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Dicer1
Gene Detail
Symbol

Name
ID
Dicer1
dicer 1, ribonuclease type III
MGI:2177178
Synonyms
1110006F08Rik, D12Ertd7e, Dicer1, mKIAA0928
Feature Type
protein coding gene
Genetic Map
Chromosome 12
54.83 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:104687742-104751952 bp, - strand
From Ensembl annotation of GRCm38

  64211 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13251  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DICER1
Gene Tree: Dicer1

Human
homologs
DICER1, dicer 1, ribonuclease type III
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23405
neXtProt AC: NX_Q9UPY3

Human Synonyms: DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2

Human Chr (Location): 14q32.13; chr14:95086228-95158010 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human DICER1

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Endonuclease-mediated(3) Gene trapped(11) Targeted(19)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutation of this locus results in arrest of early embryonic development.
 
Human Diseases Modeled in Mice Using Dicer1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Dicer1 interacts with 438 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (122 annotations)
Process anatomical structure development, angiogenesis, ...
Component axon, cytoplasm, ...
Function ATP binding, deoxyribonuclease I activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (318)    Tissues (127)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 248
Northern blot 20
Western blot 2
RT-PCR 48
cDNA source data(167)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dicer1    NEW 
Molecular
reagents
All nucleic(176) cDNA(167) Primer pair(7) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000041415 (Evidence)
Entrez Gene 192119 (Evidence)
UniGene 21135
DFCI TC1642847, TC1629974, TC1577504, TC1615862
DoTS DT.101150704, DT.528104, DT.101307454, DT.40140525, DT.91352884
NIA Mouse Gene Index U034309
EC 3.1.26.3
PDB 3C4T, 3C4B
Consensus CDS Project CCDS36539.1
International Mouse Phenotyping Consortium Status Dicer1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041415 Ensembl Gene Model | MGI Sequence Detail 64211 C57BL/6J ±  kb
transcript ENSMUST00000041987 Ensembl | MGI Sequence Detail 9851 Not Applicable 
polypeptide ENSMUSP00000043676 Ensembl | MGI Sequence Detail 1906 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(7)
Polymorphisms
SNPs within 2kb(346 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003100 Argonaute/Dicer protein, PAZ
InterPro IPR005034 Dicer double-stranded RNA-binding fold
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011907 Ribonuclease III
InterPro IPR000999 Ribonuclease III domain
Protein Ontology PR:000006478 endoribonuclease Dicer
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(314)
Disease annotation references (1)
Other
accession IDs
MGI:1098649, MGI:1915712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory