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Irak4 Gene Detail
Summary
  • Symbol
    Irak4
  • Name
    interleukin-1 receptor-associated kinase 4
  • Synonyms
    8430405M07Rik, 9330209D03Rik, IRAK-4, NY-REN-64
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182474
    NCBI Gene: 266632
Location & Maps
more
  • Sequence Map
    Chr15:94543643-94581815 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38173 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IRAK4, interleukin 1 receptor associated kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IRAK4, interleukin 1 receptor associated kinase 4
    Orthology source: HomoloGene
  • Synonyms
    IPD1, IRAK-4, NY-REN-64, REN64
  • Links
    NCBI Gene ID: 51135
    neXtProt AC: NX_Q9NWZ3

  • Chr Location
    12q12; chr12:43758944-43789543 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human IRAK4 associations

Human Disease Mouse Models
       IRAK4 Deficiency   OMIM: 607676
Invasive Pneumococcal Disease, Recurrent Isolated, 1; IPD1   OMIM: 610799
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Irak4
  • Incidental Mutations
Homozygous mutant mice exhibit defects of the innate immune system and show increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016696 VEGA Gene Model | MGI Sequence Detail 38173 C57BL/6J ±  kb
transcript OTTMUST00000040437 VEGA | MGI Sequence Detail 2831 Not Applicable  
polypeptide OTTMUSP00000018065 VEGA | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    372 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1918735, MGI:1924812
References
more
  • Summaries
    All 71
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 9
    Phenotypes 48
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224475 Mager LF, et al., IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest. 2015 Jul 1;125(7):2579-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory