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Tpcn2 Gene Detail
Summary
  • Symbol
    Tpcn2
  • Name
    two pore segment channel 2
  • Synonyms
    D830047E22Rik, MGC:32411
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385297
    NCBI Gene: 233979
Location & Maps
more
  • Sequence Map
    Chr7:145253923-145283927 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30005 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TPCN2, two pore segment channel 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPCN2, two pore segment channel 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SHEP10, TPC2
  • Links
    NCBI Gene ID: 219931
    neXtProt AC: NX_Q8NHX9

  • Chr Location
    11q13.3; chr11:69048882-69160413 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 16375
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TPCN2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit altered beta cell calcium ion physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048677 Ensembl Gene Model | MGI Sequence Detail 30005 C57BL/6J ±  kb
transcript ENSMUST00000058022 Ensembl | MGI Sequence Detail 2909 Not Applicable  
polypeptide ENSMUSP00000061308 Ensembl | MGI Sequence Detail 731 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    238 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001966 two pore calcium channel protein 2
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR027359 Voltage-dependent channel, four helix bundle domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
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MGI:2443261
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:222616 Ruas M, et al., Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J. 2015 Jul 2;34(13):1743-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory