About   Help   FAQ
Wdpcp Gene Detail
Summary
  • Symbol
    Wdpcp
  • Name
    WD repeat containing planar cell polarity effector
  • Synonyms
    AV249152, homoloc-13
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144467
    NCBI Gene: 216560
Location & Maps
more
  • Sequence Map
    Chr11:21572235-21898989 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      326755 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    WDPCP, WD repeat containing planar cell polarity effector
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDPCP, WD repeat containing planar cell polarity effector
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BBS15, C2orf86, CHDTHP, FRITZ, FRTZ
  • Links
    NCBI Gene ID: 51057
    neXtProt AC: NX_O95876

  • Chr Location
    2p15; chr2:63120762-63840825 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9299
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: WDPCP
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human WDPCP associations

Human Disease Mouse Models
       Bardet-Biedl Syndrome 15; BBS15   OMIM: 615992
Congenital Heart Defects, Hamartomas of Tongue, and Polysyndactyly;   OMIM: 217085
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Wdpcp
  • Incidental Mutations
Mice homozygous for a null mutation display ciliogenesis defects, anophthalmia, cysts in multiple tissues, central polydactyly, duplex kidney, and septation defects in the outflow tract and cloaca.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005251 VEGA Gene Model | MGI Sequence Detail 326755 C57BL/6J ±  kb
transcript OTTMUST00000011710 VEGA | MGI Sequence Detail 2792 Not Applicable  
polypeptide OTTMUSP00000005428 VEGA | MGI Sequence Detail 722 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    999 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030333 WD repeat-containing and planar cell polarity effector protein fritz homolog
  • InterPro Domains
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
    IPR024511 WD repeat-containing and planar cell polarity effector protein Fritz
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:83520 Fuchs S, et al., Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genet. 2002 Aug 13;3(1):14
  • Latest
    J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory