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Cnot3 Gene Detail
Summary
  • Symbol
    Cnot3
  • Name
    CCR4-NOT transcription complex, subunit 3
  • Synonyms
    A930039N10Rik, MGC:40675
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385261
    NCBI Gene: 232791
  • Gene Overview
    MyGene.info: CNOT3
Location & Maps
more
  • Genetic Map
    Chromosome 7, 2.10 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CNOT3, CCR4-NOT transcription complex subunit 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CNOT3, CCR4-NOT transcription complex subunit 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LENG2, NOT3, NOT3H
  • Links
    NCBI Gene ID: 4849
    neXtProt AC: NX_O75175

  • Chr Location
    19q13.4; chr19:54137689-54155708 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Gene trapped
    32
  • Targeted
    3
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele show defective outgrowth of the inner cell mass and complete embryonic lethality at implantation. Heterozygotes exhibit decreased cardiac muscle contractility and develop severe cardiomyopathy leading to heart failure in response to pressure overload.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027888 VEGA Gene Model | MGI Sequence Detail 15842 C57BL/6J ±  kb
transcript OTTMUST00000069067 VEGA | MGI Sequence Detail 2822 Not Applicable  
polypeptide OTTMUSP00000035026 VEGA | MGI Sequence Detail 751 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000005651 CCR4-NOT transcription complex subunit 3
  • InterPro Domains
    IPR007207 CCR4-Not complex component, Not N-terminal domain
    IPR012270 CCR4-NOT complex, subunit 3/ 5
    IPR007282 NOT2/NOT3/NOT5
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 1
Other
Accession IDs
less
MGI:2443775
References
more
  • Summaries
    All 35
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:206802 Watanabe C, et al., Stability of mRNA influences osteoporotic bone mass via CNOT3. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2692-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory