About   Help   FAQ
Aipl1 Gene Detail
Summary
  • Symbol
    Aipl1
  • Name
    aryl hydrocarbon receptor-interacting protein-like 1
  • Synonyms
    A930007I01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148800
    NCBI Gene: 114230
  • Gene Overview
    MyGene.info: AIPL1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72027963-72037509 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148800
protein coding gene Chr11:72027963-72038897 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018627
protein coding gene Chr11:72627033-72636563 (-)
A/J MGP_AJ_G0018595
protein coding gene Chr11:69919775-69929319 (-)
AKR/J MGP_AKRJ_G0018564
protein coding gene Chr11:72036748-72046294 (-)
BALB/cJ MGP_BALBcJ_G0018567
protein coding gene Chr11:70208954-70218499 (-)
C3H/HeJ MGP_C3HHeJ_G0018380
protein coding gene Chr11:72004552-72014098 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019018
protein coding gene Chr11:74819753-74829299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016661
protein coding gene Chr11:66760651-66770374 (-)
CAST/EiJ MGP_CASTEiJ_G0017935
protein coding gene Chr11:72378300-72392604 (-)
CBA/J MGP_CBAJ_G0018352
protein coding gene Chr11:78144585-78154126 (-)
DBA/2J MGP_DBA2J_G0018461
protein coding gene Chr11:69568213-69577764 (-)
FVB/NJ MGP_FVBNJ_G0018452
protein coding gene Chr11:69087140-69096684 (-)
LP/J MGP_LPJ_G0018532
protein coding gene Chr11:73147577-73159168 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018475
protein coding gene Chr11:78731181-78740725 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019060
protein coding gene Chr11:72252760-72262305 (-)
PWK/PhJ MGP_PWKPhJ_G0017708
protein coding gene Chr11:70176258-70185873 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017498
protein coding gene Chr11:71957328-71968270 (-)
WSB/EiJ MGP_WSBEiJ_G0017989
protein coding gene Chr11:71990052-71999721 (-)



Homology
more
  • Human Ortholog
    AIPL1, aryl hydrocarbon receptor interacting protein like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AIPL1, aryl hydrocarbon receptor interacting protein like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIPL2, LCA4
  • Links
    NCBI Gene ID: 23746
    neXtProt AC: NX_Q9NZN9
    UniProt: Q9NZN9

  • Chr Location
    17p13.2; chr17:6423737-6435199 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22806
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AIPL1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Aipl1 mouse models; 2 with human AIPL1 associations

Human Disease Mouse Models
      
IDs
View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 5 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    3 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Aipl1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Homozygous null mice display complete retinal degeneration and a lack of electroretinographic responses. Homozygous hypomorphic mutants display less severe retinal degeneration and impaired electroretinographic responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040554 Ensembl Gene Model | MGI Sequence Detail 9547 C57BL/6J ±  kb
transcript ENSMUST00000048207 Ensembl | MGI Sequence Detail 2309 Not Applicable  
polypeptide ENSMUSP00000036279 Ensembl | MGI Sequence Detail 328 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 3
Other
Accession IDs
less
MGI:1925019
References
more
  • Summaries
    All 50
    Diseases 5
    Gene Ontology 9
    Phenotypes 24
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:243745 Krebs MP, et al., Mouse models of human ocular disease for translational research. PLoS One. 2017;12(8):e0183837

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory