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Maml3 Gene Detail
Summary
  • Symbol
    Maml3
  • Name
    mastermind like 3 (Drosophila)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389461
    NCBI Gene: 433586
  • Gene Overview
    MyGene.info: MAML3
Location & Maps
more
  • Sequence Map
    Chr3:51685907-52105076 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      419170 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 22.54 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAML3, mastermind like transcriptional coactivator 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAML3, mastermind like transcriptional coactivator 3
    Orthology source: HomoloGene
  • Synonyms
    CAGH3, ERDA3, GDN, MAM2, MAM-2, TNRC3
  • Links
    NCBI Gene ID: 55534
    neXtProt AC: NX_Q96JK9

  • Chr Location
    4q28; chr4:139716391-140154079 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41284
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MAML3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    4
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Maml3
  • Incidental Mutations
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026673 VEGA Gene Model | MGI Sequence Detail 419170 C57BL/6J ±  kb
transcript OTTMUST00000066001 VEGA | MGI Sequence Detail 8288 Not Applicable  
polypeptide OTTMUSP00000032980 VEGA | MGI Sequence Detail 1135 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2473 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR019082 Neurogenic mastermind-like, N-terminal
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Other 1

    Microarray probesets 1
Other
Accession IDs
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MGI:2139941, MGI:3055089
References
more
  • Summaries
    All 28
    Developmental Gene Expression 9
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:79612 Wu L, et al., Identification of a family of mastermind-like transcriptional coactivators for Mammalian notch receptors. Mol Cell Biol. 2002 Nov;22(21):7688-700
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory