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A4gnt Gene Detail
Summary
  • Symbol
    A4gnt
  • Name
    alpha-1,4-N-acetylglucosaminyltransferase
  • Synonyms
    alpha4GnT, LOC333424
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143261
    NCBI Gene: 333424
Location & Maps
more
  • Sequence Map
    Chr9:99612502-99622367 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9866 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.91 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    A4GNT, alpha-1,4-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    28
  • Human Ortholog
    A4GNT, alpha-1,4-N-acetylglucosaminyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    alpha4GnT
  • Links
    NCBI Gene ID: 51146
    neXtProt AC: NX_Q9UNA3

  • Chr Location
    3q22.3; chr3:138123718-138132387 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 images
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving A4gnt
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit gastric adenocarcinoma with increased cell proliferation, angiogenesis, inflammation and gastric mucosal thickness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048239 VEGA Gene Model | MGI Sequence Detail 9866 C57BL/6J ±  kb
transcript OTTMUST00000123834 VEGA | MGI Sequence Detail 2757 Not Applicable  
polypeptide OTTMUSP00000067519 VEGA | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    248 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007652 Alpha 1,4-glycosyltransferase domain
    IPR007577 Glycosyltransferase, DXD sugar-binding motif
    IPR029044 Nucleotide-diphospho-sugar transferases
Molecular
Reagents
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  • All nucleic 6
    Genomic 1
    cDNA 5

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685644
References
more
  • Summaries
    All 20
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:184485 Karasawa F, et al., Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest. 2012 Mar 1;122(3):923-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory