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Tmprss3
Gene Detail
Symbol

Name
ID
Tmprss3
transmembrane protease, serine 3
MGI:2155445
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:31179272-31198975 bp, - strand
From VEGA annotation of GRCm38

  19704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56985  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TMPRSS3
Protein SuperFamily: TMPRSS2-like transmembrane serine protease
Gene Tree: Tmprss3

Human
homologs
TMPRSS3, transmembrane protease, serine 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64699
neXtProt AC: NX_P57727

Human Synonyms: DFNB10, DFNB8, ECHOS1, TADG12

Human Chr (Location): 21q22.3; chr21:42371887-42396846 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Genomic Mutations involving Tmprss3 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit early onset deafness and disrupted vestibular function associated with hair cell degeneration.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Tmprss3 interacts with 178 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular sodium ion homeostasis, proteolysis, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (70)    Tissues (66)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 22
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(4) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000020097 (Evidence)
Ensembl Gene Model ENSMUSG00000024034 (Evidence)
Entrez Gene 140765 (Evidence)
UniGene 214638
DFCI TC1590733
DoTS DT.97333523
EC 3.4.21.-
Consensus CDS Project CCDS37547.1, CCDS50053.1
International Mouse Phenotyping Consortium Status Tmprss3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020097 VEGA Gene Model | MGI Sequence Detail 19704 C57BL/6J ±  kb
transcript OTTMUST00000047792 VEGA | MGI Sequence Detail 2872 Not Applicable 
polypeptide OTTMUSP00000021726 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(264 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000016457 transmembrane protease serine 3
References
(Earliest) J:69673 Davisson MT, et al., Evolutionary breakpoints on human chromosome 21. Genomics. 2001 Nov;78(1/2):99-106
(Latest) J:193850 Molina L, et al., Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Hum Mol Genet. 2013 Apr 1;22(7):1289-99
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory