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Sirt7 Gene Detail
Summary
  • Symbol
    Sirt7
  • Name
    sirtuin 7
  • Synonyms
    MGC:31235, MGC:37560
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385849
    NCBI Gene: 209011
  • Gene Overview
    MyGene.info: SIRT7
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120618372-120625008 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385849
protein coding gene Chr11:120618372-120625240 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019516
protein coding gene Chr11:125098429-125105298 (-)
A/J MGP_AJ_G0019484
protein coding gene Chr11:119528452-119535321 (-)
AKR/J MGP_AKRJ_G0019454
protein coding gene Chr11:123135491-123142360 (-)
BALB/cJ MGP_BALBcJ_G0019459
protein coding gene Chr11:119885755-119892624 (-)
C3H/HeJ MGP_C3HHeJ_G0019265
protein coding gene Chr11:123459116-123465985 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019907
protein coding gene Chr11:128882235-128889104 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017533
protein coding gene Chr11:116517796-116524581 (-)
CAST/EiJ MGP_CASTEiJ_G0018819
protein coding gene Chr11:124961333-124968215 (-)
CBA/J MGP_CBAJ_G0019236
protein coding gene Chr11:133917984-133924775 (-)
DBA/2J MGP_DBA2J_G0019348
protein coding gene Chr11:118896793-118903662 (-)
FVB/NJ MGP_FVBNJ_G0019340
protein coding gene Chr11:118608814-118616398 (-)
LP/J MGP_LPJ_G0019420
protein coding gene Chr11:125398041-125407235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019373
protein coding gene Chr11:132753816-132762665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019947
protein coding gene Chr11:123811669-123818538 (-)
PWK/PhJ MGP_PWKPhJ_G0018585
protein coding gene Chr11:120335174-120342028 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018377
protein coding gene Chr11:123576405-123585402 (-)
WSB/EiJ MGP_WSBEiJ_G0018871
protein coding gene Chr11:123801644-123808509 (-)



Homology
more
  • Human Ortholog
    SIRT7, sirtuin 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIRT7, sirtuin 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SIR2L7
  • Links
    NCBI Gene ID: 51547
    neXtProt AC: NX_Q9NRC8
    UniProt: Q9NRC8

  • Chr Location
    17q25.3; chr17:81911939-81918182 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56152
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIRT7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit premature aging and death associated with inflammatory, degenerative cardiac hypertrophy and cardiac fibrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209011 NCBI Gene Model | MGI Sequence Detail 6637 C57BL/6J ±  kb
    transcript NM_001363439 RefSeq | MGI Sequence Detail 1870 C57BL/6  
    polypeptide Q8BKJ9 UniProt | EBI | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:263020 Miyasato Y, et al., Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response. Sci Rep. 2018 Apr 12;8(1):5927

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory