About   Help   FAQ
Pkdcc
Gene Detail
Symbol

Name
ID
Pkdcc
protein kinase domain containing, cytoplasmic
MGI:2147077
Synonyms
Adtk1, ESTM17, MAd1, Vlk
Feature Type
protein coding gene
Genetic Map
Chromosome 17
52.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:83215292-83225070 bp, + strand
From VEGA annotation of GRCm38

  9779 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18932  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pkdcc

Human
homologs
Human Homolog PKDCC, protein kinase domain containing, cytoplasmic
NCBI Gene ID 91461
neXtProt AC  NX_Q504Y2
Human Synonyms  SGK493, Vlk
Human Chr (Location)  2p21; chr2:42048021-42058528 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die on postnatal day P0, apparently due to ineffective respiration. They exhibit shortening of all the long bones of the fore- and hindlimbs, cleft palate, sternal dysraphia and deficient mineralization or other anomalies of multiple bones throughout the body.
 
Interactions
Pkdcc interacts with 153 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process bone mineralization, cell differentiation, ...
Component extracellular region, Golgi apparatus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (55)    Tissues (34)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
Northern blot 20
RT-PCR 2
cDNA source data(60)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(61) cDNA(60) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035220 (Evidence)
Ensembl Gene ModelENSMUSG00000024247 (Evidence)
Entrez Gene106522 (Evidence)
UniGene311974
DFCITC1577229, TC1755789
DoTSDT.40149443, DT.110554602, DT.97388441, DT.101363281, DT.94178862
NIA Mouse Gene IndexU040828
EC2.7.10.2
Consensus CDS ProjectCCDS28994.2
International Mouse Knockout Project StatusPkdcc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035220 VEGA Gene Model | MGI Sequence Detail 9779 C57BL/6J ±  kb
transcript OTTMUST00000089736 VEGA | MGI Sequence Detail 2446 Not Applicable 
polypeptide OTTMUSP00000049074 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR022049 Uncharacterised protein family FAM69
Protein Ontology PR:000014795 protein kinase-like protein SgK493
References
(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:214801 Bordoli MR, et al., A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28;158(5):1033-44
All references(38)
Other
accession IDs
MGD-MRK-28126, MGI:104832, MGI:2146795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory