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A4gnt
Gene Detail
 Symbol
Name
ID
A4gnt
alpha-1,4-N-acetylglucosaminyltransferase
MGI:2143261
Synonyms alpha4GnT, LOC333424
Feature Type protein coding gene
Genetic Map
Chromosome 9
51.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:99612502-99622367 bp, + strand
From VEGA annotation of GRCm38

  9866 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:87446  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 20 western clawed frog

Gene Tree: A4gnt

Human
homologs
Human Homolog A4GNT, alpha-1,4-N-acetylglucosaminyltransferase
NCBI Gene ID 51146
neXtProt AC  NX_Q9UNA3
Human Synonyms  alpha4GnT
Human Chr (Location)  3p14.3; chr3:138123718-138132387 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit gastric adenocarcinoma with increased cell proliferation, angiogenesis, inflammation and gastric mucosal thickness.
 
Phenotype Images(3)
Interactions
A4gnt interacts with 174 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process glycoprotein biosynthetic process, negative regulation of epithelial cell proliferation, ...
Component cellular_component
Function acetylglucosaminyltransferase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000048239 (Evidence)
Ensembl Gene ModelENSMUSG00000037953 (Evidence)
Entrez Gene333424 (Evidence)
UniGene297753
DoTSDT.55175215
NIA Mouse Gene IndexU111114
Consensus CDS ProjectCCDS40740.1
International Mouse Knockout Project StatusA4gnt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048239 VEGA Gene Model | MGI Sequence Detail 9866 C57BL/6J ±  kb
transcript OTTMUST00000123834 VEGA | MGI Sequence Detail 2757 Not Applicable 
polypeptide OTTMUSP00000067519 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007652 Alpha 1,4-glycosyltransferase domain
InterPro IPR007577 Glycosyltransferase, DXD sugar-binding motif
Protein Ontology PR:000003517 alpha-1,4-N-acetylglucosaminyltransferase
References (Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:184485 Karasawa F, et al., Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest. 2012 Mar 1;122(3):923-34
All references(25)
Other
accession IDs
MGI:2685644

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory