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Mkrn3
Gene Detail
 Symbol
Name
ID
Mkrn3
makorin, ring finger protein, 3
MGI:2181178
Synonyms D7H15S9-1, Zfp127
Feature Type protein coding gene
Genetic Map
Chromosome 7
34.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr7:62417593-62420139 bp, - strand
From NCBI annotation of GRCm38

  2547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4143  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mkrn3

Human
homologs
Human Homolog MKRN3, makorin ring finger protein 3
NCBI Gene ID 7681
neXtProt AC  NX_Q13064
Human Synonyms  CPPB2, D15S9, RNF63, ZFP127, ZNF127
Human Chr (Location)  15q11-q13; chr15:23565307-23568020 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MKRN3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(2) Transgenic(1)
Genomic Mutations involving Mkrn3 (2)
Incidental mutations (data from Mutagenetix , APF )
Alleles Annotated to Human Diseases(2)   
Interactions
Mkrn3 interacts with 209 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (127)    Tissues (19)    Images (24)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 118
Northern blot 6
RT-PCR 3
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(12) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000070527 (Evidence)
Entrez Gene22652 (Evidence)
UniGene146
DFCITC1583653
DoTSDT.111001171, DT.50315782, DT.94213393
NIA Mouse Gene IndexU028661
EC6.3.2.-
Consensus CDS ProjectCCDS21327.1
International Mouse Knockout Project StatusMkrn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22652 NCBI Gene Model | MGI Sequence Detail 2547 C57BL/6J ±  kb
transcript NM_011746 RefSeq | MGI Sequence Detail 2565 C57BL/6 
polypeptide Q60764 UniProt | EBI | MGI Sequence Detail 544 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026294 Makorin 3
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR000571 Zinc finger, CCCH-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000010433 makorin-3
Graphical View of Protein Domain Structure
References (Earliest) J:4101 Nicholls RD, et al., Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2050-4
(Latest) J:181833 Messerschmidt DM, et al., Trim28 is required for epigenetic stability during mouse oocyte to embryo transition. Science. 2012 Mar 23;335(6075):1499-502
All references(44)
Other
accession IDs
MGD-MRK-15910, MGD-MRK-7794, MGI:99158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory