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Tpcn2
Gene Detail
 Symbol
Name
ID
Tpcn2
two pore segment channel 2
MGI:2385297
Synonyms D830047E22Rik, MGC:32411
Feature Type protein coding gene
Genetic Map
Chromosome 7
89.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:145253923-145283927 bp, - strand
From NCBI annotation of GRCm38

  30005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tpcn2

Human
homologs
Human Homolog TPCN2, two pore segment channel 2
NCBI Gene ID 219931
neXtProt AC  NX_Q8NHX9
Human Synonyms  SHEP10, TPC2
Human Chr (Location)  11q13.3; chr11:69048882-69136059 (+)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit altered beta cell calcium ion physiology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component cell, endosome membrane, ...
Function calcium channel activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (24)   
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 2
Northern blot 10
RT-PCR 18
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000048677 (Evidence)
Entrez Gene233979 (Evidence)
DFCITC1581264, TC1591693, TC1595601, TC1605983
DoTSDT.111017655, DT.111017657, DT.481780, DT.97368945, DT.99712816
NIA Mouse Gene IndexU029530
Consensus CDS ProjectCCDS40203.1
International Mouse Knockout Project StatusTpcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 233979 NCBI Gene Model | MGI Sequence Detail 30005 C57BL/6J ±  kb
transcript NM_146206 RefSeq | MGI Sequence Detail 2909 C57BL/6 
polypeptide Q8BWC0 UniProt | EBI | MGI Sequence Detail 731 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(19) UniProt(4)
Polymorphisms SNPs within 2kb(238 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000001966 two pore calcium channel protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:193600 Cang C, et al., mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na(+) Channels to Adapt to Metabolic State. Cell. 2013 Feb 14;152(4):778-90
All references(37)
Other
accession IDs
MGI:2443261

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory