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Trrap
Gene Detail
Symbol

Name
ID
Trrap
transformation/transcription domain-associated protein
MGI:2153272
Synonyms
transactivation/transformation-domain associated protein
Feature Type
protein coding gene
Genetic Map
Chromosome 5
84.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:144768092-144859778 bp, + strand
From VEGA annotation of GRCm38

  91687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39246  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRRAP
Gene Tree: Trrap

Human
homologs
TRRAP, transformation/transcription domain-associated protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8295
neXtProt AC: NX_Q9Y4A5

Human Synonyms: PAF350/400, PAF400, STAF40, Tra1, TR-AP

Human Chr (Location): 7q21.2-q22.1; chr7:98878490-99013243 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous embryos die prior to E3.5 and exhibit embryonic and extraembryonic tissue disorganization. Mitotic abnormalities were also noted in homozygous cells.
 
Interactions
Trrap interacts with 272 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process chromatin modification, DNA repair, ...
Component Golgi apparatus, histone acetyltransferase complex, ...
Function chromatin binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (74)    Tissues (14)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
cDNA source data(194)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trrap ; ZFIN trrap    NEW 
Molecular
reagents
All nucleic(195) cDNA(195)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017164 (Evidence)
Ensembl Gene Model ENSMUSG00000045482 (Evidence)
Entrez Gene 100683 (Evidence)
UniGene 273570
DFCI TC1606209, TC1576354, TC1708096, TC1612285, TC1743856
DoTS DT.40186126, DT.103570749, DT.97340408, DT.94158904, DT.94158903, DT.91392198
NIA Mouse Gene Index U006424
Consensus CDS Project CCDS39379.1
International Mouse Phenotyping Consortium Status Trrap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017164 VEGA Gene Model | MGI Sequence Detail 91687 C57BL/6J ±  kb
transcript OTTMUST00000041552 VEGA | MGI Sequence Detail 12456 Not Applicable 
polypeptide OTTMUSP00000018668 VEGA | MGI Sequence Detail 3858 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(34) UniProt(8)
Polymorphisms
SNPs within 2kb(485 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR014009 PIK-related kinase
InterPro IPR003151 PIK-related kinase, FAT
InterPro IPR003152 PIK-related kinase, FATC
InterPro IPR011009 Protein kinase-like domain
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000016706 transformation/transcription domain-associated protein
References
(Earliest) J:71950 Herceg Z, et al., Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet. 2001 Oct;29(2):206-11
(Latest) J:196318 Sawan C, et al., Histone acetyltransferase cofactor trrap maintains self-renewal and restricts differentiation of embryonic stem cells. Stem Cells. 2013 May;31(5):979-91
All references(39)
Other
accession IDs
MGI:2140918

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory