Ffar4
Gene Detail

Symbol Name ID

Ffar4 free fatty acid receptor 4 MGI:2147577

Synonyms

Gpr120, Gpr129, O3far1, Pgr4

Feature Type

protein coding gene

Genetic Map

Chromosome 19

32.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:38097079-38114263 bp, + strand From NCBI annotation of GRCm38   17185 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:18769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: G protein-coupled receptor 120
Gene Tree: Ffar4

Human homologs

Human Homolog		FFAR4, free fatty acid receptor 4
NCBI Gene ID		338557
neXtProt AC		NX_Q5NUL3
Human Synonyms		BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4
Human Chr (Location)		10q23.33; chr10:95326422-95349829 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(7) Gene trapped(4)
 

Mice homozygous for a null mutation display diminished preference for and taste nerve response to fatty acids. Mice homozygous for a different knock-out allele exhibit increased susceptibility to diet-induced obesity.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	G-protein coupled receptor signaling pathway, hormone secretion, ...
Component	endocytic vesicle, integral to membrane, ...
Function	fatty acid binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000054200 (Evidence)
Entrez Gene	107221 (Evidence)
UniGene	35288
DFCI	TC1584303
DoTS	DT.480882
NIA Mouse Gene Index	U100866
Consensus CDS Project	CCDS29783.1
International Mouse Knockout Project Status	Ffar4

Sequences

Length	Strain/Species
genomic	107221	NCBI Gene Model | MGI Sequence Detail	17185	C57BL/6J
transcript	NM_181748	RefSeq | MGI Sequence Detail	1393	C57BL/6
polypeptide	Q7TMA4	UniProt | EBI | MGI Sequence Detail	361	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(48 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001417	G-protein coupled receptor 120

Graphical View of Protein Domain Structure

References

(Earliest) J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
(Latest) J:182599 Ichimura A, et al., Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012 Mar 15;483(7389):350-4
All references(39)