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Prkaa1
Gene Detail
Symbol

Name
ID
Prkaa1
protein kinase, AMP-activated, alpha 1 catalytic subunit
MGI:2145955
Synonyms
AMPKalpha1, C130083N04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 15
1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:5143861-5181899 bp, + strand
From NCBI annotation of GRCm38

  38039 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49590  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKAA1
Protein SuperFamily: Snf1/AMPK-type protein kinase, catalytic subunit
Gene Tree: Prkaa1

Human
homologs
PRKAA1, protein kinase, AMP-activated, alpha 1 catalytic subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5562
neXtProt AC: NX_Q13131

Human Synonyms: AMPK, AMPKa1

Human Chr (Location): 5p12; chr5:40759379-40798195 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(25) Targeted(5)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased muscle cell glucose uptake. Mice homozygous for a different knock-out allele exhibit anemia, reticulocytosis, splenomegaly, increased erythrocyte turnover, and elevated plasma erythropoietin levels.
 
Interactions
Prkaa1 interacts with 372 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (26)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 26
cDNA source data(83)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkaa1    NEW 
Molecular
reagents
All nucleic(83) cDNA(83)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000050697 (Evidence)
Entrez Gene 105787 (Evidence)
UniGene 207004
DFCI TC1610417, TC1630021, TC1661343
DoTS DT.529728, DT.97399370, DT.97399368
NIA Mouse Gene Index U016022
EC 2.7.11.31, 2.7.11.27, 2.7.11.1, 2.7.11.26
Consensus CDS Project CCDS49574.1
International Mouse Phenotyping Consortium Status Prkaa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 105787 NCBI Gene Model | MGI Sequence Detail 38039 C57BL/6J ±  kb
transcript NM_001013367 RefSeq | MGI Sequence Detail 4655 C57BL/6 
polypeptide Q5EG47 UniProt | EBI | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(40) UniProt(3)
Polymorphisms
SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013218 5'-AMP-activated protein kinase catalytic subunit alpha-1
Graphical View of Protein Domain Structure
References
(Earliest) J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
(Latest) J:222038 Ameri K, et al., HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 12;
All references(185)
Other
accession IDs
MGI:2146014, MGI:2146120

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory