Rpl31 MGI Mouse Gene Detail - MGI:2149632

Symbol

Rpl31
Name

ribosomal protein L31
Synonyms

Dts

Feature Type

protein coding gene
IDs

MGI:2149632
NCBI Gene: 114641
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:39406987-39410992 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 18.30 cM
Mapping Data

2 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

31

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2149632	protein coding gene	Chr1:39406923-39410992 (+)
129S1/SvImJ	no annotation
A/J	ENSMUSG00195018031	protein coding gene	Chr15:87720733-87722655 (-)
A/J	ENSMUSG00195041322	protein coding gene	Chr1:36663543-36667598 (+)
A/J	ENSMUSG00195039455	protein coding gene	Chr1:126370136-126370565 (-)
AKR/J	ENSMUSG00220008296	protein coding gene	Chr1:36664037-36668110 (+)
AKR/J	ENSMUSG00220044039	protein coding gene	Chr1:126236200-126236969 (-)
BALB/cJ	ENSMUSG00180011279	protein coding gene	Chr1:36745704-36749773 (+)
BALB/cJ	ENSMUSG00180033972	protein coding gene	Chr1:126953823-126954616 (-)
C3H/HeJ	ENSMUSG00175026339	protein coding gene	Chr15:87907214-87909136 (-)
C3H/HeJ	ENSMUSG00175001159	protein coding gene	Chr1:36666618-36670673 (+)
C3H/HeJ	ENSMUSG00175037479	protein coding gene	Chr1:126635619-126636048 (-)
C57BL/6NJ	ENSMUSG00215044685	protein coding gene	Chr1:126650937-126651693 (-)
C57BL/6NJ	ENSMUSG00215023407	protein coding gene	Chr1:36720821-36724890 (+)
C57BL/6NJ	ENSMUSG00215019922	protein coding gene	Chr15:87683335-87685258 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014069	protein coding gene	Chr1:33997346-34001573 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210013049	protein coding gene	Chr15:87676644-87678566 (-)
CBA/J	ENSMUSG00210027904	protein coding gene	Chr1:126531874-126532303 (-)
CBA/J	ENSMUSG00210005430	protein coding gene	Chr1:36480636-36484708 (+)
DBA/2J	ENSMUSG00185001719	protein coding gene	Chr1:130898238-130898796 (-)
DBA/2J	ENSMUSG00185009501	protein coding gene	Chr1:37577495-37581564 (+)
FVB/NJ	ENSMUSG00205020039	protein coding gene	Chr1:36683108-36687177 (+)
FVB/NJ	ENSMUSG00205031702	protein coding gene	Chr15:87449028-87450951 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230021801	protein coding gene	Chr1:37618283-37622356 (+)
LP/J	ENSMUSG00230000812	protein coding gene	Chr1:130477918-130478317 (-)
LP/J	ENSMUSG00230043258	protein coding gene	Chr15:91047201-91049123 (-)
NOD/ShiLtJ	ENSMUSG00190025780	protein coding gene	Chr15:87721823-87723745 (-)
NOD/ShiLtJ	ENSMUSG00190024073	protein coding gene	Chr1:36692067-36696136 (+)
NOD/ShiLtJ	ENSMUSG00190026795	protein coding gene	Chr1:126535164-126535593 (-)
NZO/HlLtJ	ENSMUSG00225014148	protein coding gene	Chr1:40879397-40883465 (+)
NZO/HlLtJ	ENSMUSG00225018025	protein coding gene	Chr1:134214614-134215013 (-)
NZO/HlLtJ	ENSMUSG00225047993	protein coding gene	Chr15:91364687-91365778 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

RPL31, ribosomal protein L31

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL31, ribosomal protein L31
Synonyms

eL31, L31
Links

HGNC:10334

NCBI Gene ID: 6160

UniProt: P62899
Chr Location

2q11.2; chr2:101002229-101024032 (+) GRCh38

MGI Vertebrate Homology

Rpl31 stringent orthology
1 human;1 mouse;4 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL31
Gene Tree

Rpl31

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Gene trapped

2
Spontaneous

2
Genomic Mutations

1 involving Rpl31
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Carriers of dominant spontaneous mutations have a shortened, kinked tail with variable expessivity in the tail length and number of kinks.

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All GO Annotations

33
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

609
Tissues

7
cDNA Data

18
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl31

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All Sequences

80
RefSeq

6
UniProt

5
CCDS

CCDS14904.1

Ensembl

ENSMUSG00000073702 (Evidence)
NCBI Gene

114641

			Length	Strain/Species	Flank
genomic	114641	NCBI Gene Model \| MGI Sequence Detail	4006	C57BL/6J	± kb
transcript	NM_001252218	RefSeq \| MGI Sequence Detail	1199	C57BL/6
polypeptide	P62900	UniProt \| EBI \| MGI Sequence Detail	125	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014214 large ribosomal subunit protein eL31

(term hierarchy)
PDB

6SWA, 7CPU, 7CPV, 7LS1, 7LS2, 9H4N, 9QOH, 9QQL, 9QQP, 9QSA, 9QWT
InterPro Domains

IPR000054 Large ribosomal subunit protein eL31

IPR020052 Large ribosomal subunit protein eL31, conserved site

IPR023621 Large ribosomal subunit protein eL31 domain superfamily
GlyGen

P62900 1 site, 1 O-linked glycan (1 site)

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 15

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MGI:4456871

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 6
Earliest

J:60564 Cabibbo A, et al., ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem. 2000 Feb 18;275(7):4827-33
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rpl31:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6375	Chr1:39406897-39406929 (+)	-74 bp
Tssr6376	Chr1:39406955-39406966 (+)	-26 bp
Tssr6377	Chr1:39406981-39407012 (+)	10 bp
Tssr6378	Chr1:39407183-39407209 (+)	209 bp
Tssr6379	Chr1:39408265-39408279 (+)	1,285 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24