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Wdpcp Gene Detail
Summary
  • Symbol
    Wdpcp
  • Name
    WD repeat containing planar cell polarity effector
  • Synonyms
    AV249152, homoloc-13
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144467
    NCBI Gene: 216560
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:21572235-21898989 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 13.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    999 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144467
protein coding gene Chr11:21571869-21898989 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018074
protein coding gene Chr11:19205584-19539570 (+)
A/J MGP_AJ_G0018047
protein coding gene Chr11:18498163-18815954 (+)
AKR/J MGP_AKRJ_G0018011
protein coding gene Chr11:19165289-19503736 (+)
BALB/cJ MGP_BALBcJ_G0018015
protein coding gene Chr11:18633196-18955445 (+)
C3H/HeJ MGP_C3HHeJ_G0017829
protein coding gene Chr11:19031432-19375120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018467
protein coding gene Chr11:20048225-20402877 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016125
protein coding gene Chr11:17444434-17778564 (+)
CAST/EiJ MGP_CASTEiJ_G0017390
protein coding gene Chr11:19040422-19400572 (+)
CBA/J MGP_CBAJ_G0017803
protein coding gene Chr11:20907718-21284612 (+)
DBA/2J MGP_DBA2J_G0017913
protein coding gene Chr11:18445823-18770521 (+)
FVB/NJ MGP_FVBNJ_G0017905
protein coding gene Chr11:18209303-18536076 (+)
LP/J MGP_LPJ_G0017984
protein coding gene Chr11:19362094-19702874 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017931
protein coding gene Chr11:21341263-21732451 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018508
protein coding gene Chr11:19260817-19598827 (+)
PWK/PhJ MGP_PWKPhJ_G0017171
protein coding gene Chr11:18472943-18796084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016968
protein coding gene Chr11:18992335-19347767 (+)
WSB/EiJ MGP_WSBEiJ_G0017444
protein coding gene Chr11:18890945-19228553 (+)



Homology
more
  • Human Ortholog
    WDPCP, WD repeat containing planar cell polarity effector
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDPCP, WD repeat containing planar cell polarity effector
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BBS15, C2orf86, CHDTHP, CPLANE5, FRITZ, FRTZ
  • Links
    NCBI Gene ID: 51057
    neXtProt AC: NX_O95876
    UniProt: O95876

  • Chr Location
    2p15; chr2:63120755-63840825 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9299
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WDPCP
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human WDPCP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display ciliogenesis defects, anophthalmia, cysts in multiple tissues, central polydactyly, duplex kidney, and septation defects in the outflow tract and cloaca.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020319 Ensembl Gene Model | MGI Sequence Detail 326755 C57BL/6J ±  kb
    transcript ENSMUST00000020568 Ensembl | MGI Sequence Detail 2792 Not Applicable  
    polypeptide ENSMUSP00000020568 Ensembl | MGI Sequence Detail 722 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000030333 WD repeat-containing and planar cell polarity effector protein fritz homolog
    • InterPro Domains
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
      IPR024511 WD repeat-containing and planar cell polarity effector protein Fritz
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:259048 Liu X, et al., Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling. Sci Signal. 2018 Feb 27;11(519)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory