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Wac
Gene Detail
Symbol

Name
ID
Wac
WW domain containing adaptor with coiled-coil
MGI:2387357
Synonyms
1110067P07Rik, A230035H12Rik, Wwp4
Feature Type
protein coding gene
Genetic Map
Chromosome 18
4.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:7868832-7973547 bp, + strand
From VEGA annotation of GRCm38

  104716 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WAC
Gene Tree: Wac

Human
homologs
WAC, WW domain containing adaptor with coiled-coil
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51322
neXtProt AC: NX_Q9BTA9

Human Synonyms: BM-016, PRO1741, Wwp4

Human Chr (Location): 10p12.1-p11.2; chr10:28532588-28623112 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(54) : Gene trapped(51) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Wac interacts with 398 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component nucleoplasm, nucleus, ...
Function chromatin binding, RNA polymerase II core binding
External Resources: FuncBase
Expression
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wac ; ZFIN waca    NEW 
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036803 (Evidence)
Ensembl Gene Model ENSMUSG00000024283 (Evidence)
Entrez Gene 225131 (Evidence)
DFCI TC1611328, TC1600993, TC1727274, TC1574738, TC1666677, TC1629496
Consensus CDS Project CCDS29046.1, CCDS50218.1, CCDS70869.1
International Mouse Phenotyping Consortium Status Wac
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036803 VEGA Gene Model | MGI Sequence Detail 104716 C57BL/6J ±  kb
transcript OTTMUST00000094454 VEGA | MGI Sequence Detail 5208 Not Applicable 
polypeptide OTTMUSP00000052531 VEGA | MGI Sequence Detail 646 Not Applicable 

For the selected sequences
All sequences(139) RefSeq(20) UniProt(12)
Polymorphisms
SNPs within 2kb(550 from dbSNP Build 137)    SNPs within 2kb including multiple locations(554)
Protein-related
information
ResourceIDDescription
InterPro IPR001202 WW domain
Protein Ontology PR:000031681 WW domain-containing adapter protein with coiled-coil
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:175602 Totsukawa G, et al., VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion. EMBO J. 2011;30(17):3581-93
All references(38)
Other
accession IDs
MGI:1923581, MGI:2147203, MGI:2147204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory