(4):603-8
All references(43)
Other
accession IDs
MGI:1917354

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory