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Ffar2
Gene Detail
 Symbol
Name
ID
Ffar2
free fatty acid receptor 2
MGI:2441731
Synonyms Gpr43
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:30818357-30823775 bp, - strand
From NCBI annotation of GRCm38

  5419 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133911  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 24 chicken; 4 zebrafish

Protein SuperFamily: free fatty acid receptor
Gene Tree: Ffar2

Human
homologs
Human Homolog FFAR2, free fatty acid receptor 2
NCBI Gene ID 2867
neXtProt AC  NX_O15552
Human Synonyms  FFA2R, GPR43
Human Chr (Location)  19q13.1; chr19:35449715-35451767 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for a one null allele exhibit increased susceptibility to induced colitis, arthritis, and asthma, whereas mice homozygous for another exhibit decreased susceptibility to induced colitis, increased sensitivity to xenobiotic induced mortality, and abnormal neutrophils.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular response to fatty acid, glucose homeostasis, ...
Component cell projection, integral component of membrane, ...
Function G-protein coupled receptor activity, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (15)    Tissues (3)    Images (15)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 13
RT-PCR 2
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000051314 (Evidence)
Entrez Gene233079 (Evidence)
UniGene97338
DFCITC1584889, TC1610228, TC1675319, TC1676923
DoTSDT.101362967, DT.111018701, DT.40158039, DT.55196628, DT.55247144, DT.87072230, DT.94226971
NIA Mouse Gene IndexU028400
Consensus CDS ProjectCCDS21111.1
International Mouse Knockout Project StatusFfar2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 233079 NCBI Gene Model | MGI Sequence Detail 5419 C57BL/6J ±  kb
transcript NM_146187 RefSeq | MGI Sequence Detail 2292 C57BL/6 
polypeptide Q8VCK6 UniProt | EBI | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(10) UniProt(1)
Polymorphisms SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR013312 G protein-coupled receptor 40-related receptor
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001583 free fatty acid receptor 2
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:197123 Hudson BD, et al., Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. J Biol Chem. 2012 Nov 30;287(49):41195-209
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory