Dicer1
Gene Detail

Symbol Name ID

Dicer1 dicer 1, ribonuclease type III MGI:2177178

Synonyms

1110006F08Rik, D12Ertd7e, Dicer1, mKIAA0928

Feature Type

protein coding gene

Genetic Map

Chromosome 12

54.83 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr12:104687742-104751952 bp, - strand From NCBI annotation of GRCm38   64211 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13251  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dicer1

Human homologs

Human Homolog		DICER1, dicer 1, ribonuclease type III
NCBI Gene ID		23405
neXtProt AC		NX_Q9UPY3
Human Synonyms		DCR1, Dicer, HERNA, MNG1
Human Chr (Location)		14q32.13; chr14:95552565-95623759 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DICER1

Alleles and phenotypes

All alleles(25) : Targeted(14) Gene trapped(11)
 

Mutation of this locus results in arrest of early embryonic development.

 
Human Diseases Modeled Using Mouse Dicer1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (100 annotations)

Process	angiogenesis, apoptotic process, ...
Component	axon, cytoplasm, ...
Function	ATP binding, ATP-dependent helicase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (318)    Tissues (127)    Images (50)
Theiler Stages: 2, 3, 10, 16, 18, 19, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	248
Northern blot	20
Western blot	2
RT-PCR	48

cDNA source data(166)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(175) cDNA(166) Primer pair(7) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000041415 (Evidence)
Entrez Gene	192119 (Evidence)
UniGene	21135
DFCI	TC1577504, TC1615862, TC1629974, TC1642847
DoTS	DT.101150704, DT.101307454, DT.40140525, DT.528104, DT.91352884
NIA Mouse Gene Index	U034309
EC	3.1.26.-, 3.1.26.3
PDB	3C4B, 3C4T
Consensus CDS Project	CCDS36539.1
International Mouse Knockout Project Status	Dicer1

Sequences

Length	Strain/Species
genomic	192119	NCBI Gene Model | MGI Sequence Detail	64211	C57BL/6J
transcript	NM_148948	RefSeq | MGI Sequence Detail	9851	Not Specified
polypeptide	Q8R418	UniProt | EBI | MGI Sequence Detail	1916	Not Applicable

All sequences(44) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(334 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003100	Argonaute/Dicer protein, PAZ
InterPro	IPR005034	Dicer double-stranded RNA-binding fold
InterPro	IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro	IPR001159	Double-stranded RNA-binding
InterPro	IPR014720	Double-stranded RNA-binding-like
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR011907	Ribonuclease III
InterPro	IPR000999	Ribonuclease III domain
Protein Ontology	PR:000006478	endoribonuclease Dicer

Graphical View of Protein Domain Structure

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:194523 Brady BL, et al., Requirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks. J Immunol. 2013 Apr 1;190(7):3256-66
All references(257)

Other accession IDs

MGI:1098649, MGI:1915712