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Maml3 Gene Detail
Summary
  • Symbol
    Maml3
  • Name
    mastermind like transcriptional coactivator 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389461
    NCBI Gene: 433586
  • Gene Overview
    MyGene.info: MAML3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:51687320-52105086 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 22.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2453 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389461
protein coding gene Chr3:51685907-52105086 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027201
protein coding gene Chr3:50169490-50611784 (-)
A/J MGP_AJ_G0027161
protein coding gene Chr3:48701981-49129025 (-)
AKR/J MGP_AKRJ_G0027130
protein coding gene Chr3:49669526-50097904 (-)
BALB/cJ MGP_BALBcJ_G0027173
protein coding gene Chr3:48561853-48982233 (-)
C3H/HeJ MGP_C3HHeJ_G0026916
protein coding gene Chr3:49897840-50328122 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027619
protein coding gene Chr3:52191569-52632953 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024979
protein coding gene Chr3:45329552-45746779 (-)
CAST/EiJ MGP_CASTEiJ_G0026369
protein coding gene Chr3:49962660-50403727 (-)
CBA/J MGP_CBAJ_G0026893
protein coding gene Chr3:53812209-54281174 (-)
DBA/2J MGP_DBA2J_G0027027
protein coding gene Chr3:48306567-48725871 (-)
FVB/NJ MGP_FVBNJ_G0026995
protein coding gene Chr3:47288245-47708186 (-)
LP/J MGP_LPJ_G0027139
protein coding gene Chr3:50925703-51367953 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027013
protein coding gene Chr3:57994695-58440231 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027678
protein coding gene Chr3:49596560-50029486 (-)
PWK/PhJ MGP_PWKPhJ_G0026101
protein coding gene Chr3:47959631-48389043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025914
protein coding gene Chr3:49251921-49670766 (-)
WSB/EiJ MGP_WSBEiJ_G0026443
protein coding gene Chr3:49703361-50131797 (-)



Homology
more
  • Human Ortholog
    MAML3, mastermind like transcriptional coactivator 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAML3, mastermind like transcriptional coactivator 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAGH3, ERDA3, GDN, MAM2, MAM-2, mam-3, TNRC3
  • Links
    NCBI Gene ID: 55534
    neXtProt AC: NX_Q96JK9
    UniProt: Q96JK9

  • Chr Location
    4q31.1; chr4:139716391-140154079 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41284
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MAML3
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    9 phenotype references
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 433586 NCBI Gene Model | MGI Sequence Detail 417767 C57BL/6J ±  kb
transcript NM_001004176 RefSeq | MGI Sequence Detail 6514 Not Specified  
polypeptide NP_001004176 RefSeq | MGI Sequence Detail 1135 Not Specified  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR019082 Neurogenic mastermind-like, N-terminal
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:2139941, MGI:3055089
References
more
  • Summaries
    All 35
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory