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Lnpep Gene Detail
Summary
  • Symbol
    Lnpep
  • Name
    leucyl/cystinyl aminopeptidase
  • Synonyms
    2010309L07Rik, 4732490P18Rik, gp160, IRAP, vp165
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387123
    NCBI Gene: 240028
  • Gene Overview
    MyGene.info: LNPEP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:17527723-17624489 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96767 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 9.77 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LNPEP, leucyl and cystinyl aminopeptidase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LNPEP, leucyl and cystinyl aminopeptidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP, IRAP, PLAP, P-LAP
  • Links
    NCBI Gene ID: 4012
    neXtProt AC: NX_Q9UIQ6
    UniProt: Q9UIQ6

  • Chr Location
    5q15; chr5:96935642-97029411 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21148
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LNPEP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a somewhat reduced tissue uptake of glucose either basally or after insulin stimulation. Mice homozygous for a different knock-out allele exhibit impaired coordination at 3 months and impaired spatial working memory in a Y maze at 6 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 240028 NCBI Gene Model | MGI Sequence Detail 96767 C57BL/6J ±  kb
transcript NM_172827 RefSeq | MGI Sequence Detail 5181 C57BL/6  
polypeptide Q8C129 UniProt | EBI | MGI Sequence Detail 1025 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    591 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
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MGI:1913735, MGI:2443260
References
more
  • Summaries
    All 52
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:68323 Carninci P, et al., Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 2000 Oct;10(10):1617-30
  • Latest
    J:260126 Babdor J, et al., IRAP(+) endosomes restrict TLR9 activation and signaling. Nat Immunol. 2017 May;18(5):509-518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory