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Ffar2 Gene Detail
Summary
  • Symbol
    Ffar2
  • Name
    free fatty acid receptor 2
  • Synonyms
    Gpr43
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441731
    NCBI Gene: 233079
  • Gene Overview
    MyGene.info: FFAR2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:30818348-30823775 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 19.25 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FFAR2, free fatty acid receptor 2
  • Vertebrate Orthologs
    36
  • Human Ortholog
    FFAR2, free fatty acid receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FFA2R, GPR43
  • Links
    NCBI Gene ID: 2867
    neXtProt AC: NX_O15552
    UniProt: O15552

  • Chr Location
    19q13.12; chr19:35447965-35451767 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered granulocyte and neutrophil physiology and increased inflammation in models of induced colitis, arthritis and asthma, whereas homozygotes for a different null allele show reduced neutrophil recruitment and decreased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000049767 VEGA Gene Model | MGI Sequence Detail 5428 C57BL/6J ±  kb
    transcript OTTMUST00000126759 VEGA | MGI Sequence Detail 2301 Not Applicable  
    polypeptide OTTMUSP00000068524 VEGA | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      98 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:259394 Marino E, et al., Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol. 2017 May;18(5):552-562

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/03/2018
    MGI 6.12
    The Jackson Laboratory