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Havcr1 Gene Detail
Summary
  • Symbol
    Havcr1
  • Name
    hepatitis A virus cellular receptor 1
  • Synonyms
    KIM-1, Tim1, TIM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159680
    NCBI Gene: 171283
  • Gene Overview
    MyGene.info: HAVCR1
Location & Maps
more
  • Sequence Map
    Chr11:46735080-46779578 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44499 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 28.08 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HAVCR1, hepatitis A virus cellular receptor 1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    HAVCR1, hepatitis A virus cellular receptor 1
    Orthology source: HGNC
  • Synonyms
    CD365, HAVCR, HAVCR-1, KIM1, KIM-1, TIM, TIM1, TIM-1, TIMD1, TIMD-1
  • Links
    NCBI Gene ID: 26762
    neXtProt AC: NX_Q96D42

  • Chr Location
    5q33.2; chr5:156979480-157069527 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HAVCR1 associations

Human Disease Mouse Models
       IgE Responsiveness, Atopic; IGER   OMIM: 147050
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Havcr1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit normal response to S. mansoni egg challenge. Mice homozygous for an allele lacking the mucin domain display impaired regulatory B cell function and systemic autoimmunity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase havcr1
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005506 VEGA Gene Model | MGI Sequence Detail 44499 C57BL/6J ±  kb
transcript OTTMUST00000012254 VEGA | MGI Sequence Detail 1892 Not Applicable  
polypeptide OTTMUSP00000005660 VEGA | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    332 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 47
    cDNA 45
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144204
References
more
  • Summaries
    All 51
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:72894 McIntire JJ, et al., Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec;2(12):1109-16
  • Latest
    J:226715 Brooks CR, et al., KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation. EMBO J. 2015 Oct 1;34(19):2441-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory