Irak4
Gene Detail

Symbol Name ID

Irak4 interleukin-1 receptor-associated kinase 4 MGI:2182474

Synonyms

8430405M07Rik, 9330209D03Rik, IRAK-4, NY-REN-64

Feature Type

protein coding gene

Genetic Map

Chromosome 15

48.55 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:94543643-94581815 bp, + strand From VEGA annotation of GRCm38   38173 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41109  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interleukin-1 receptor-associated kinase 4
Gene Tree: Irak4

Human homologs

Human Homolog		IRAK4, interleukin-1 receptor-associated kinase 4
NCBI Gene ID		51135
neXtProt AC		NX_Q9NWZ3
Human Synonyms		IPD1, IRAK-4, NY-REN-64, REN64
Human Chr (Location)		12q12; chr12:44152747-44183346 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IRAK4

Alleles and phenotypes

All alleles(6) : Targeted(5) Chemically induced(1)
 

Homozygous mutant mice exhibit defects of the innate immune system and show increased susceptibility to bacterial infection.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cytokine-mediated signaling pathway, cytokine production, ...
Component	cytoplasm
Function	ATP binding, interleukin-1 receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (78)    Tissues (55)    Images (15)
Theiler Stages: 17, 19, 20, 23, 28

Assay Type	Results
RNA in situ	67
RT-PCR	11

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016696 (Evidence)
Ensembl Gene Model	ENSMUSG00000059883 (Evidence)
Entrez Gene	266632 (Evidence)
UniGene	422858
DFCI	TC1583627, TC1593747, TC1624779
DoTS	DT.110832863, DT.55165161, DT.97343443
NIA Mouse Gene Index	U016602
EC	2.7.11.1
PDB	2A9I, 1WH4
Consensus CDS Project	CCDS27772.1
International Mouse Knockout Project Status	Irak4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016696	VEGA Gene Model | MGI Sequence Detail	38173	C57BL/6J
transcript	OTTMUST00000040437	VEGA | MGI Sequence Detail	2831	Not Applicable
polypeptide	OTTMUSP00000018065	VEGA | MGI Sequence Detail	459	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(171 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR017428	Interleukin-1 receptor-associated kinase 4
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000001780	interleukin-1 receptor-associated kinase 4
Protein Ontology	PR:000027268	interleukin-1 receptor-associated kinase 4 (mouse)

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190825 Pennini ME, et al., Complete Dependence on IRAK4 Kinase Activity in TLR2, but Not TLR4, Signaling Pathways Underlies Decreased Cytokine Production and Increased Susceptibility to Streptococcus pneumoniae Infection in IRAK4 Kinase-Inactive Mice. J Immunol. 2013 Jan 1;190(1):307-16
All references(64)

Other accession IDs

MGI:1918735, MGI:1924812