A4gnt MGI Mouse Gene Detail - MGI:2143261 - alpha-1,4-N-acetylglucosaminyltransferase

Symbol

A4gnt
Name

alpha-1,4-N-acetylglucosaminyltransferase
Synonyms

alpha4GnT, LOC333424

Feature Type

protein coding gene
IDs

MGI:2143261
NCBI Gene: 333424
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:99494555-99504420 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 51.91 cM
Mapping Data

2 experiments

SNPs within 2kb

116 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143261	protein coding gene	Chr9:99473233-99504420 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035172	protein coding gene	Chr9:100988511-100999549 (+)
A/J	MGP_AJ_G0035153	protein coding gene	Chr9:97428359-97439078 (+)
AKR/J	MGP_AKRJ_G0035085	protein coding gene	Chr9:99796925-99806390 (+)
BALB/cJ	MGP_BALBcJ_G0035146	protein coding gene	Chr9:97114794-97125160 (+)
C3H/HeJ	MGP_C3HHeJ_G0034856	protein coding gene	Chr9:100216027-100227355 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035666	protein coding gene	Chr9:103880380-103892744 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032565	protein coding gene	Chr9:95153034-95160605 (+)
CAST/EiJ	MGP_CASTEiJ_G0034167	protein coding gene	Chr9:100017983-100031847 (+)
CBA/J	MGP_CBAJ_G0034824	protein coding gene	Chr9:107434821-107450024 (+)
DBA/2J	MGP_DBA2J_G0034986	protein coding gene	Chr9:96939966-96949423 (+)
FVB/NJ	MGP_FVBNJ_G0034934	protein coding gene	Chr9:95756375-95765962 (+)
LP/J	MGP_LPJ_G0035062	protein coding gene	Chr9:101239040-101248796 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034973	protein coding gene	Chr9:109349083-109361241 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035688	protein coding gene	Chr9:100050283-100059712 (+)
PWK/PhJ	MGP_PWKPhJ_G0033874	protein coding gene	Chr9:97153294-97163514 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033709	protein coding gene	Chr9:100105980-100116065 (+)
WSB/EiJ	MGP_WSBEiJ_G0034287	protein coding gene	Chr9:99912803-99922235 (+)

Human Ortholog

A4GNT, alpha-1,4-N-acetylglucosaminyltransferase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

A4GNT, alpha-1,4-N-acetylglucosaminyltransferase
Synonyms

alpha4GnT
Links

HGNC:17968

NCBI Gene ID: 51146

neXtProt AC: NX_Q9UNA3

UniProt: Q9UNA3
Chr Location

3q22.3; chr3:138123713-138133302 (-) GRCh38

MGI Vertebrate Homology

A4gnt stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: A4GNT
Gene Tree

A4gnt

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
3 images
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Targeted

2
Genomic Mutations

1 involving A4gnt
Incidental Mutations

APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit gastric adenocarcinoma with increased cell proliferation, angiogenesis, inflammation and gastric mucosal thickness.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase a4gnt

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All Sequences

33
RefSeq

6
UniProt

1
CCDS

CCDS40740.1

Ensembl

ENSMUSG00000037953 (Evidence)
NCBI Gene

333424

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037953	Ensembl Gene Model \| MGI Sequence Detail	9866	C57BL/6J	± kb
transcript	ENSMUST00000042553	Ensembl \| MGI Sequence Detail	2757	Not Applicable
polypeptide	ENSMUSP00000045629	Ensembl \| MGI Sequence Detail	341	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003517 alpha-1,4-N-acetylglucosaminyltransferase

(term hierarchy)
EC

2.4.1.-
InterPro Domains

IPR007652 Alpha 1,4-glycosyltransferase domain

IPR007577 Glycosyltransferase, DXD sugar-binding motif

IPR029044 Nucleotide-diphospho-sugar transferases

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All nucleic 7

Genomic 2

cDNA 5

Microarray probesets 2

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MGI:2685644

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 4
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:308628 Iida M, et al., Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice. Sci Rep. 2021 Jul 1;11(1):13640

TSS for A4gnt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86685	Chr9:99494521-99494582 (+)	-3 bp
Tssr86686	Chr9:99494598-99494610 (+)	49 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23