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Srl
Gene Detail
Symbol

Name
ID
Srl
sarcalumenin
MGI:2146620
Synonyms
9830004M20Rik, sar, sarcalumenin
Feature Type
protein coding gene
Genetic Map
Chromosome 16
2.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:4480216-4541816 bp, - strand
From VEGA annotation of GRCm38

  61601 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45500  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Srl

Human
homologs
Human Homolog SRL, sarcalumenin
NCBI Gene ID 6345
neXtProt AC  NX_Q86TD4
Human Chr (Location)  16p13.3; chr16:4189374-4242080 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(32) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit impaired calcium store functions in skeletal and cardiac muscle cells resulting in slow contraction and relaxation phases. Muscle also exhibits enhanced resistance to fatigue.
 
Phenotype Images(1)
Interactions
Srl interacts with 298 markers (Mir10b, Mir16-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component sarcoplasmic reticulum
Function GTPase activity, GTP binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (77)    Tissues (12)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
RT-PCR 4
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(56) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000026711 (Evidence)
Ensembl Gene ModelENSMUSG00000022519 (Evidence)
Entrez Gene106393 (Evidence)
UniGene35811
DFCITC1674030, TC1576864
DoTSDT.533510, DT.99843014
NIA Mouse Gene IndexU036739
Consensus CDS ProjectCCDS27918.1
International Mouse Knockout Project StatusSrl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026711 VEGA Gene Model | MGI Sequence Detail 61601 C57BL/6J ±  kb
transcript OTTMUST00000066087 VEGA | MGI Sequence Detail 5000 Not Applicable 
polypeptide OTTMUSP00000033050 VEGA | MGI Sequence Detail 910 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(381 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000015620 sarcalumenin
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory