About   Help   FAQ
Slf1 Gene Detail
Summary
  • Symbol
    Slf1
  • Name
    SMC5-SMC6 complex localization factor 1
  • Synonyms
    2700017A04Rik, Ankrd32, Brctd1, Brctx, C730024G01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145448
    NCBI Gene: 105377
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:77043088-77135473 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.98 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    771 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145448
protein coding gene Chr13:77043088-77135509 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020780
protein coding gene Chr13:77605890-77699311 (-)
A/J MGP_AJ_G0020736
protein coding gene Chr13:74961157-75059553 (-)
AKR/J MGP_AKRJ_G0020709
protein coding gene Chr13:77228281-77320205 (-)
BALB/cJ MGP_BALBcJ_G0020732
protein coding gene Chr13:75448805-75558014 (-)
C3H/HeJ MGP_C3HHeJ_G0020526
protein coding gene Chr13:76945206-77032863 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021169
protein coding gene Chr13:80197413-80296542 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018737
protein coding gene Chr13:71701640-71784327 (-)
CAST/EiJ MGP_CASTEiJ_G0020044
protein coding gene Chr13:76028454-76126253 (-)
CBA/J MGP_CBAJ_G0020485
protein coding gene Chr13:83237606-83340356 (-)
DBA/2J MGP_DBA2J_G0020610
protein coding gene Chr13:74663014-74760201 (-)
FVB/NJ MGP_FVBNJ_G0020590
protein coding gene Chr13:73735615-73827793 (-)
LP/J MGP_LPJ_G0020683
protein coding gene Chr13:77869103-77966183 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020619
protein coding gene Chr13:81677704-81787420 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021209
protein coding gene Chr13:76533641-76627297 (-)
PWK/PhJ MGP_PWKPhJ_G0019797
protein coding gene Chr13:73572676-73668779 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019620
protein coding gene Chr13:72933124-73019941 (-)
WSB/EiJ MGP_WSBEiJ_G0020101
protein coding gene Chr13:77061828-77157187 (-)



Homology
more
  • Human Ortholog
    SLF1, SMC5-SMC6 complex localization factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLF1, SMC5-SMC6 complex localization factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANKRD32, BRCTD1, BRCTx
  • Links
    NCBI Gene ID: 84250
    neXtProt AC: NX_Q9BQI6
    UniProt: Q9BQI6

  • Chr Location
    5q15; chr5:94613477-94697733 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 13000
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Homozygous null mice are developmentally normal and fertile with no pathological abnormalities or defects in T-cell development and genomic stability. Mutant MEFs grow at a normal rate and are not more sensitive to DNA-damaging agents while thymocytes donot show any major cell cycle defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021597 Ensembl Gene Model | MGI Sequence Detail 92386 C57BL/6J ±  kb
transcript ENSMUST00000151524 Ensembl | MGI Sequence Detail 3747 Not Applicable  
polypeptide ENSMUSP00000118312 Ensembl | MGI Sequence Detail 1054 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919823
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:224731 Liu T, et al., RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst). 2012 Feb 1;11(2):131-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory