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Hydin Gene Detail
Summary
  • Symbol
    Hydin
  • Name
    HYDIN, axonemal central pair apparatus protein
  • Synonyms
    1700034M11Rik, 4930545D19Rik, hy3, hy-3, hyrh
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389007
    NCBI Gene: 244653
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110266977-110610253 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.50 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389007
protein coding gene Chr8:110266977-110610253 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034124
protein coding gene Chr8:112925330-113288225 (+)
A/J MGP_AJ_G0034103
protein coding gene Chr8:108340189-108695308 (+)
AKR/J MGP_AKRJ_G0034030
protein coding gene Chr8:111532310-111887322 (+)
BALB/cJ MGP_BALBcJ_G0034097
protein coding gene Chr8:108541002-108890067 (+)
C3H/HeJ MGP_C3HHeJ_G0033808
protein coding gene Chr8:112232143-112600211 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034617
protein coding gene Chr8:116910502-117283252 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031559
protein coding gene Chr8:101361198-101700707 (+)
CAST/EiJ MGP_CASTEiJ_G0033135
protein coding gene Chr8:111846590-112209469 (+)
CBA/J MGP_CBAJ_G0033782
protein coding gene Chr8:120845479-121248144 (+)
DBA/2J MGP_DBA2J_G0033937
protein coding gene Chr8:107656145-108003982 (+)
FVB/NJ MGP_FVBNJ_G0033881
protein coding gene Chr8:106606078-106959427 (+)
LP/J MGP_LPJ_G0034027
protein coding gene Chr8:113108824-113478989 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033927
protein coding gene Chr8:123825728-124185185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034636
protein coding gene Chr8:111487727-111853993 (+)
PWK/PhJ MGP_PWKPhJ_G0032838
protein coding gene Chr8:107227359-107581004 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032677
protein coding gene Chr8:110171769-110539496 (+)
WSB/EiJ MGP_WSBEiJ_G0033251
protein coding gene Chr8:112168234-112542068 (+)



Homology
more
  • Human Ortholog
    HYDIN, HYDIN axonemal central pair apparatus protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HYDIN, HYDIN axonemal central pair apparatus protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD5, HYDIN1, HYDIN2, PPP1R31
  • Links
    NCBI Gene ID: 54768
    neXtProt AC: NX_Q4G0P3
    UniProt: Q4G0P3

  • Chr Location
    16q22.2; chr16:70802084-71230722 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 52118
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HYDIN
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Hydin mouse models; 1 with human HYDIN associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 3 alleles in 4 genetic backgrounds
    7 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation in this gene develop hydrocephaly after birth. Symptoms develop after 3-5 days. Affected animals usually die before 2 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244653 NCBI Gene Model | MGI Sequence Detail 343277 C57BL/6J ±  kb
    transcript NM_172916 RefSeq | MGI Sequence Detail 15783 Not Specified  
    polypeptide Q80W93 UniProt | EBI | MGI Sequence Detail 5154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 3
      cDNA 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11026, MGD-MRK-11029, MGI:1922491, MGI:1923961, MGI:2157966, MGI:3801607, MGI:96295
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:13035 Gruneberg H, Two new mutant genes in the house mouse. J Genet. 1943;45:22-28
    • Latest
      J:267879 Mahuzier A, et al., Ependymal cilia beating induces an actin network to protect centrioles against shear stress. Nat Commun. 2018 Jun 11;9(1):2279

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory