Acaa1a
Gene Detail

Symbol Name ID

Acaa1a acetyl-Coenzyme A acyltransferase 1A MGI:2148491

Synonyms

Acaa1, D9Ertd25e, MGC:7090, peroxisomal 3-ketoacyl-CoA thiolase, PTL, thiolase A

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.33 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:119339676-119350299 bp, + strand From VEGA annotation of GRCm38   10624 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37497  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acaa1a

Human homologs

Human Homolog		ACAA1, acetyl-CoA acyltransferase 1
NCBI Gene ID		30
neXtProt AC		NX_P09110
Human Synonyms		ACAA, PTHIO, THIO
Human Chr (Location)		3p22.2; chr3:38164201-38178733 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	bile acid metabolic process, fatty acid beta-oxidation, ...
Component	intracellular membrane-bounded organelle, mitochondrion, ...
Function	acetyl-CoA C-acetyltransferase activity, acetyl-CoA C-acyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (220)    Tissues (115)    Images (42)
Theiler Stages: 15, 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	190
Northern blot	15
Western blot	15

cDNA source data(192)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(195) cDNA(194) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000042191 (Evidence)
Ensembl Gene Model	ENSMUSG00000036138 (Evidence)
Entrez Gene	113868 (Evidence)
UniGene	205266
NIA Mouse Gene Index	U011135
EC	2.3.1.16
Consensus CDS Project	CCDS23613.1
International Mouse Knockout Project Status	Acaa1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042191	VEGA Gene Model | MGI Sequence Detail	10624	C57BL/6J
transcript	OTTMUST00000110753	VEGA | MGI Sequence Detail	1762	Not Applicable
polypeptide	OTTMUSP00000061838	VEGA | MGI Sequence Detail	424	Not Applicable

All sequences(58) RefSeq(2) UniProt(9)

Polymorphisms

SNPs(58 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002155	Thiolase
InterPro	IPR020610	Thiolase, active site
InterPro	IPR020615	Thiolase, acyl-enzyme intermediate active site
InterPro	IPR020613	Thiolase, conserved site
InterPro	IPR020617	Thiolase, C-terminal
InterPro	IPR016039	Thiolase-like
InterPro	IPR016038	Thiolase-like, subgroup
InterPro	IPR020616	Thiolase, N-terminal
Protein Ontology	PR:000004540	3-ketoacyl-CoA thiolase A, peroxisomal

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(43)

Other accession IDs

MGI:1098606