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Tox
Gene Detail
Symbol

Name
ID
Tox
thymocyte selection-associated high mobility group box
MGI:2181659
Synonyms
1700007F02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
3.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:6686353-6991557 bp, - strand
From VEGA annotation of GRCm38

  305205 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8822  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TOX
Gene Tree: Tox

Human
homologs
TOX, thymocyte selection-associated high mobility group box
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9760
neXtProt AC: NX_O94900

Human Synonyms: TOX1

Human Chr (Location): 8q12.1; chr8:58805418-59119208 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele have a severe block in thymic positive selection leading to loss of CD4 T lineage cells, and display decreased NK cell numbers, severely reduced numbers of lymphoid tissue inducer cells, absence of all peripheral lymph nodes, and loss of Peyer's patches.
 
Interactions
Tox interacts with 345 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process chromatin remodeling, regulation of transcription, DNA-templated
Component nucleus
Function chromatin binding, DNA binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (434)    Tissues (133)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 426
RT-PCR 8
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tox    NEW 
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000004332 (Evidence)
Ensembl Gene Model ENSMUSG00000041272 (Evidence)
Entrez Gene 252838 (Evidence)
DFCI TC1649256, TC1609257, TC1595355, TC1777959, TC1579549, TC1665902
DoTS DT.101356496, DT.55146215, DT.60103655, DT.94240864, DT.99857301, DT.97372801
NIA Mouse Gene Index U024825
PDB 2CO9
Consensus CDS Project CCDS17953.1
International Mouse Phenotyping Consortium Status Tox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004332 VEGA Gene Model | MGI Sequence Detail 305205 C57BL/6J ±  kb
transcript OTTMUST00000009810 VEGA | MGI Sequence Detail 3961 Not Applicable 
polypeptide OTTMUSP00000004712 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(2114 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2120)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000016555 thymocyte selection-associated high mobility group box protein TOX
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220033 Artegiani B, et al., Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis. EMBO J. 2015 Apr 1;34(7):896-910
All references(44)
Other
accession IDs
MGI:1923819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory