Rin3 MGI Mouse Gene Detail - MGI:2385708 - Ras and Rab interactor 3

Symbol

Rin3
Name

Ras and Rab interactor 3

Feature Type

protein coding gene
IDs

MGI:2385708
NCBI Gene: 217835
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr12:102249307-102357114 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 51.45 cM
Mapping Data

2 experiments

SNPs within 2kb

3991 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385708	protein coding gene	Chr12:102248572-102358982 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020030	protein coding gene	Chr12:103908644-104019277 (+)
A/J	MGP_AJ_G0019986	protein coding gene	Chr12:99916394-100034550 (+)
AKR/J	MGP_AKRJ_G0019962	protein coding gene	Chr12:102759371-102874124 (+)
BALB/cJ	MGP_BALBcJ_G0019972	protein coding gene	Chr12:100256307-100364086 (+)
C3H/HeJ	MGP_C3HHeJ_G0019774	protein coding gene	Chr12:103215668-103333309 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020421	protein coding gene	Chr12:107160937-107272285 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018034	protein coding gene	Chr12:96943049-97056617 (+)
CAST/EiJ	MGP_CASTEiJ_G0019320	protein coding gene	Chr12:98047215-98164366 (+)
CBA/J	MGP_CBAJ_G0019746	protein coding gene	Chr12:111122595-111240246 (+)
DBA/2J	MGP_DBA2J_G0019857	protein coding gene	Chr12:99439899-99551981 (+)
FVB/NJ	MGP_FVBNJ_G0019846	protein coding gene	Chr12:98163532-98280116 (+)
LP/J	MGP_LPJ_G0019933	protein coding gene	Chr12:103762269-103876316 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019886	protein coding gene	Chr12:114598691-114715804 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020450	protein coding gene	Chr12:102267219-102375595 (+)
PWK/PhJ	MGP_PWKPhJ_G0019083	protein coding gene	Chr12:93994156-94104212 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018879	protein coding gene	Chr12:96440274-96551241 (+)
WSB/EiJ	MGP_WSBEiJ_G0019374	protein coding gene	Chr12:103152416-103266942 (+)

Human Ortholog

RIN3, Ras and Rab interactor 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIN3, Ras and Rab interactor 3
Links

HGNC:18751

NCBI Gene ID: 79890

UniProt: Q8TB24
Chr Location

14q32.12; chr14:92513781-92688994 (+) GRCh38

MGI Vertebrate Homology

Rin3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RIN3
Gene Tree

Rin3

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Phenotype Summary

17 phenotypes from 1 allele in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

5
Genomic Mutations

1 involving Rin3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show an age-dependent increase in trabecular bone volume and trabecular number, a decrease in trabecular separation and osteoclast surface, and increased perimeter occupied by single calcein labels, thus reducing bone resorption and leading to increased bone mass.

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All GO Annotations

40
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

46
cDNA Data

16
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rin3

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All Sequences

70
RefSeq

10
UniProt

8
CCDS

CCDS26118.1, CCDS49145.1

Ensembl

ENSMUSG00000044456 (Evidence)
NCBI Gene

217835

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044456	Ensembl Gene Model \| MGI Sequence Detail	107808	C57BL/6J	± kb
transcript	ENSMUST00000056950	Ensembl \| MGI Sequence Detail	3892	Not Applicable
polypeptide	ENSMUSP00000060771	Ensembl \| MGI Sequence Detail	980	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014015 Ras and Rab interactor 3

(term hierarchy)
InterPro Domains

IPR035869 Ras and Rab interactor 3, SH2 domain

IPR000159 Ras-associating domain

IPR036860 SH2 domain superfamily

IPR045046 Vacuolar protein sorting-associated protein 9-like

IPR003123 VPS9 domain

IPR037191 VPS9 domain superfamily
GlyGen

P59729 6 sites, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 16

Microarray probesets 5

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MGI:2145127

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rin3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114737	Chr12:102249120-102249130 (+)	-182 bp
Tssr114738	Chr12:102249295-102249338 (+)	10 bp
Tssr114739	Chr12:102249346-102249355 (+)	44 bp
Tssr114740	Chr12:102249375-102249453 (+)	107 bp
Tssr114741	Chr12:102249462-102249493 (+)	171 bp
Tssr114742	Chr12:102249515-102249533 (+)	217 bp
Tssr114743	Chr12:102279377-102279407 (+)	30,085 bp
Tssr114744	Chr12:102321004-102321013 (+)	71,702 bp
Tssr114745	Chr12:102321018-102321080 (+)	71,742 bp
Tssr114746	Chr12:102323388-102323411 (+)	74,093 bp
Tssr114747	Chr12:102333626-102333649 (+)	84,331 bp
Tssr114748	Chr12:102334507-102334517 (+)	85,205 bp
Tssr114749	Chr12:102334540-102334580 (+)	85,253 bp
Tssr114750	Chr12:102334605-102334631 (+)	85,311 bp
Tssr114751	Chr12:102334991-102335020 (+)	85,699 bp
Tssr114752	Chr12:102335174-102335195 (+)	85,878 bp
Tssr114753	Chr12:102343422-102343423 (+)	94,116 bp
Tssr114754	Chr12:102350138-102350198 (+)	100,861 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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