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Dmbx1
Gene Detail
Symbol

Name
ID
Dmbx1
diencephalon/mesencephalon homeobox 1
MGI:2153518
Synonyms
Atx, Cdmx, Dmbx1, Mbx, Otx3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
53.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:115915119-115939926 bp, - strand
From VEGA annotation of GRCm38

  24808 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dmbx1

Human
homologs
Human Homolog DMBX1, diencephalon/mesencephalon homeobox 1
NCBI Gene ID 127343
neXtProt AC  NX_Q8NFW5
Human Synonyms  MBX, OTX3, PAXB
Human Chr (Location)  1p33; chr1:46489870-46514226 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele display partial postnatal lethality, impaired suckling and postnatal growth, and reduced female fertility. When raised in isolation, mice homozygous for another null allele exhibit decreased body weight, decreased food consumption, and small adipocytes.
 
Interactions
Dmbx1 interacts with 309 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process adult feeding behavior, adult locomotory behavior, ...
Component nucleus, transcription factor complex
Function DNA binding, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (421)    Tissues (266)    Images (85)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 397
Northern blot 3
RT-PCR 21
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(12) Primer pair(5) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008711 (Evidence)
Ensembl Gene ModelENSMUSG00000028707 (Evidence)
Entrez Gene140477 (Evidence)
DFCITC1599233, TC1591156, TC1632820
DoTSDT.101362901, DT.94182511
Consensus CDS ProjectCCDS18500.1
International Mouse Knockout Project StatusDmbx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008711 VEGA Gene Model | MGI Sequence Detail 24808 C57BL/6J ±  kb
transcript OTTMUST00000019783 VEGA | MGI Sequence Detail 5799 Not Applicable 
polypeptide OTTMUSP00000009063 VEGA | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(202 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000006535 diencephalon/mesencephalon homeobox protein 1
References
(Earliest) J:72725 Martinez-Barbera JP, et al., Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development. 2001 Dec;128(23):4789-800
(Latest) J:168654 Chung YC, et al., Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory