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Eif4g1 Gene Detail
Summary
  • Symbol
    Eif4g1
  • Name
    eukaryotic translation initiation factor 4, gamma 1
  • Synonyms
    E030015G23Rik, MGC:37551
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384784
    NCBI Gene: 208643
Location & Maps
more
  • Sequence Map
    Chr16:20668313-20692884 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24572 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.49 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EIF4G1, eukaryotic translation initiation factor 4 gamma 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EIF4G1, eukaryotic translation initiation factor 4 gamma 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF4F, EIF4G, EIF-4G1, EIF4GI, P220, PARK18
  • Links
    NCBI Gene ID: 1981
    neXtProt AC: NX_Q04637

  • Chr Location
    3q27.1; chr3:184314495-184335358 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human EIF4G1 associations

Human Disease Mouse Models
       Parkinson Disease 18, Autosomal Dominant, Susceptibility To; PARK18   OMIM: 614251
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024386 VEGA Gene Model | MGI Sequence Detail 24572 C57BL/6J ±  kb
transcript OTTMUST00000059747 VEGA | MGI Sequence Detail 5444 Not Applicable  
polypeptide OTTMUSP00000029085 VEGA | MGI Sequence Detail 1600 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 476
    cDNA 476

    Microarray probesets 7
Other
Accession IDs
less
MGI:2443563
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:224214 Truitt ML, et al., Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 2;162(1):59-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory