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Tmprss3
Gene Detail
Symbol

Name
ID
Tmprss3
transmembrane protease, serine 3
MGI:2155445
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:31179272-31198975 bp, - strand
From VEGA annotation of GRCm38

  19704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56985  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: TMPRSS2-like transmembrane serine protease
Gene Tree: Tmprss3

Human
homologs
Human Homolog TMPRSS3, transmembrane protease, serine 3
NCBI Gene ID 64699
neXtProt AC  NX_P57727
Human Synonyms  DFNB10, DFNB8, ECHOS1, TADG12
Human Chr (Location)  21q22.3; chr21:42371887-42396846 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Genomic Mutations involving Tmprss3 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit early onset deafness and disrupted vestibular function associated with hair cell degeneration.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tmprss3 interacts with 178 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular sodium ion homeostasis, proteolysis, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (70)    Tissues (66)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 22
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(4) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020097 (Evidence)
Ensembl Gene ModelENSMUSG00000024034 (Evidence)
Entrez Gene140765 (Evidence)
UniGene214638
DFCITC1590733
DoTSDT.97333523
EC3.4.21.-
Consensus CDS ProjectCCDS37547.1, CCDS50053.1
International Mouse Knockout Project StatusTmprss3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020097 VEGA Gene Model | MGI Sequence Detail 19704 C57BL/6J ±  kb
transcript OTTMUST00000047792 VEGA | MGI Sequence Detail 2872 Not Applicable 
polypeptide OTTMUSP00000021726 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(264 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000016457 transmembrane protease serine 3
References
(Earliest) J:69673 Davisson MT, et al., Evolutionary breakpoints on human chromosome 21. Genomics. 2001 Nov;78(1/2):99-106
(Latest) J:193850 Molina L, et al., Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Hum Mol Genet. 2013 Apr 1;22(7):1289-99
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory