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Irak4
Gene Detail
 Symbol
Name
ID
Irak4
interleukin-1 receptor-associated kinase 4
MGI:2182474
Synonyms 8430405M07Rik, 9330209D03Rik, IRAK-4, NY-REN-64
Feature Type protein coding gene
Genetic Map
Chromosome 15
48.55 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:94543643-94581815 bp, + strand
From VEGA annotation of GRCm38

  38173 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41109  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interleukin-1 receptor-associated kinase 4
Gene Tree: Irak4

Human
homologs
Human Homolog IRAK4, interleukin-1 receptor-associated kinase 4
NCBI Gene ID 51135
neXtProt AC  NX_Q9NWZ3
Human Synonyms  IPD1, IRAK-4, NY-REN-64, REN64
Human Chr (Location)  12q12; chr12:43758944-43789543 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human IRAK4
Alleles
and
phenotypes
All alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit defects of the innate immune system and show increased susceptibility to bacterial infection.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cytokine-mediated signaling pathway, cytokine production, ...
Component cytoplasm, extracellular space, ...
Function ATP binding, interleukin-1 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (78)    Tissues (55)    Images (15)
Theiler Stages: 17, 19, 20, 23, 28
Assay TypeResults
RNA in situ 67
RT-PCR 11
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016696 (Evidence)
Ensembl Gene ModelENSMUSG00000059883 (Evidence)
Entrez Gene266632 (Evidence)
UniGene422858
DFCITC1583627, TC1593747, TC1624779
DoTSDT.110832863, DT.55165161, DT.97343443
NIA Mouse Gene IndexU016602
EC2.7.11.1
PDB2A9I, 1WH4
Consensus CDS ProjectCCDS27772.1
International Mouse Knockout Project StatusIrak4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016696 VEGA Gene Model | MGI Sequence Detail 38173 C57BL/6J ±  kb
transcript OTTMUST00000040437 VEGA | MGI Sequence Detail 2831 Not Applicable 
polypeptide OTTMUSP00000018065 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(378 from dbSNP Build 137)    SNPs within 2kb including multiple locations(384)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR017428 Interleukin-1 receptor-associated kinase 4
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000001780 interleukin-1 receptor-associated kinase 4
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206369 Lin KM, et al., IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):775-80
All references(68)
Other
accession IDs
MGI:1918735, MGI:1924812

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory