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Aipl1
Gene Detail
Symbol

Name
ID
Aipl1
aryl hydrocarbon receptor-interacting protein-like 1
MGI:2148800
Synonyms
A930007I01Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
43.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:72027963-72037509 bp, - strand
From VEGA annotation of GRCm38

  9547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22806  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AIPL1
Gene Tree: Aipl1

Human
homologs
AIPL1, aryl hydrocarbon receptor interacting protein-like 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23746
neXtProt AC: NX_Q9NZN9

Human Synonyms: AIPL2, LCA4

Human Chr (Location): 17p13.1; chr17:6423737-6435199 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human AIPL1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
Genomic Mutations involving Aipl1 (1)
Incidental mutations (data from APF , CvDC )
 
Homozygous null mice display complete retinal degeneration and a lack of electroretinographic responses. Homozygous hypomorphic mutants display less severe retinal degeneration and impaired electroretinographic responses.
 
Human Diseases Modeled in Mice Using Aipl1 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(3)
Interactions
Aipl1 interacts with 214 markers (Mir1b, Mir18b, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of apoptotic process, phototransduction, visible light, ...
Component cytoplasm, nucleus, ...
Function farnesylated protein binding
External Resources: FuncBase
Expression
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aipl1    NEW 
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006096 (Evidence)
Ensembl Gene Model ENSMUSG00000040554 (Evidence)
Entrez Gene 114230 (Evidence)
UniGene 95707
DFCI TC1614228, TC1585962
DoTS DT.87035345, DT.94292970
NIA Mouse Gene Index U033020
Consensus CDS Project CCDS24976.1
International Mouse Phenotyping Consortium Status Aipl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006096 VEGA Gene Model | MGI Sequence Detail 9547 C57BL/6J ±  kb
transcript OTTMUST00000013772 VEGA | MGI Sequence Detail 2309 Not Applicable 
polypeptide OTTMUSP00000006382 VEGA | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023114 Elongated TPR repeat-containing domain
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000003876 aryl-hydrocarbon-interacting protein-like 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218096 Ku CA, et al., Viral-mediated vision rescue of a novel AIPL1 cone-rod dystrophy model. Hum Mol Genet. 2015 Feb 1;24(3):670-84
All references(36)
Disease annotation references (3)
Other
accession IDs
MGI:1925019

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory