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Rapgef3 Gene Detail
Summary
  • Symbol
    Rapgef3
  • Name
    Rap guanine nucleotide exchange factor (GEF) 3
  • Synonyms
    2310016P22Rik, 9330170P05Rik, Epac1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441741
    NCBI Gene: 223864
  • Gene Overview
    MyGene.info: RAPGEF3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:97744770-97767972 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23203 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 53.74 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RAPGEF3, Rap guanine nucleotide exchange factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAPGEF3, Rap guanine nucleotide exchange factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bcm910, CAMP-GEFI, EPAC, EPAC1, HSU79275
  • Links
    NCBI Gene ID: 10411
    neXtProt AC: NX_O95398
    UniProt: O95398

  • Chr Location
    12q13.11; chr12:47734670-47759106 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 6 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased induced neuron apoptosis. Mice homozygous for a different allele exhibit impaired glucose homeostasis with decreased insulin secretion, increased susceptibility to diet-induced obesity and streptozotocin-induced insulitis and hyperglycemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032758 VEGA Gene Model | MGI Sequence Detail 23203 C57BL/6J ±  kb
    transcript OTTMUST00000081544 VEGA | MGI Sequence Detail 4005 Not Applicable  
    polypeptide OTTMUSP00000043645 VEGA | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      186 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000013728 rap guanine nucleotide exchange factor 3
    • InterPro Domains
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding-like
      IPR000591 DEP domain
      IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
      IPR019804 Ras guanine-nucleotide exchange factor, conserved site
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
      IPR014710 RmlC-like jelly roll fold
      IPR029071 Ubiquitin-like domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917354
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 40
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:262014 Fazal L, et al., Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death. Circ Res. 2017 Feb 17;120(4):645-657

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory