Ndufs2 MGI Mouse Gene Detail - MGI:2385112 - NADH dehydrogenase (ubiquinone) Fe-S protein 2

Ndufs2 Gene Detail

Symbol

Ndufs2
Name

NADH dehydrogenase (ubiquinone) Fe-S protein 2
Synonyms

MGC:27667

Feature Type

protein coding gene
IDs

MGI:2385112
NCBI Gene: 226646
Gene Overview

MyGene.info: NDUFS2

Sequence Map

Chr1:171234853-171251388 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

16536 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.25 cM
Mapping Data

2 experiments

Human Ortholog

NDUFS2, NADH:ubiquinone oxidoreductase core subunit S2

Vertebrate Orthologs

10

Human Ortholog

NDUFS2, NADH:ubiquinone oxidoreductase core subunit S2
Orthology source: HomoloGene, HGNC
Synonyms

CI-49
Links

HGNC:7708

NCBI Gene ID: 4720

neXtProt AC: NX_O75306

UniProt: O75306
Chr Location

1q23.3; chr1:161197377-161214395 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56659
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NDUFS2
Protein SuperFamily

[NiFe]-hydrogenase-3-type complex, large subunit/NADH:quinone oxidoreductase (complex I), 49K/NdhH/NuoD subunit
Gene Tree

Ndufs2

Diseases

1 with human NDUFS2 associations

				Human Disease	Mouse Models
				mitochondrial complex I deficiency IDs mitochondrial complex I deficiency DOID:0060536 MESH:C537475 OMIM:252010 ORDO:2609 UMLS_CUI:C2936907

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

23
Chemically induced (other)

2
Gene trapped

21
Genomic Mutations

2 involving Ndufs2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

22
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

98
Tissues

98
cDNA Data

314
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Ndufs2 interacts with 40 markers (Mir1b, Mir32, Mir92-2, ...) View All

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All Sequences

71
RefSeq

2
UniProt

4
CCDS

CCDS15484.1
UniGene

21669

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021571	VEGA Gene Model \| MGI Sequence Detail	16536	C57BL/6J	± kb
transcript	OTTMUST00000051199	VEGA \| MGI Sequence Detail	1623	Not Applicable
polypeptide	OTTMUSP00000024040	VEGA \| MGI Sequence Detail	463	Not Applicable

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SNPs within 2kb

306 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000011097 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

(term hierarchy)
EC

1.6.5.3, 1.6.99.3
InterPro Domains

IPR001135 NADH-quinone oxidoreductase, subunit D

IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site

IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H

IPR029014 NiFe hydrogenase-like

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All nucleic 317

cDNA 314

Primer pair 3

Microarray probesets 3

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MGI:2138402

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:172354 Wirtz S, et al., Region-Specific Expression of Mitochondrial Complex I Genes during Murine Brain Development. PLoS One. 2011;6(4):e18897

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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