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Havcr1
Gene Detail
 Symbol
Name
ID
Havcr1
hepatitis A virus cellular receptor 1
MGI:2159680
Synonyms KIM-1, Tim1, TIM-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
28.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:46735080-46779578 bp, + strand
From VEGA annotation of GRCm38

  44499 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136301  Vertebrate Homology Class
1 mouse; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Havcr1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal response to S. mansoni egg challenge. Mice homozygous for an allele lacking the mucin domain display impaired regulatory B cell function and systemic autoimmunity.
 
Interactions
Havcr1 interacts with 133 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process positive regulation of mast cell activation
Component integral component of membrane, membrane
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(45)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(45) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005506 (Evidence)
Ensembl Gene ModelENSMUSG00000040405 (Evidence)
Entrez Gene171283 (Evidence)
UniGene17771
DFCITC1581000, TC1600372
DoTSDT.110513662, DT.40146143, DT.97408335
NIA Mouse Gene IndexU043162
PDB2OR8
Consensus CDS ProjectCCDS24583.1, CCDS48778.1
International Mouse Knockout Project StatusHavcr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005506 VEGA Gene Model | MGI Sequence Detail 44499 C57BL/6J ±  kb
transcript OTTMUST00000012254 VEGA | MGI Sequence Detail 1892 Not Applicable 
polypeptide OTTMUSP00000005660 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(352 from dbSNP Build 137)    SNPs within 2kb including multiple locations(376)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000008453 hepatitis A virus cellular receptor 1
References (Earliest) J:72894 McIntire JJ, et al., Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec;2(12):1109-16
(Latest) J:210882 Nozaki Y, et al., Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice. Am J Physiol Renal Physiol. 2014 May 15;306(10):F1210-21
All references(50)
Other
accession IDs
MGI:2144204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory