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Mkrn3 Gene Detail
Summary
  • Symbol
    Mkrn3
  • Name
    makorin, ring finger protein, 3
  • Synonyms
    D7H15S9-1, Zfp127
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181178
    NCBI Gene: 22652
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:62417593-62420139 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 34.37 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181178
protein coding gene Chr7:62417593-62420139 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032328
protein coding gene Chr7:63500785-63503331 (-)
A/J MGP_AJ_G0032307
protein coding gene Chr7:62298925-62301471 (-)
AKR/J MGP_AKRJ_G0032243
protein coding gene Chr7:63617028-63619574 (-)
BALB/cJ MGP_BALBcJ_G0032319
protein coding gene Chr7:61983192-61985750 (-)
C3H/HeJ MGP_C3HHeJ_G0032032
protein coding gene Chr7:64226392-64228938 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032812
protein coding gene Chr7:66266184-66268730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029819
protein coding gene Chr7:65325049-65327602 (-)
CAST/EiJ MGP_CASTEiJ_G0031361
protein coding gene Chr7:55002934-55005486 (-)
CBA/J MGP_CBAJ_G0031998
protein coding gene Chr7:68398362-68400908 (-)
DBA/2J MGP_DBA2J_G0032154
protein coding gene Chr7:61120250-61122802 (-)
FVB/NJ MGP_FVBNJ_G0032108
protein coding gene Chr7:61165931-61168477 (-)
LP/J MGP_LPJ_G0032234
protein coding gene Chr7:64702281-64704827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032145
protein coding gene Chr7:68634651-68637242 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032829
protein coding gene Chr7:62882645-62885191 (-)
PWK/PhJ MGP_PWKPhJ_G0031081
protein coding gene Chr7:54096410-54098963 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030922
protein coding gene Chr7:50007277-50009817 (-)
WSB/EiJ MGP_WSBEiJ_G0031479
protein coding gene Chr7:63260452-63262998 (-)



Homology
more
  • Human Ortholog
    MKRN3, makorin ring finger protein 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MKRN3, makorin ring finger protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPPB2, D15S9, RNF63, ZFP127, ZNF127
  • Links
    NCBI Gene ID: 7681
    neXtProt AC: NX_Q13064
    UniProt: Q13064

  • Chr Location
    15q11.2; chr15:23565307-23568020 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MKRN3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22652 NCBI Gene Model | MGI Sequence Detail 2547 C57BL/6J ±  kb
transcript NM_011746 RefSeq | MGI Sequence Detail 2561 C57BL/6  
polypeptide Q60764 UniProt | EBI | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 13
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15910, MGD-MRK-7794, MGI:99158
References
more
  • Summaries
    All 67
    Developmental Gene Expression 13
    Diseases 4
    Gene Ontology 3
    Phenotypes 26
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:260252 Nakai N, et al., Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice. Sci Adv. 2017 Jun;3(6):e1603001

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory