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Tpcn2
Gene Detail
Symbol

Name
ID
Tpcn2
two pore segment channel 2
MGI:2385297
Synonyms
D830047E22Rik, MGC:32411
Feature Type
protein coding gene
Genetic Map
Chromosome 7
89.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:145253923-145283927 bp, - strand
From Ensembl annotation of GRCm38

  30005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TPCN2
Gene Tree: Tpcn2

Human
homologs
TPCN2, two pore segment channel 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 219931
neXtProt AC: NX_Q8NHX9

Human Synonyms: SHEP10, TPC2

Human Chr (Location): 11q13.3; chr11:69048882-69160413 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele exhibit altered beta cell calcium ion physiology.
 
Interactions
Tpcn2 interacts with 123 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component cell, cytosol, ...
Function calcium channel activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 10
RT-PCR 18
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tpcn2 ; ZFIN tpcn2    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000048677 (Evidence)
Entrez Gene 233979 (Evidence)
DFCI TC1581264, TC1605983, TC1595601, TC1591693
DoTS DT.111017657, DT.111017655, DT.99712816, DT.481780, DT.97368945
NIA Mouse Gene Index U029530
Consensus CDS Project CCDS40203.1
International Mouse Phenotyping Consortium Status Tpcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048677 Ensembl Gene Model | MGI Sequence Detail 30005 C57BL/6J ±  kb
transcript ENSMUST00000058022 Ensembl | MGI Sequence Detail 2909 Not Applicable 
polypeptide ENSMUSP00000061308 Ensembl | MGI Sequence Detail 731 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(29) UniProt(4)
Polymorphisms
SNPs within 2kb(238 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000001966 two pore calcium channel protein 2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:221929 Lear PV, et al., Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue. Endocrinology. 2015 Mar;156(3):975-86
All references(38)
Other
accession IDs
MGI:2443261

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory