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Zfp366 Gene Detail
Summary
  • Symbol
    Zfp366
  • Name
    zinc finger protein 366
  • Synonyms
    DC-SCRIPT
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178429
    NCBI Gene: 238803
  • Gene Overview
    MyGene.info: ZNF366
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:99184823-99247032 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 52.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178429
protein coding gene Chr13:99184823-99250656 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020873
protein coding gene Chr13:100964480-101026818 (+)
A/J MGP_AJ_G0020827
protein coding gene Chr13:97089404-97153510 (+)
AKR/J MGP_AKRJ_G0020801
protein coding gene Chr13:100064033-100125849 (+)
BALB/cJ MGP_BALBcJ_G0020825
protein coding gene Chr13:97793458-97857191 (+)
C3H/HeJ MGP_C3HHeJ_G0020616
protein coding gene Chr13:99798442-99861070 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021259
protein coding gene Chr13:103959713-104026847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018828
protein coding gene Chr13:92822829-92886516 (+)
CAST/EiJ MGP_CASTEiJ_G0020134
protein coding gene Chr13:99155392-99258942 (+)
CBA/J MGP_CBAJ_G0020576
protein coding gene Chr13:108110169-108173633 (+)
DBA/2J MGP_DBA2J_G0020701
protein coding gene Chr13:96854571-96922598 (+)
FVB/NJ MGP_FVBNJ_G0020682
protein coding gene Chr13:95603180-95666239 (+)
LP/J MGP_LPJ_G0020776
protein coding gene Chr13:101064762-101129915 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020710
protein coding gene Chr13:108409550-108473634 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021300
protein coding gene Chr13:99508009-99573659 (+)
PWK/PhJ MGP_PWKPhJ_G0019887
protein coding gene Chr13:95674676-95737948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019710
protein coding gene Chr13:95804907-95866768 (+)
WSB/EiJ MGP_WSBEiJ_G0020192
protein coding gene Chr13:99946928-100012021 (+)



Homology
more
  • Human Ortholog
    ZNF366, zinc finger protein 366
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZNF366, zinc finger protein 366
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCSCRIPT, DC-SCRIPT
  • Links
    NCBI Gene ID: 167465
    neXtProt AC: NX_Q8N895
    UniProt: Q8N895

  • Chr Location
    5q13.2; chr5:72439899-72507422 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17637
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZNF366
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Zfp366 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    17 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit perimembranous and muscular ventricular septal defects (VSD), and overriding aorta. Short snout, micrognathia, micropthalmia, hypoplastic thymus, and hydronephrosis are also observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 238803 NCBI Gene Model | MGI Sequence Detail 62210 C57BL/6J ±  kb
transcript NM_001004149 RefSeq | MGI Sequence Detail 2788 C57BL/6  
polypeptide Q6NS86 UniProt | EBI | MGI Sequence Detail 746 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Diseases 1
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:108659 Triantis V, et al., Molecular characterization of the murine homologue of the DC-derived protein DC-SCRIPT. J Leukoc Biol. 2006 May;79(5):1083-91
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory