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Prkaa1
Gene Detail
 Symbol
Name
ID
Prkaa1
protein kinase, AMP-activated, alpha 1 catalytic subunit
MGI:2145955
Synonyms AMPKalpha1, C130083N04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 15
1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:5143861-5181899 bp, + strand
From NCBI annotation of GRCm38

  38039 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49590  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Snf1/AMPK-type protein kinase, catalytic subunit
Gene Tree: Prkaa1

Human
homologs
Human Homolog PRKAA1, protein kinase, AMP-activated, alpha 1 catalytic subunit
NCBI Gene ID 5562
neXtProt AC  NX_Q13131
Human Synonyms  AMPK, AMPKa1
Human Chr (Location)  5p12; chr5:40759379-40798195 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(25) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit decreased muscle cell glucose uptake. Mice homozygous for a different knock-out allele exhibit anemia, reticulocytosis, splenomegaly, increased erythrocyte turnover, and elevated plasma erythropoietin levels.
 
Interactions
Prkaa1 interacts with 373 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (78 annotations)
Process activation of MAPK activity, autophagy, ...
Component AMP-activated protein kinase complex, apical plasma membrane, ...
Function [acetyl-CoA carboxylase] kinase activity, AMP-activated protein kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (26)    Tissues (1)   
Theiler Stages: 20
Assay TypeResults
Western blot 26
cDNA source data(83)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) cDNA(83)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000050697 (Evidence)
Entrez Gene105787 (Evidence)
UniGene207004
DFCITC1610417, TC1630021, TC1661343
DoTSDT.529728, DT.97399368, DT.97399370
NIA Mouse Gene IndexU016022
EC2.7.11.1, 2.7.11.26, 2.7.11.27, 2.7.11.31
Consensus CDS ProjectCCDS49574.1
International Mouse Knockout Project StatusPrkaa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 105787 NCBI Gene Model | MGI Sequence Detail 38039 C57BL/6J ±  kb
transcript NM_001013367 RefSeq | MGI Sequence Detail 4655 C57BL/6 
polypeptide Q5EG47 UniProt | EBI | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(34) UniProt(3)
Polymorphisms SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013218 5'-AMP-activated protein kinase catalytic subunit alpha-1
Graphical View of Protein Domain Structure
References (Earliest) J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
(Latest) J:209505 Hasenour CM, et al., 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo. J Biol Chem. 2014 Feb 28;289(9):5950-9
All references(172)
Other
accession IDs
MGI:2146014, MGI:2146120

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory