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Wac Gene Detail
Summary
  • Symbol
    Wac
  • Name
    WW domain containing adaptor with coiled-coil
  • Synonyms
    1110067P07Rik, A230035H12Rik, Wwp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387357
    NCBI Gene: 225131
Location & Maps
more
  • Sequence Map
    Chr18:7868832-7973547 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      104716 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    WAC, WW domain containing adaptor with coiled-coil
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WAC, WW domain containing adaptor with coiled-coil
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BM-016, PRO1741, Wwp4
  • Links
    NCBI Gene ID: 51322
    neXtProt AC: NX_Q9BTA9

  • Chr Location
    10p12.1-p11.2; chr10:28532588-28623112 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41148
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: WAC
  • Gene Tree
    Wac
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    55
  • Gene trapped
    51
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036803 VEGA Gene Model | MGI Sequence Detail 104716 C57BL/6J ±  kb
transcript OTTMUST00000094454 VEGA | MGI Sequence Detail 5208 Not Applicable  
polypeptide OTTMUSP00000052531 VEGA | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    550 from dbSNP Build 137
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000031681 WW domain-containing adapter protein with coiled-coil
  • InterPro Domains
    IPR001202 WW domain
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 5
Other
Accession IDs
less
MGI:1923581, MGI:2147203, MGI:2147204
References
more
  • Summaries
    All 38
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:175602 Totsukawa G, et al., VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion. EMBO J. 2011;30(17):3581-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory