Xpnpep2
Gene Detail

Symbol Name ID

Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound MGI:2180001

Synonyms

9030008G12Rik, mAPP

Feature Type

protein coding gene

Genetic Map

Chromosome X

25.52 cM, cytoband A3.2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:48108725-48136981 bp, + strand From VEGA annotation of GRCm38   28257 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37766  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: pig X-Pro aminopeptidase
Gene Tree: Xpnpep2

Human homologs

Human Homolog		XPNPEP2, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
NCBI Gene ID		7512
neXtProt AC		NX_O43895
Human Synonyms		APP2
Human Chr (Location)		Xq25; chrX:128872946-128903525 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human XPNPEP2

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	biological_process
Component	cellular_component
Function	aminopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (7)    Images (18)
Theiler Stages: 23

Assay Type	Results
RNA in situ	28

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000017507 (Evidence)
Ensembl Gene Model	ENSMUSG00000037005 (Evidence)
Entrez Gene	170745 (Evidence)
UniGene	129279
DFCI	TC1583628, TC1739667
DoTS	DT.101237170, DT.101721278, DT.91339563
NIA Mouse Gene Index	U019834
EC	3.4.11.9
Consensus CDS Project	CCDS30106.1
International Mouse Knockout Project Status	Xpnpep2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017507	VEGA Gene Model | MGI Sequence Detail	28257	C57BL/6J
transcript	OTTMUST00000042503	VEGA | MGI Sequence Detail	3184	Not Applicable
polypeptide	OTTMUSP00000019100	VEGA | MGI Sequence Detail	741	Not Applicable

All sequences(43) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(403 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000587	Creatinase
InterPro	IPR001131	Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
InterPro	IPR000994	Peptidase M24, structural domain
Protein Ontology	PR:000017496	Xaa-Pro aminopeptidase 2

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:178354 Sherwood RI, et al., Wnt signaling specifies and patterns intestinal endoderm. Mech Dev. 2011 Sep;128(7-10):387-400
All references(30)

Other accession IDs

MGI:2442316