Rin3 MGI Mouse Gene Detail - MGI:2385708 - Ras and Rab interactor 3

Symbol

Rin3
Name

Ras and Rab interactor 3

Feature Type

protein coding gene
IDs

MGI:2385708
NCBI Gene: 217835
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:102283048-102390855 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 51.45 cM
Mapping Data

2 experiments

SNPs within 2kb

816 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385708	protein coding gene	Chr12:102282840-102390855 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020030	protein coding gene	Chr12:103908644-104019277 (+)
A/J	MGP_AJ_G0019986	protein coding gene	Chr12:99916394-100034550 (+)
AKR/J	MGP_AKRJ_G0019962	protein coding gene	Chr12:102759371-102874124 (+)
BALB/cJ	MGP_BALBcJ_G0019972	protein coding gene	Chr12:100256307-100364086 (+)
C3H/HeJ	MGP_C3HHeJ_G0019774	protein coding gene	Chr12:103215668-103333309 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020421	protein coding gene	Chr12:107160937-107272285 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018034	protein coding gene	Chr12:96943049-97056617 (+)
CAST/EiJ	MGP_CASTEiJ_G0019320	protein coding gene	Chr12:98047215-98164366 (+)
CBA/J	MGP_CBAJ_G0019746	protein coding gene	Chr12:111122595-111240246 (+)
DBA/2J	MGP_DBA2J_G0019857	protein coding gene	Chr12:99439899-99551981 (+)
FVB/NJ	MGP_FVBNJ_G0019846	protein coding gene	Chr12:98163532-98280116 (+)
LP/J	MGP_LPJ_G0019933	protein coding gene	Chr12:103762269-103876316 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019886	protein coding gene	Chr12:114598691-114715804 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020450	protein coding gene	Chr12:102267219-102375595 (+)
PWK/PhJ	MGP_PWKPhJ_G0019083	protein coding gene	Chr12:93994156-94104212 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018879	protein coding gene	Chr12:96440274-96551241 (+)
WSB/EiJ	MGP_WSBEiJ_G0019374	protein coding gene	Chr12:103152416-103266942 (+)

Human Ortholog

RIN3, Ras and Rab interactor 3

Vertebrate Orthologs

6

Human Ortholog

RIN3, Ras and Rab interactor 3
Orthology source: HomoloGene, HGNC
Links

HGNC:18751

NCBI Gene ID: 79890

neXtProt AC: NX_Q8TB24

UniProt: Q8TB24
Chr Location

14q32.12; chr14:92513773-92688994 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11748
1 human;1 mouse;1 rat;1 chimpanzee;1 chicken;1 frog, western clawed
HCOP

human homology predictions: RIN3
Gene Tree

Rin3

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Targeted

5
Genomic Mutations

1 involving Rin3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

635
Tissues

1
cDNA Data

16
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rin3

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Rin3 interacts with 172 markers (Mir15a, Mir23a, Mir23b, ...) View All

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All Sequences

70
RefSeq

10
UniProt

8
CCDS

CCDS26118.1, CCDS49145.1

Ensembl

ENSMUSG00000044456 (Evidence)
NCBI Gene

217835

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044456	Ensembl Gene Model \| MGI Sequence Detail	107808	C57BL/6J	± kb
transcript	ENSMUST00000056950	Ensembl \| MGI Sequence Detail	3892	Not Applicable
polypeptide	ENSMUSP00000060771	Ensembl \| MGI Sequence Detail	980	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014015 Ras and Rab interactor 3

(term hierarchy)
InterPro Domains

IPR035869 Ras and Rab interactor 3, SH2 domain

IPR000159 Ras-associating (RA) domain

IPR036860 SH2 domain superfamily

IPR003123 VPS9 domain

IPR037191 VPS9 domain superfamily

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All nucleic 16

cDNA 16

Microarray probesets 5

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MGI:2145127

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:297331 Shen R, et al., Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. Transl Neurodegener. 2020 Jun 18;9(1):26

TSS for Rin3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114737	Chr12:102282861-102282871 (+)	-182 bp
Tssr114738	Chr12:102283036-102283079 (+)	10 bp
Tssr114739	Chr12:102283087-102283096 (+)	44 bp
Tssr114740	Chr12:102283116-102283194 (+)	107 bp
Tssr114741	Chr12:102283203-102283234 (+)	171 bp
Tssr114742	Chr12:102283256-102283274 (+)	217 bp
Tssr114744	Chr12:102354745-102354754 (+)	71,702 bp
Tssr114745	Chr12:102354759-102354821 (+)	71,742 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16