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Mkrn3 Gene Detail
Summary
  • Symbol
    Mkrn3
  • Name
    makorin, ring finger protein, 3
  • Synonyms
    D7H15S9-1, Zfp127
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181178
    NCBI Gene: 22652
Location & Maps
more
  • Sequence Map
    Chr7:62417593-62420139 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2547 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MKRN3, makorin ring finger protein 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MKRN3, makorin ring finger protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPPB2, D15S9, RNF63, ZFP127, ZNF127
  • Links
    NCBI Gene ID: 7681
    neXtProt AC: NX_Q13064

  • Chr Location
    15q11-q13; chr15:23565307-23568020 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human MKRN3 associations

Human Disease Mouse Models
       Prader-Willi Syndrome; PWS   OMIM: 176270
Precocious Puberty, Central, 2; CPPB2   OMIM: 615346
Click on a disease name to see all genes associated with that disease.

  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    4 involving Mkrn3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22652 NCBI Gene Model | MGI Sequence Detail 2547 C57BL/6J ±  kb
transcript NM_011746 RefSeq | MGI Sequence Detail 2565 C57BL/6  
polypeptide Q60764 UniProt | EBI | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    32 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 2
    cDNA 12
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15910, MGD-MRK-7794, MGI:99158
References
more
  • Summaries
    All 41
    Developmental Gene Expression 14
    Diseases 7
    Gene Ontology 3
    Phenotypes 23
  • Earliest
    J:4101 Nicholls RD, et al., Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2050-4
  • Latest
    J:217174 Nakagaki A, et al., Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014 Dec 10;553(1):63-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory