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Dmbx1 Gene Detail
Summary
  • Symbol
    Dmbx1
  • Name
    diencephalon/mesencephalon homeobox 1
  • Synonyms
    Atx, Cdmx, Dmbx1, Mbx, Otx3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153518
    NCBI Gene: 140477
Location & Maps
more
  • Sequence Map
    Chr4:115915119-115939926 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24808 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DMBX1, diencephalon/mesencephalon homeobox 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DMBX1, diencephalon/mesencephalon homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MBX, OTX3, PAXB
  • Links
    NCBI Gene ID: 127343
    neXtProt AC: NX_Q8NFW5

  • Chr Location
    1p33; chr1:46489837-46514226 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 6 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    4 involving Dmbx1
  • Incidental Mutations
Mice homozygous for one null allele display partial postnatal lethality, impaired suckling and postnatal growth, and reduced female fertility. When raised in isolation, mice homozygous for another null allele exhibit decreased body weight, decreased food consumption, and small adipocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008711 VEGA Gene Model | MGI Sequence Detail 24808 C57BL/6J ±  kb
transcript OTTMUST00000019783 VEGA | MGI Sequence Detail 5799 Not Applicable  
polypeptide OTTMUSP00000009063 VEGA | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    200 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 12
    Primer pair 5
    Other 5

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 29
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:72725 Martinez-Barbera JP, et al., Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development. 2001 Dec;128(23):4789-800
  • Latest
    J:223223 Wu Q, et al., SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice. Development. 2015 Feb 1;142(3):575-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory