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Wdpcp
Gene Detail
Symbol

Name
ID
Wdpcp
WD repeat containing planar cell polarity effector
MGI:2144467
Synonyms
AV249152, homoloc-13
Feature Type
protein coding gene
Genetic Map
Chromosome 11
13.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:21572235-21898989 bp, + strand
From VEGA annotation of GRCm38

  326755 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WDPCP
Gene Tree: Wdpcp

Human
homologs
WDPCP, WD repeat containing planar cell polarity effector
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51057
neXtProt AC: NX_O95876

Human Synonyms: BBS15, C2orf86, CHDTHP, FRITZ, FRTZ

Human Chr (Location): 2p15; chr2:63120762-63840825 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human WDPCP

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display ciliogenesis defects, anophthalmia, cysts in multiple tissues, central polydactyly, duplex kidney, and septation defects in the outflow tract and cloaca.
 
Interactions
Wdpcp interacts with 91 markers (Mir7-2, Mir7b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process auditory receptor cell morphogenesis, camera-type eye development, ...
Component axonemal basal plate, cell projection, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (16)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wdpcp    NEW 
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005251 (Evidence)
Ensembl Gene Model ENSMUSG00000020319 (Evidence)
Entrez Gene 216560 (Evidence)
UniGene 138090
DFCI TC1583072, TC1694227, TC1621701, TC1589803
DoTS DT.91592775, DT.101271958, DT.91332564, DT.60104172, DT.101190082, DT.91305972
NIA Mouse Gene Index U012364
Consensus CDS Project CCDS24467.1
International Mouse Phenotyping Consortium Status Wdpcp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005251 VEGA Gene Model | MGI Sequence Detail 326755 C57BL/6J ±  kb
transcript OTTMUST00000011710 VEGA | MGI Sequence Detail 2792 Not Applicable 
polypeptide OTTMUSP00000005428 VEGA | MGI Sequence Detail 722 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(22) UniProt(4)
Polymorphisms
SNPs within 2kb(1021 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1031)
Protein-related
information
ResourceIDDescription
InterPro IPR024511 Protein of unknown function DUF3312
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000030333 WD repeat-containing and planar cell polarity effector protein fritz homolog
References
(Earliest) J:83520 Fuchs S, et al., Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genet. 2002 Aug 13;3(1):14
(Latest) J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory