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Ash1l
Gene Detail
Symbol

Name
ID
Ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
MGI:2183158
Synonyms
8030453L17Rik, chromatin remodeling factor, E430018P19Rik, KMT2H
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:88950622-89079375 bp, + strand
From VEGA annotation of GRCm38

  128754 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10225  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Ash1l

Human
homologs
Human Homolog ASH1L, ash1 (absent, small, or homeotic)-like (Drosophila)
NCBI Gene ID 55870
neXtProt AC  NX_Q9NR48
Human Synonyms  ASH1, ASH1L1, KMT2H
Human Chr (Location)  1q22; chr1:155335261-155562825 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(1) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a transposon-induced allele exhibit increased susceptibility to autoimmune disease and induced arthritis.
 
Interactions
Ash1l interacts with 456 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process chromatin modification, histone H3-K4 methylation, ...
Component cell junction, chromosome, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (126)    Tissues (117)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
RT-PCR 8
cDNA source data(120)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(121) cDNA(120) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000047367 (Evidence)
Ensembl Gene ModelENSMUSG00000028053 (Evidence)
Entrez Gene192195 (Evidence)
UniGene130752
DFCITC1577773, TC1598084, TC1598302, TC1654948, TC1729883
DoTSDT.101378611, DT.101707537, DT.101716224, DT.40151644, DT.94231836
NIA Mouse Gene IndexU220219
EC2.1.1.43
Consensus CDS ProjectCCDS17487.1
International Mouse Knockout Project StatusAsh1l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047367 VEGA Gene Model | MGI Sequence Detail 128754 C57BL/6J ±  kb
transcript OTTMUST00000122389 VEGA | MGI Sequence Detail 11644 Not Applicable 
polypeptide OTTMUSP00000067155 VEGA | MGI Sequence Detail 2958 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(452 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR006560 AWS
InterPro IPR001025 Bromo adjacent homology (BAH) domain
InterPro IPR001487 Bromodomain
InterPro IPR003616 Post-SET domain
InterPro IPR001214 SET domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000030913 histone-lysine N-methyltransferase ASH1L
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:208213 Xia M, et al., Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. Immunity. 2013 Sep 19;39(3):470-81
All references(40)
Other
accession IDs
MGI:2442216, MGI:2444414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory