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Sirt7
Gene Detail
Symbol

Name
ID
Sirt7
sirtuin 7
MGI:2385849
Synonyms
MGC:31235, MGC:37560
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:120618372-120625240 bp, - strand
From VEGA annotation of GRCm38

  6869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56152  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sirt7

Human
homologs
Human Homolog SIRT7, sirtuin 7
NCBI Gene ID 51547
neXtProt AC  NX_Q9NRC8
Human Synonyms  SIR2L7
Human Chr (Location)  17q25; chr17:81911939-81918182 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit premature aging and death associated with inflammatory, degenerative cardiac hypertrophy and cardiac fibrosis.
 
Interactions
Sirt7 interacts with 127 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (71)    Tissues (52)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
Northern blot 12
Western blot 16
RT-PCR 10
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000004085 (Evidence)
Ensembl Gene ModelENSMUSG00000025138 (Evidence)
Entrez Gene209011 (Evidence)
DFCITC1604151, TC1593175, TC1576629, TC1624391
DoTSDT.101336527, DT.101224074, DT.530916, DT.110514239, DT.101372417, DT.97368892
EC3.5.1.-
Consensus CDS ProjectCCDS49006.1
International Mouse Knockout Project StatusSirt7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004085 VEGA Gene Model | MGI Sequence Detail 6869 C57BL/6J ±  kb
transcript OTTMUST00000009176 VEGA | MGI Sequence Detail 1727 Not Applicable 
polypeptide OTTMUSP00000004468 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(5) UniProt(7)
Polymorphisms
SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003000 Sirtuin family
InterPro IPR026590 Sirtuin family, catalytic core domain
InterPro IPR026591 Sirtuin family, catalytic core small domain
Protein Ontology PR:000014893 NAD-dependent protein deacetylase sirtuin-7
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:205529 Shin J, et al., SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 2013 Nov 14;5(3):654-65
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory