Havcr1
Gene Detail

Symbol Name ID

Havcr1 hepatitis A virus cellular receptor 1 MGI:2159680

Synonyms

KIM-1, Tim1, TIM-1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

28.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:46735080-46779578 bp, + strand From VEGA annotation of GRCm38   44499 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:77133  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Havcr1

Human homologs

Human Homolog		HAVCR1, hepatitis A virus cellular receptor 1
NCBI Gene ID		26762
neXtProt AC		NX_Q96D42
Human Synonyms		HAVCR, HAVCR-1, KIM1, KIM-1, TIM, TIM1, TIM-1, TIMD1, TIMD-1
Human Chr (Location)		5q33.2; chr5:156456531-156485970 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HAVCR1

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit normal response to S. mansoni egg challenge. Mice homozygous for an allele lacking the mucin domain display impaired regulatory B cell function and systemic autoimmunity.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	phagocytosis, engulfment
Component	cell surface, extracellular space, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(45)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(46) cDNA(45) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005506 (Evidence)
Ensembl Gene Model	ENSMUSG00000040405 (Evidence)
Entrez Gene	171283 (Evidence)
UniGene	17771
DFCI	TC1581000, TC1600372
DoTS	DT.110513662, DT.40146143, DT.97408335
NIA Mouse Gene Index	U043162
PDB	2OR8
Consensus CDS Project	CCDS24583.1, CCDS48778.1
International Mouse Knockout Project Status	Havcr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005506	VEGA Gene Model | MGI Sequence Detail	44499	C57BL/6J
transcript	OTTMUST00000012254	VEGA | MGI Sequence Detail	1892	Not Applicable
polypeptide	OTTMUSP00000005660	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(44) RefSeq(6) UniProt(3)

Polymorphisms

PCR(1) : SNPs(186 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000008453	hepatitis A virus cellular receptor 1

References

(Earliest) J:72894 McIntire JJ, et al., Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec;2(12):1109-16
(Latest) J:187793 Curtiss ML, et al., Tim-1 regulates Th2 responses in an airway hypersensitivity model. Eur J Immunol. 2012 Mar;42(3):651-61
All references(47)

Other accession IDs

MGI:2144204