About   Help   FAQ
Ffar4
Gene Detail
Symbol

Name
ID
Ffar4
free fatty acid receptor 4
MGI:2147577
Synonyms
Gpr120, Gpr129, O3far1, Pgr4
Feature Type
protein coding gene
Genetic Map
Chromosome 19
32.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:38097079-38114263 bp, + strand
From NCBI annotation of GRCm38

  17185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: FFAR4
Protein SuperFamily: G protein-coupled receptor 120
Gene Tree: Ffar4

Human
homologs
FFAR4, free fatty acid receptor 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 338557
neXtProt AC: NX_Q5NUL3

Human Synonyms: BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4

Human Chr (Location): 10q23.33; chr10:93566204-93590072 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(4) Targeted(10)
Incidental mutations (data from APF )
 
Mice homozygous for a null mutation display diminished preference for and taste nerve response to fatty acids. Mice homozygous for a different knock-out allele exhibit increased susceptibility to diet-induced obesity.
 
Interactions
Ffar4 interacts with 42 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000054200 (Evidence)
Entrez Gene 107221 (Evidence)
UniGene 35288
DFCI TC1584303
DoTS DT.480882
NIA Mouse Gene Index U100866
Consensus CDS Project CCDS29783.1
International Mouse Phenotyping Consortium Status Ffar4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 107221 NCBI Gene Model | MGI Sequence Detail 17185 C57BL/6J ±  kb
transcript NM_181748 RefSeq | MGI Sequence Detail 1393 C57BL/6 
polypeptide Q7TMA4 UniProt | EBI | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001417 free fatty acid receptor 4
Graphical View of Protein Domain Structure
References
(Earliest) J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
(Latest) J:221505 Iwasaki K, et al., Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion. Endocrinology. 2015 Mar;156(3):837-46
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory