Ndufs2 MGI Mouse Gene Detail - MGI:2385112 - NADH:ubiquinone oxidoreductase core subunit S2

Symbol

Ndufs2
Name

NADH:ubiquinone oxidoreductase core subunit S2
Synonyms

MGC:27667

Feature Type

protein coding gene
IDs

MGI:2385112
NCBI Gene: 226646
Gene Overview

MyGene.info: NDUFS2
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:171234853-171251388 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.25 cM
Mapping Data

2 experiments

SNPs within 2kb

306 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385112	protein coding gene	Chr1:171234853-171251686 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016749	protein coding gene	Chr1:177015975-177035400 (-)
A/J	MGP_AJ_G0016729	protein coding gene	Chr1:169816130-169832744 (-)
AKR/J	MGP_AKRJ_G0016695	protein coding gene	Chr1:174903460-174921573 (-)
BALB/cJ	MGP_BALBcJ_G0016690	protein coding gene	Chr1:170298756-170315930 (-)
C3H/HeJ	MGP_C3HHeJ_G0016513	protein coding gene	Chr1:175148307-175165124 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017151	protein coding gene	Chr1:182899115-182918945 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014859	protein coding gene	Chr1:161496366-161513021 (-)
CAST/EiJ	MGP_CASTEiJ_G0016094	protein coding gene	Chr1:174770984-174790077 (-)
CBA/J	MGP_CBAJ_G0016488	protein coding gene	Chr1:189416450-189435564 (-)
DBA/2J	MGP_DBA2J_G0016595	protein coding gene	Chr1:168655801-168672871 (-)
FVB/NJ	MGP_FVBNJ_G0016591	protein coding gene	Chr1:167003950-167020487 (-)
LP/J	MGP_LPJ_G0016666	protein coding gene	Chr1:178136579-178155634 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016618	protein coding gene	Chr1:196698806-196717920 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017188	protein coding gene	Chr1:174774371-174790863 (-)
PWK/PhJ	MGP_PWKPhJ_G0015880	protein coding gene	Chr1:167878138-167894922 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015664	protein coding gene	Chr1:173559083-173575379 (-)
WSB/EiJ	MGP_WSBEiJ_G0016156	protein coding gene	Chr1:174891349-174907951 (-)

Human Ortholog

NDUFS2, NADH:ubiquinone oxidoreductase core subunit S2

Vertebrate Orthologs

10

Human Ortholog

NDUFS2, NADH:ubiquinone oxidoreductase core subunit S2
Orthology source: HomoloGene, HGNC
Synonyms

CI-49, MC1DN6
Links

HGNC:7708

NCBI Gene ID: 4720

neXtProt AC: NX_O75306

UniProt: O75306
Chr Location

1q23.3; chr1:161197377-161214395 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56659
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NDUFS2
Protein SuperFamily

[NiFe]-hydrogenase-3-type complex, large subunit/NADH:quinone oxidoreductase (complex I), 49K/NdhH/NuoD subunit
Gene Tree

Ndufs2

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

21
Targeted

1
Genomic Mutations

2 involving Ndufs2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

20
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

98
cDNA Data

315
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndufs2

less

Ndufs2 interacts with 40 markers (Mir1b, Mir32, Mir92-2, ...) View All

less

All Sequences

79
RefSeq

6
UniProt

4
CCDS

CCDS15484.1
UniGene

21669

Ensembl

ENSMUSG00000013593 (Evidence)
NCBI Gene

226646

			Length	Strain/Species	Flank
genomic	ENSMUSG00000013593	Ensembl Gene Model \| MGI Sequence Detail	16536	C57BL/6J	± kb
transcript	ENSMUST00000013737	Ensembl \| MGI Sequence Detail	1623	Not Applicable
polypeptide	ENSMUSP00000013737	Ensembl \| MGI Sequence Detail	463	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000011097 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

(term hierarchy)
PDB

6G2J, 6G72
EC

1.6.99.3, 7.1.1.2
InterPro Domains

IPR001135 NADH-quinone oxidoreductase, subunit D

IPR038290 NADH-quinone oxidoreductase, subunit D superfamily

IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site

IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H

IPR029014 [NiFe]-hydrogenase, large subunit

less

All nucleic 318

cDNA 315

Primer pair 3

Microarray probesets 3

less

MGI:2138402

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:283318 Ruan QT, et al., A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. J Neurosci. 2020 Jan 2;40(1):107-130

TSS for Ndufs2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15024	Chr1:171251664-171251675 (-)	-282 bp
Tssr15023	Chr1:171247096-171247121 (-)	4,279 bp
Tssr15022	Chr1:171241045-171241059 (-)	10,336 bp
Tssr15021	Chr1:171240107-171240116 (-)	11,276 bp
Tssr15020	Chr1:171237607-171237624 (-)	13,772 bp
Tssr15019	Chr1:171237598-171237606 (-)	13,786 bp
Tssr15018	Chr1:171234698-171234729 (-)	16,674 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 03/24/2020 MGI 6.15