Lnpep Gene Detail

Summary

• Symbol
  Lnpep
• Name
  leucyl/cystinyl aminopeptidase
• Synonyms
  2010309L07Rik, 4732490P18Rik, gp160, IRAP, vp165

• Feature Type
  protein coding gene
• IDs
  MGI:2387123
  NCBI Gene: 240028
• Gene Overview
  MyGene.info: LNPEP
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr17:17527723-17624489 bp, - strand
• From NCBI annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    96767 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 9.77 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  LNPEP, leucyl and cystinyl aminopeptidase

• Vertebrate Orthologs
  9

• Human Ortholog
  LNPEP, leucyl and cystinyl aminopeptidase
  Orthology source: HomoloGene, HGNC
• Synonyms
  CAP, IRAP, PLAP, P-LAP
• Links
  HGNC:6656

  NCBI Gene ID: 4012

  neXtProt AC: NX_Q9UIQ6

  UniProt: Q9UIQ6

  
  
• Chr Location
  5q15; chr5:96935642-97029411 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 21148
  1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: LNPEP
• Gene Tree
  Lnpep
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  20 phenotypes from 2 alleles in 3 genetic backgrounds
  20 phenotype references
  

• All Mutations and Alleles
  72
• Gene trapped
  66
• Targeted
  6
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  45 strains or lines available

Mice homozygous for a knock-out allele exhibit a somewhat reduced tissue uptake of glucose either basally or after insulin stimulation. Mice homozygous for a different knock-out allele exhibit impaired coordination at 3 months and impaired spatial working memory in a Y maze at 6 months of age.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  23
• GO References
  9

• External Resources
  FuncBase

Expression

• cDNA Data
  15

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase lnpep

Interactions

• Lnpep interacts with 296 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  2
• UniProt
  5
• CCDS
  CCDS37457.1

• Ensembl
  ENSMUSG00000023845 (Evidence)
• NCBI Gene
  240028

Representative Sequences			Length	Strain/Species
genomic	240028	NCBI Gene Model | MGI Sequence Detail	96767	C57BL/6J
transcript	NM_172827	RefSeq | MGI Sequence Detail	5181	C57BL/6
polypeptide	Q8C129	UniProt | EBI | MGI Sequence Detail	1025	Not Applicable

Polymorphisms

• SNPs within 2kb
  591 from dbSNP Build 142

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000009874 leucyl-cystinyl aminopeptidase
  (term hierarchy)
• EC
  3.4.11.-, 3.4.11.3
• InterPro Domains
  IPR034016 Aminopeptidase N-type
  IPR034017 Cystinyl aminopeptidase
  IPR024571 ERAP1-like C-terminal domain
  IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
  IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal

Molecular
Reagents

• All nucleic 15

  cDNA 15

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1913735, MGI:2443260

References

• Summaries
  All 52

  Gene Ontology 9

  Phenotypes 20
• Earliest
  J:68323 Carninci P, et al., Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 2000 Oct;10(10):1617-30
• Latest
  J:260126 Babdor J, et al., IRAP(+) endosomes restrict TLR9 activation and signaling. Nat Immunol. 2017 May;18(5):509-518