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Dicer1
Gene Detail
 Symbol
Name
ID
Dicer1
dicer 1, ribonuclease type III
MGI:2177178
Synonyms 1110006F08Rik, D12Ertd7e, Dicer1, mKIAA0928
Feature Type protein coding gene
Genetic Map
Chromosome 12
54.83 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:104687742-104751952 bp, - strand
From NCBI annotation of GRCm38

  64211 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13251  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dicer1

Human
homologs
Human Homolog DICER1, dicer 1, ribonuclease type III
NCBI Gene ID 23405
neXtProt AC  NX_Q9UPY3
Human Synonyms  DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2
Human Chr (Location)  14q32.13; chr14:95086228-95157422 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DICER1
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Endonuclease-mediated(3) Gene trapped(11) Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
 
Mutation of this locus results in arrest of early embryonic development.
 
Human Diseases Modeled Using Mouse Dicer1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Dicer1 interacts with 439 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (107 annotations)
Process anatomical structure development, angiogenesis, ...
Component axon, cytoplasm, ...
Function ATP binding, double-stranded RNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (318)    Tissues (127)    Images (50)
Theiler Stages: 2, 3, 10, 16, 18, 19, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 248
Northern blot 20
Western blot 2
RT-PCR 48
cDNA source data(167)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(176) cDNA(167) Primer pair(7) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000041415 (Evidence)
Entrez Gene192119 (Evidence)
UniGene21135
DFCITC1577504, TC1615862, TC1629974, TC1642847
DoTSDT.101150704, DT.101307454, DT.40140525, DT.528104, DT.91352884
NIA Mouse Gene IndexU034309
EC3.1.26.3
PDB3C4B, 3C4T
Consensus CDS ProjectCCDS36539.1
International Mouse Knockout Project StatusDicer1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 192119 NCBI Gene Model | MGI Sequence Detail 64211 C57BL/6J ±  kb
transcript NM_148948 RefSeq | MGI Sequence Detail 9851 Not Specified 
polypeptide Q8R418 UniProt | EBI | MGI Sequence Detail 1916 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(7)
Polymorphisms SNPs within 2kb(346 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003100 Argonaute/Dicer protein, PAZ
InterPro IPR005034 Dicer double-stranded RNA-binding fold
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011907 Ribonuclease III
InterPro IPR000999 Ribonuclease III domain
Protein Ontology PR:000006478 endoribonuclease Dicer
Graphical View of Protein Domain Structure
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:212580 Zhang B, et al., A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis. Oncogene. 2014 Jun 12;33(24):3099-108
All references(290)
Disease annotation references (1)
Other
accession IDs
MGI:1098649, MGI:1915712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory