Ndufs2
Gene Detail

Symbol

Name
ID

Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
MGI:2385112

Synonyms

MGC:27667

Feature Type

protein coding gene

Genetic Map

Chromosome 1
79.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:171234853-171247122 bp, - strand From VEGA annotation of GRCm38   12270 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:56659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: [NiFe]-hydrogenase-3-type complex, large subunit/NADH:quinone oxidoreductase (complex I), 49K/NdhH/NuoD subunit
Gene Tree: Ndufs2

Human
homologs

Human Homolog		NDUFS2, NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NCBI Gene ID		4720
neXtProt AC		NX_O75306
Human Synonyms		CI-49
Human Chr (Location)		1q23; chr1:161197419-161214395 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human NDUFS2

Mutations,
alleles, and
phenotypes

All mutations/alleles(17) : Gene trapped(17)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Ndufs2 interacts with 40 markers (Mir1b, Mir32, Mir92-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	oxidation-reduction process, response to oxidative stress, ...
Component	membrane, mitochondrial inner membrane, ...
Function	4 iron, 4 sulfur cluster binding, iron-sulfur cluster binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (98)    Tissues (98)    Images (16)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	95
RT-PCR	3

cDNA source data(314)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(317) cDNA(314) Primer pair(3)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000021571 (Evidence)
Ensembl Gene Model	ENSMUSG00000013593 (Evidence)
Entrez Gene	226646 (Evidence)
UniGene	21669
DFCI	TC1573275
DoTS	DT.99864856, DT.97402292, DT.94378964, DT.536843, DT.110838375
NIA Mouse Gene Index	U022047
EC	1.6.99.3, 1.6.5.3
Consensus CDS Project	CCDS15484.1
International Mouse Knockout Project Status	Ndufs2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021571	VEGA Gene Model | MGI Sequence Detail	12270	C57BL/6J
transcript	OTTMUST00000051199	VEGA | MGI Sequence Detail	1623	Not Applicable
polypeptide	OTTMUSP00000024040	VEGA | MGI Sequence Detail	463	Not Applicable

All sequences(68) RefSeq(4) UniProt(5)

Polymorphisms

SNPs within 2kb(322 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001135	NADH-quinone oxidoreductase, subunit D
InterPro	IPR014029	NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site
InterPro	IPR022885	NAD(P)H-quinone oxidoreductase subunit D/H
Protein Ontology	PR:000011097	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:172354 Wirtz S, et al., Region-Specific Expression of Mitochondrial Complex I Genes during Murine Brain Development. PLoS One. 2011;6(4):e18897
All references(38)

Other
accession IDs

MGI:2138402