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P3h2
Gene Detail
Symbol

Name
ID
P3h2
prolyl 3-hydroxylase 2
MGI:2146663
Synonyms
Leprel1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
17.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:25959288-26105784 bp, - strand
From VEGA annotation of GRCm38

  146497 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: P3h2

Human
homologs
Human Homolog LEPREL1, leprecan-like 1
NCBI Gene ID 55214
neXtProt AC  NX_Q8IVL5
Human Synonyms  MCVD, MLAT4, P3H2
Human Chr (Location)  3q28; chr3:189956728-190122437 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LEPREL1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality between E8.5 and E12.5 with maternal platelets aggregate around the ectoplacental cone.
 
Interactions
P3h2 interacts with 162 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process collagen metabolic process, negative regulation of cell proliferation, ...
Component basement membrane, endoplasmic reticulum, ...
Function dioxygenase activity, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (166)    Tissues (93)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
Northern blot 5
RT-PCR 18
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034730 (Evidence)
Ensembl Gene ModelENSMUSG00000038168 (Evidence)
Entrez Gene210530 (Evidence)
NIA Mouse Gene IndexU036933
EC1.14.11.7
Consensus CDS ProjectCCDS28086.1
International Mouse Knockout Project StatusP3h2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034730 VEGA Gene Model | MGI Sequence Detail 146497 C57BL/6J ±  kb
transcript OTTMUST00000088247 VEGA | MGI Sequence Detail 3283 Not Applicable 
polypeptide OTTMUSP00000048079 VEGA | MGI Sequence Detail 703 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(1073 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000009760 prolyl 3-hydroxylase 2
References
(Earliest) J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
(Latest) J:206377 Pokidysheva E, et al., Biological role of prolyl 3-hydroxylation in type IV collagen. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):161-6
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory