Dmbx1
Gene Detail

Symbol Name ID

Dmbx1 diencephalon/mesencephalon homeobox 1 MGI:2153518

Synonyms

Atx, Cdmx, Dmbx1, Mbx, Otx3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

53.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:115914544-115939926 bp, - strand From VEGA annotation of GRCm38   25383 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dmbx1

Human homologs

Human Homolog		DMBX1, diencephalon/mesencephalon homeobox 1
NCBI Gene ID		127343
neXtProt AC		NX_Q8NFW5
Human Synonyms		MBX, OTX3, PAXB
Human Chr (Location)		1p33; chr1:46972668-46979898 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(8) Gene trapped(1)
 

Mice homozygous for one null allele display partial postnatal lethality, impaired suckling and postnatal growth, and reduced female fertility. When raised in isolation, mice homozygous for another null allele exhibit decreased body weight, decreased food consumption, and small adipocytes.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	adult feeding behavior, adult locomotory behavior, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (421)    Tissues (261)    Images (81)
Theiler Stages: 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	390
Northern blot	3
RT-PCR	28

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(12) Primer pair(5) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000008711 (Evidence)
Ensembl Gene Model	ENSMUSG00000028707 (Evidence)
Entrez Gene	140477 (Evidence)
DFCI	TC1591156, TC1599233, TC1632820
DoTS	DT.101362901, DT.94182511
Consensus CDS Project	CCDS18500.1
International Mouse Knockout Project Status	Dmbx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008711	VEGA Gene Model | MGI Sequence Detail	25383	C57BL/6J
transcript	OTTMUST00000019784	VEGA | MGI Sequence Detail	4592	Not Applicable
polypeptide	OTTMUSP00000009064	VEGA | MGI Sequence Detail	376	Not Applicable

All sequences(38) RefSeq(4) UniProt(2)

Polymorphisms

PCR(1) : SNPs(182 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003654	OAR domain
Protein Ontology	PR:000006535	diencephalon/mesencephalon homeobox protein 1

References

(Earliest) J:72725 Martinez-Barbera JP, et al., Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development. 2001 Dec;128(23):4789-800
(Latest) J:168654 Chung YC, et al., Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
All references(53)