Tg(APPSWE)2576Kha
Transgene Detail
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Symbol: |
Tg(APPSWE)2576Kha |
Name: |
transgene insertion 2576, Karen Hsiao Ashe |
MGI ID: |
MGI:2385631 |
Synonyms: |
APP695swe, APPK670N,M671L, APPSw, APPswe Tg2576, hAPP, K670N/M671L, Tg2576, Tg(APPSWE)2576HKahs, Tg(APPSWE)2576Kahs, Tg(HuAPP695.K670-M671L)2576, TgN(APPSWE)2576 |
Transgene: |
Tg(APPSWE)2576Kha Location: unknown
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Alliance: |
Tg(APPSWE)2576Kha page
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Increase of amyloid beta deposits and amyloid beta 40 in the hippocampus and cortex of Vps35Gt(RRK261)Byg/Vps35+ Tg(APPSWE)2576Kha/0 mice
Show the 1 phenotype image(s) involving this allele.
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(APPSWE)2576Kha expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
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The gene encodes the Swedish mutation. |
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Mutation details: Overexpression of the human APP gene encoding the APP695.SWE mutation (K670N and M671L). The construct contained the APP gene fused to the hamster prion protein promoter. APP expression was measured in brains of transgenic mice by quantitation of immunoblots.
(J:29880, J:80638)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 5 strains available
Cell Lines: 0 lines available
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Original: |
J:80638 Hsiao K, et al., Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 1996 Oct 4;274(5284):99-102 |
All: |
717 reference(s) |
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