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Ffar2
Gene Detail
Symbol

Name
ID
Ffar2
free fatty acid receptor 2
MGI:2441731
Synonyms
Gpr43
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:30818348-30823775 bp, - strand
From VEGA annotation of GRCm38

  5428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133911  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 24 chicken; 1 western clawed frog; 4 zebrafish

Protein SuperFamily: free fatty acid receptor
Gene Tree: Ffar2

Human
homologs
Human Homolog FFAR2, free fatty acid receptor 2
NCBI Gene ID 2867
neXtProt AC  NX_O15552
Human Synonyms  FFA2R, GPR43
Human Chr (Location)  19q13.1; chr19:35449715-35451767 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for a one null allele exhibit increased susceptibility to induced colitis, arthritis, and asthma, whereas mice homozygous for another exhibit decreased susceptibility to induced colitis, increased sensitivity to xenobiotic induced mortality, and abnormal neutrophils.
 
Interactions
Ffar2 interacts with 76 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (15)    Tissues (3)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
RT-PCR 2
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000049767 (Evidence)
Ensembl Gene ModelENSMUSG00000051314 (Evidence)
Entrez Gene233079 (Evidence)
UniGene97338
DFCITC1584889, TC1610228, TC1675319, TC1676923
DoTSDT.101362967, DT.111018701, DT.40158039, DT.55196628, DT.55247144, DT.87072230, DT.94226971
NIA Mouse Gene IndexU028400
Consensus CDS ProjectCCDS21111.1
International Mouse Knockout Project StatusFfar2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049767 VEGA Gene Model | MGI Sequence Detail 5428 C57BL/6J ±  kb
transcript OTTMUST00000126759 VEGA | MGI Sequence Detail 2301 Not Applicable 
polypeptide OTTMUSP00000068524 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR013312 G protein-coupled receptor 40-related receptor
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001583 free fatty acid receptor 2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:211434 Kim MH, et al., Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology. 2013 Aug;145(2):396-406.e1-10
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory