About   Help   FAQ
Clstn3 Gene Detail
Summary
  • Symbol
    Clstn3
  • Name
    calsyntenin 3
  • Synonyms
    alcadein-beta, Cst-3, CSTN3, mKIAA0726
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178323
    NCBI Gene: 232370
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:124430759-124464794 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34036 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.15 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CLSTN3, calsyntenin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLSTN3, calsyntenin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    alcbeta, CDHR14, CSTN3
  • Links
    NCBI Gene ID: 9746
    neXtProt AC: NX_Q9BQT9
    UniProt: Q9BQT9

  • Chr Location
    12p13.31; chr12:7130371-7158945 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22836
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLSTN3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reductions in excitatory and inhibitory synapse density and deficits in synaptic transmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022801 VEGA Gene Model | MGI Sequence Detail 34036 C57BL/6J ±  kb
    transcript OTTMUST00000054787 VEGA | MGI Sequence Detail 4014 Not Applicable  
    polypeptide OTTMUSP00000026175 VEGA | MGI Sequence Detail 956 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      242 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:80943 Hintsch G, et al., The calsyntenins-a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol Cell Neurosci. 2002 Nov;21(3):393-409
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory