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Tmprss3 Gene Detail
Summary
  • Symbol
    Tmprss3
  • Name
    transmembrane protease, serine 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155445
    NCBI Gene: 140765
Location & Maps
more
  • Sequence Map
    Chr17:31179272-31198975 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19704 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TMPRSS3, transmembrane protease, serine 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMPRSS3, transmembrane protease, serine 3
    Orthology source: HomoloGene
  • Synonyms
    DFNB10, DFNB8, ECHOS1, TADG12
  • Links
    NCBI Gene ID: 64699
    neXtProt AC: NX_P57727

  • Chr Location
    21q22.3; chr21:42371887-42396846 (-)  GRCh38.p2

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Tmprss3
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit early onset deafness and disrupted vestibular function associated with hair cell degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020097 VEGA Gene Model | MGI Sequence Detail 19704 C57BL/6J ±  kb
transcript OTTMUST00000047792 VEGA | MGI Sequence Detail 2872 Not Applicable  
polypeptide OTTMUSP00000021726 VEGA | MGI Sequence Detail 475 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    264 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016457 transmembrane protease serine 3
  • EC
  • InterPro Domains
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR001314 Peptidase S1A, chymotrypsin-type
    IPR009003 Peptidase S1, PA clan
    IPR018114 Peptidase S1, trypsin family, active site
    IPR001254 Serine proteases, trypsin domain
    IPR001190 SRCR domain
    IPR017448 SRCR-like domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 4
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:69673 Davisson MT, et al., Evolutionary breakpoints on human chromosome 21. Genomics. 2001 Nov;78(1/2):99-106
  • Latest
    J:193850 Molina L, et al., Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Hum Mol Genet. 2013 Apr 1;22(7):1289-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory