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Traf3ip2 Gene Detail
Summary
  • Symbol
    Traf3ip2
  • Name
    TRAF3 interacting protein 2
  • Synonyms
    Act1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143599
    NCBI Gene: 103213
  • Gene Overview
    MyGene.info: TRAF3IP2
Location & Maps
more
  • Sequence Map
    Chr10:39612934-39655307 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42374 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TRAF3IP2, TRAF3 interacting protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TRAF3IP2, TRAF3 interacting protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13
  • Links
    NCBI Gene ID: 10758
    neXtProt AC: NX_O43734

  • Chr Location
    6q21; chr6:111555378-111606874 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Traf3ip2 mouse models; 2 with human TRAF3IP2 associations

Human Disease Mouse Models
       Dermatitis, Atopic   OMIM: 603165 View 5 models
Sjogren Syndrome   OMIM: 270150 View 1 model
Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 2 models
       Candidiasis, Familial, 8; CANDF8   OMIM: 615527
Psoriasis 13, Susceptibility To; PSORS13   OMIM: 614070
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    58 phenotypes from 5 alleles in 11 genetic backgrounds
    45 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Traf3ip2
  • Incidental Mutations
Mice homozygous for one null allele exhibit splenomegaly, lymphadenopathy, increased number of B cells, defective IL-17 signaling, and increased immunoglobulin levels (including auto-antibodies) whereas mice homozygous for another null allele lack these features except the defect in IL-17 signaling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031773 VEGA Gene Model | MGI Sequence Detail 42374 C57BL/6J ±  kb
transcript OTTMUST00000078716 VEGA | MGI Sequence Detail 2867 Not Applicable  
polypeptide OTTMUSP00000041902 VEGA | MGI Sequence Detail 555 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    188 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR013568 SEFIR domain
Molecular
Reagents
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  • All nucleic 49
    cDNA 49

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Diseases 5
    Gene Ontology 6
    Phenotypes 37
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:229778 Reynolds JM, et al., Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation. Immunity. 2015 Apr 21;42(4):692-703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory