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Yars
Gene Detail
Symbol

Name
ID
Yars
tyrosyl-tRNA synthetase
MGI:2147627
Feature Type
protein coding gene
Genetic Map
Chromosome 4
63.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:129189760-129219607 bp, + strand
From VEGA annotation of GRCm38

  29848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine tRNA ligase, archaeal/eukaryotic types
Gene Tree: Yars

Human
homologs
Human Homolog YARS, tyrosyl-tRNA synthetase
NCBI Gene ID 8565
neXtProt AC  NX_P54577
Human Synonyms  CMTDIC, TYRRS, YRS, YTS
Human Chr (Location)  1p35.1; chr1:32775239-32818032 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human YARS
Mutations,
alleles, and
phenotypes
All mutations/alleles(73) : Gene trapped(70) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Yars interacts with 134 markers (Mir1b, Mir22, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process translation, tRNA aminoacylation for protein translation, ...
Component cytoplasm, cytosol, ...
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (108)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(155)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(156) cDNA(155) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009617 (Evidence)
Ensembl Gene ModelENSMUSG00000028811 (Evidence)
Entrez Gene107271 (Evidence)
UniGene145488
DFCITC1605193, TC1573480, TC1772859
NIA Mouse Gene IndexU004860
EC6.1.1.1
Consensus CDS ProjectCCDS18685.2
International Mouse Knockout Project StatusYars
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009617 VEGA Gene Model | MGI Sequence Detail 29848 C57BL/6J ±  kb
transcript OTTMUST00000022122 VEGA | MGI Sequence Detail 2909 Not Applicable 
polypeptide OTTMUSP00000010084 VEGA | MGI Sequence Detail 564 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(5) UniProt(5)
Polymorphisms
SNPs within 2kb(394 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002305 Aminoacyl-tRNA synthetase, class Ic
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
InterPro IPR002547 tRNA-binding domain
InterPro IPR002307 Tyrosine-tRNA ligase
Protein Ontology PR:000017523 tyrosine--tRNA ligase, cytoplasmic
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(43)
Other
accession IDs
MGI:2140444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory