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Kcnn3 Gene Detail
Summary
  • Symbol
    Kcnn3
  • Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
  • Synonyms
    SK3, small conductance calcium-activated potassium channel 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153183
    NCBI Gene: 140493
  • Gene Overview
    MyGene.info: KCNN3
Location & Maps
more
  • Sequence Map
    Chr3:89520164-89675132 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      154969 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.16 cM, cytoband F2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KCNN3, potassium calcium-activated channel subfamily N member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KCNN3, potassium calcium-activated channel subfamily N member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hSK3, KCa2.3, SK3, SKCA3
  • Links
    NCBI Gene ID: 3782
    neXtProt AC: NX_Q9UGI6

  • Chr Location
    1q21.3; chr1:154697462-154870278 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Kcnn3
  • Incidental Mutations
Mice homozygous for an insertion of a tetracycline-regulated gene switch display no overt phenotype when expression is abolished by doxycycline treatment; in contrast, untreated homozygotes show abnormal respiratory responses to hypoxia, impaired parturition, and pregnancy-related premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027213 VEGA Gene Model | MGI Sequence Detail 154969 C57BL/6J ±  kb
transcript OTTMUST00000067297 VEGA | MGI Sequence Detail 2884 Not Applicable  
polypeptide OTTMUSP00000033832 VEGA | MGI Sequence Detail 732 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    878 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000714 small conductance calcium-activated potassium channel protein 3
  • InterPro Domains
    IPR004178 Calmodulin-binding domain
    IPR015449 Potassium channel, calcium-activated, SK
    IPR013099 Potassium channel domain
Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 56
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:95064 Bond CT, et al., Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. Science. 2000 Sep 15;289(5486):1942-6
  • Latest
    J:233007 Yap FC, et al., Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure. Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1151-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory