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Slf1 Gene Detail
Summary
  • Symbol
    Slf1
  • Name
    SMC5-SMC6 complex localization factor 1
  • Synonyms
    2700017A04Rik, Ankrd32, Brctd1, Brctx, C730024G01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145448
    NCBI Gene: 105377
Location & Maps
more
  • Sequence Map
    Chr13:77043088-77135473 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92386 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.98 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLF1, SMC5-SMC6 complex localization factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLF1, SMC5-SMC6 complex localization factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANKRD32, BRCTD1, BRCTx
  • Links
    NCBI Gene ID: 84250
    neXtProt AC: NX_Q9BQI6

  • Chr Location
    5q15; chr5:94615858-94714918 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 13000
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Targeted
    2
  • Genomic Mutations
    1 involving Slf1
  • Incidental Mutations
Homozygous null mice are developmentally normal and fertile with no pathological abnormalities or defects in T-cell development and genomic stability. Mutant MEFs grow at a normal rate and are not more sensitive to DNA-damaging agents while thymocytes donot show any major cell cycle defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033900 VEGA Gene Model | MGI Sequence Detail 92386 C57BL/6J ±  kb
transcript OTTMUST00000085507 VEGA | MGI Sequence Detail 3747 Not Applicable  
polypeptide OTTMUSP00000046193 VEGA | MGI Sequence Detail 1054 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    771 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919823
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224731 Liu T, et al., RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst). 2012 Feb 1;11(2):131-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory