Tg(PMP22)C22Clh
Transgene Detail
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Symbol: |
Tg(PMP22)C22Clh |
Name: |
transgene insertion C22, Clare Huxley |
MGI ID: |
MGI:2183770 |
Synonyms: |
C22 |
Transgene: |
Tg(PMP22)C22Clh Location: unknown Genetic Position: Chr8, Syntenic
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Alliance: |
Tg(PMP22)C22Clh page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(PMP22)C22Clh expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
PMP22 (5376) |
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Mutation details: A YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was largely intact including the region containing PMP22. Founder C22 carries 8 copies of the human transgene on chromosome 8 with an expression pattern similar to that of the endogenous mouse gene. The expression level of each human transgene is approximately 0.4X that of one mouse gene.
(J:78221)
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Inheritance: |
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Dominant |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:78221 Huxley C, et al., Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA. Hum Mol Genet. 1996 May;5(5):563-9 |
All: |
16 reference(s) |
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