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Tox Gene Detail
Summary
  • Symbol
    Tox
  • Name
    thymocyte selection-associated high mobility group box
  • Synonyms
    1700007F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181659
    NCBI Gene: 252838
  • Gene Overview
    MyGene.info: TOX
Location & Maps
more
  • Sequence Map
    Chr4:6686353-6991557 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      305205 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 3.04 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TOX, thymocyte selection associated high mobility group box
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOX, thymocyte selection associated high mobility group box
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TOX1
  • Links
    NCBI Gene ID: 9760
    neXtProt AC: NX_O94900

  • Chr Location
    8q12.1; chr8:58805418-59119208 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8822
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TOX
  • Gene Tree
    Tox
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a knock-out allele have a severe block in thymic positive selection leading to loss of CD4 T lineage cells, and display decreased NK cell numbers, severely reduced numbers of lymphoid tissue inducer cells, absence of all peripheral lymph nodes, and loss of Peyer's patches.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004332 VEGA Gene Model | MGI Sequence Detail 305205 C57BL/6J ±  kb
transcript OTTMUST00000009810 VEGA | MGI Sequence Detail 3961 Not Applicable  
polypeptide OTTMUSP00000004712 VEGA | MGI Sequence Detail 526 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2098 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016555 thymocyte selection-associated high mobility group box protein TOX
  • PDB
  • InterPro Domains
    IPR009071 High mobility group box domain
Molecular
Reagents
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  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1923819
References
more
  • Summaries
    All 41
    Developmental Gene Expression 11
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232838 Seehus CR, et al., The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Nat Immunol. 2015 Jun;16(6):599-608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory