Tg(tetO-Vegfa)1Kesh
Transgene Detail

Summary

• Symbol: Tg(tetO-Vegfa)1Kesh
• Name: transgene insertion 1, Eli Keshet
• MGI ID: MGI:2388011
• Synonyms: pTET-VEGF, tet(0)-sflt-1, TET-VEGF165
• Transgene: Tg(tetO-Vegfa)1Kesh Location: unknown
• Alliance: Tg(tetO-Vegfa)1Kesh page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Vegfa)1Kesh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Vegfa (MGI:103178)	expresses the soluble form of the protein

• Mutation details: The full-length mouse Vegfa cDNA fused to a tetracycline-responsive cytomegalovirus promoter was used as the transgene. (J:68214)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-Vegfa)1Kesh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

The glioma cell line C6 was used for transgene injection. The construct was originally described in Benjamin and Keshet, 1997, PNAS 94, 8761-8766.

References

• Original: J:68214 Dor Y, et al., A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development. 2001 May;128(9):1531-8
• All: 10 reference(s)