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Tox
Gene Detail
 Symbol
Name
ID
Tox
thymocyte selection-associated high mobility group box
MGI:2181659
Synonyms 1700007F02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
3.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:6686353-6991557 bp, - strand
From VEGA annotation of GRCm38

  305205 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8822  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tox

Human
homologs
Human Homolog TOX, thymocyte selection-associated high mobility group box
NCBI Gene ID 9760
neXtProt AC  NX_O94900
Human Synonyms  TOX1
Human Chr (Location)  8q12.1; chr8:58805418-59119208 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele have a severe block in thymic positive selection leading to loss of CD4 T lineage cells, and display decreased NK cell numbers, severely reduced numbers of lymphoid tissue inducer cells, absence of all peripheral lymph nodes, and loss of Peyer's patches.
 
Interactions
Tox interacts with 345 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Component nucleus
Function DNA binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (434)    Tissues (133)    Images (34)
Theiler Stages: 2, 3, 4, 5, 12, 14, 17, 18, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 426
RT-PCR 8
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000004332 (Evidence)
Ensembl Gene ModelENSMUSG00000041272 (Evidence)
Entrez Gene252838 (Evidence)
DFCITC1579549, TC1595355, TC1609257, TC1649256, TC1665902, TC1777959
DoTSDT.101356496, DT.55146215, DT.60103655, DT.94240864, DT.97372801, DT.99857301
NIA Mouse Gene IndexU024825
PDB2CO9
Consensus CDS ProjectCCDS17953.1
International Mouse Knockout Project StatusTox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004332 VEGA Gene Model | MGI Sequence Detail 305205 C57BL/6J ±  kb
transcript OTTMUST00000009810 VEGA | MGI Sequence Detail 3961 Not Applicable 
polypeptide OTTMUSP00000004712 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(2114 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2120)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000016555 thymocyte selection-associated high mobility group box protein TOX
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:179593 Aliahmad P, et al., TOX is required for development of the CD4 T cell lineage gene program. J Immunol. 2011 Dec 1;187(11):5931-40
All references(40)
Other
accession IDs
MGI:1923819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory