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Mkrn3
Gene Detail
Symbol

Name
ID
Mkrn3
makorin, ring finger protein, 3
MGI:2181178
Synonyms
D7H15S9-1, Zfp127
Feature Type
protein coding gene
Genetic Map
Chromosome 7
34.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr7:62417593-62420139 bp, - strand
From NCBI annotation of GRCm38

  2547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4143  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MKRN3
Gene Tree: Mkrn3

Human
homologs
MKRN3, makorin ring finger protein 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7681
neXtProt AC: NX_Q13064

Human Synonyms: CPPB2, D15S9, RNF63, ZFP127, ZNF127

Human Chr (Location): 15q11-q13; chr15:23565307-23568020 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MKRN3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(2) Transgenic(1)
Genomic Mutations involving Mkrn3 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Mutations Annotated to Human Diseases (2)   
Interactions
Mkrn3 interacts with 209 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (127)    Tissues (19)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
Northern blot 6
RT-PCR 3
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mkrn3    NEW 
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(12) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000070527 (Evidence)
Entrez Gene 22652 (Evidence)
UniGene 146
DFCI TC1583653
DoTS DT.111001171, DT.50315782, DT.94213393
NIA Mouse Gene Index U028661
EC 6.3.2.-
Consensus CDS Project CCDS21327.1
International Mouse Phenotyping Consortium Status Mkrn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22652 NCBI Gene Model | MGI Sequence Detail 2547 C57BL/6J ±  kb
transcript NM_011746 RefSeq | MGI Sequence Detail 2565 C57BL/6 
polypeptide Q60764 UniProt | EBI | MGI Sequence Detail 544 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026294 Makorin 3
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR000571 Zinc finger, CCCH-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000010433 makorin-3
Graphical View of Protein Domain Structure
References
(Earliest) J:4101 Nicholls RD, et al., Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2050-4
(Latest) J:217174 Nakagaki A, et al., Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014 Dec 10;553(1):63-8
All references(44)
Other
accession IDs
MGD-MRK-15910, MGD-MRK-7794, MGI:99158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory