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Wdpcp
Gene Detail
 Symbol
Name
ID
Wdpcp
WD repeat containing planar cell polarity effector
MGI:2144467
Synonyms AV249152, homoloc-13
Feature Type protein coding gene
Genetic Map
Chromosome 11
13.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:21572235-21898989 bp, + strand
From VEGA annotation of GRCm38

  326755 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Wdpcp

Human
homologs
Human Homolog WDPCP, WD repeat containing planar cell polarity effector
NCBI Gene ID 51057
neXtProt AC  NX_O95876
Human Synonyms  BBS15, C2orf86, FRITZ, FRTZ
Human Chr (Location)  2p15; chr2:63121383-63588733 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human WDPCP
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display ciliogenesis defects, anophthalmia, cysts in multiple tissues, central polydactyly, duplex kidney, and septation defects in the outflow tract and cloaca.
 
Interactions
Wdpcp interacts with 92 markers (Mir7-2, Mir7b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process auditory receptor cell morphogenesis, camera-type eye development, ...
Component axonemal basal plate, cell projection, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (16)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 98
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005251 (Evidence)
Ensembl Gene ModelENSMUSG00000020319 (Evidence)
Entrez Gene216560 (Evidence)
UniGene138090
DFCITC1583072, TC1589803, TC1621701, TC1694227
DoTSDT.101190082, DT.101271958, DT.60104172, DT.91305972, DT.91332564, DT.91592775
NIA Mouse Gene IndexU012364
Consensus CDS ProjectCCDS24467.1
International Mouse Knockout Project StatusWdpcp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005251 VEGA Gene Model | MGI Sequence Detail 326755 C57BL/6J ±  kb
transcript OTTMUST00000011710 VEGA | MGI Sequence Detail 2792 Not Applicable 
polypeptide OTTMUSP00000005428 VEGA | MGI Sequence Detail 722 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(28) UniProt(4)
Polymorphisms SNPs within 2kb(1021 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1031)
Protein-related
information
ResourceIDDescription
InterPro IPR024511 Protein of unknown function DUF3312
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000030333 WD repeat-containing and planar cell polarity effector protein fritz homolog
References (Earliest) J:83520 Fuchs S, et al., Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genet. 2002 Aug 13;3(1):14
(Latest) J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory