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Ndufs2 Gene Detail
Summary
  • Symbol
    Ndufs2
  • Name
    NADH dehydrogenase (ubiquinone) Fe-S protein 2
  • Synonyms
    MGC:27667
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385112
    NCBI Gene: 226646
  • Gene Overview
    MyGene.info: NDUFS2
Location & Maps
more
  • Sequence Map
    Chr1:171234853-171251388 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16536 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.25 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NDUFS2, NADH:ubiquinone oxidoreductase core subunit S2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDUFS2, NADH:ubiquinone oxidoreductase core subunit S2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CI-49
  • Links
    NCBI Gene ID: 4720
    neXtProt AC: NX_O75306

  • Chr Location
    1q23; chr1:161197419-161214395 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NDUFS2 associations

Human Disease Mouse Models
       Mitochondrial Complex I Deficiency   OMIM: 252010
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    2
  • Gene trapped
    21
  • Genomic Mutations
    2 involving Ndufs2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021571 VEGA Gene Model | MGI Sequence Detail 16536 C57BL/6J ±  kb
transcript OTTMUST00000051199 VEGA | MGI Sequence Detail 1623 Not Applicable  
polypeptide OTTMUSP00000024040 VEGA | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    306 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011097 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
  • EC
  • InterPro Domains
    IPR001135 NADH-quinone oxidoreductase, subunit D
    IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site
    IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H
    IPR029014 NiFe hydrogenase-like
Molecular
Reagents
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  • All nucleic 317
    cDNA 314
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138402
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:172354 Wirtz S, et al., Region-Specific Expression of Mitochondrial Complex I Genes during Murine Brain Development. PLoS One. 2011;6(4):e18897

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory