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Traf3ip2
Gene Detail
Symbol

Name
ID
Traf3ip2
TRAF3 interacting protein 2
MGI:2143599
Synonyms
Act1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
20.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:39612934-39655307 bp, + strand
From VEGA annotation of GRCm38

  42374 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: TRAF3IP2
Gene Tree: Traf3ip2

Human
homologs
TRAF3IP2, TRAF3 interacting protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10758
neXtProt AC: NX_O43734

Human Synonyms: ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13

Human Chr (Location): 6q21; chr6:111555378-111606874 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TRAF3IP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(22) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele exhibit splenomegaly, lymphadenopathy, increased number of B cells, defective IL-17 signaling, and increased immunoglobulin levels (including auto-antibodies) whereas mice homozygous for another null allele lack these features except the defect in IL-17 signaling.
 
Human Diseases Modeled in Mice Using Traf3ip2 (3)    Mutations Annotated to Human Diseases (3)   
Interactions
Traf3ip2 interacts with 114 markers (Mir18, Mir19a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process B cell apoptotic process, humoral immune response, ...
Component cell
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase traf3ip3 ; ZFIN traf3ip2a    NEW 
Molecular
reagents
All nucleic(49) cDNA(49)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031773 (Evidence)
Ensembl Gene Model ENSMUSG00000019842 (Evidence)
Entrez Gene 103213 (Evidence)
UniGene 436686
DFCI TC1577936
DoTS DT.491139
NIA Mouse Gene Index U043060
Consensus CDS Project CCDS23789.1
International Mouse Phenotyping Consortium Status Traf3ip2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031773 VEGA Gene Model | MGI Sequence Detail 42374 C57BL/6J ±  kb
transcript OTTMUST00000078716 VEGA | MGI Sequence Detail 2867 Not Applicable 
polypeptide OTTMUSP00000041902 VEGA | MGI Sequence Detail 555 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013568 SEFIR
Protein Ontology PR:000016602 adapter protein CIKS
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:213917 Ha HL, et al., IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3422-31
All references(57)
Disease annotation references (3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory